ABSTRACT
Object:
To prepare a national guideline for Otorhinolaryngologist who treat allergic rhinitis patients.
Methods:
The study was conducted by three authors, namely the writing support team. The support team made the study plan, determined the writing instructions, chose the subgroups including the advisory committee, the advisors for authors and the authors. A workshop was organized at the very beginning to explain the details of the study to the team. Advisors took the chance to meet their coworkers in their subgroups and determined the main headings and subheadings of the guideline, together with the authors. After key words were determined by the authors, literature search was done in various databases. The authors keep in touch with the advisors and the advisors with the advisory committee and the support group at every stage of the study. National and International published articles as well as the abstracts of unpublished studies, imperatively presented in National Congresses, were included in this guideline. Only Guideline and meta-analyses published in last seven years (2013-2017) and randomized controlled studies published in last two years (2015-2017) were included. After all work was completed by the subgroups, support team brought all work together and edited the article.
Results:
A detailed guideline about all aspects of allergic rhinitis was created.
Conclusion:
The authors believe that this guideline will enable a compact and up-to-date information on allergic rhinitis to healthcare professionals. This guideline is the first in the field of Otolaryngology in Turkey. It should be updated at regular intervals.
Keywords:
Allergic rhinitis, guideline, rhinitis
References
1
Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001;108 (5 Suppl): S147- S334.
2
Pawankar R, Hayashi M, Yamanishi S, Igarashi T. The paradigm of cytokine networks in allergic airway inflammation. Curr Opin AllergyClin Immunol 2015; 15: 41-48.
3
Baroody FM, Naclerio RM. Allergy and Immunology of the Upper Airway. In. Valerie J. Lund, Editor 6th edition Cummings Otolaryngology. Philadelphia: Mosby/Elsevier; 2015.p. 593-625.
4
Akdis M. The cellular orchestra in skin allergy; are differences to lung and nose relevant? Curr Opin AllergyClin Immunol 2010; 10: 443-451.
5
Akdis CA, Akdis M. Mechanisms of allergen-specific immunotherapy. J AllergyClin Immunol 2011; 127: 18-27.
6
Akdis M, Blaser K, Akdis CA. T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases. J Allergy Clin Immunol 2005; 116: 961-8.
7
Chatila TA, Blaeser F, Ho N, Lederman HM, Voulgaropoulos C, Helms C, et al. Encoding a fork head-related protein, is mutated in X-linkedautoimmunity-allergic disregulation syndrome. J Clin Invest 2000; 106: R75-81.
8
Anderson AE, Mackerness KJ, Aizen M, Carr VA, Nguyen D, Du Pre F, et al. Seasonal changes in suppressive capacity of CD4+ CD25+ T cells from patients with hay fever are allergen-specific and may result in part from expansion of effector T cells among the CD25+ population. Clin Exp Allergy 2009; 39: 1693-9.
9
Han D, Wang C, Lou W, Gu Y, Wang Y, Zhang L. Allergen-specific IL-10-secretingtype I T regulatory cells, but not CD4 (+) CD25 (+) Foxp3 (+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis. Clin Immunol 2010; 136: 292-301.
10
De Smet K, Contreras R. Human antimicrobial peptides: defensins, cathelicidins and histatins. Biotechnol Lett 2005 ; 27: 1337-47.
11
Siracusa MC, Kim BS, Spergel JM, Artis D. Basophils and allergic inflammation. J Allergy Clin Immunol 2013; 132: 789-801.
12
Falcone FH, Knol EF, Gibbs BF. The role of basophils in the pathogenesis of allergic disease. Clin Exp Allergy 2011; 41: 939-47.
13
Doherty TA. At the Bench: Understanding group 2 innate lymphoid cells in disease. J LeukocBiol 2014; 97: 455-67.
14
Mesdaghi M, Vodjgani M, Salehi E, Hadjati J, Sarrafnejad A, BidadK, et al. Natural killer cells in allergic rhinitis patients and non atopic controls. Int Arch Allergy Immunol 2010; 153: 234-8.
15
Bentley AM, Jacobson MR, Cumberworth V, Barkans JR, MoqbelR, Schwartz LB, et al. Immunohistology of the nasal mucosa in seasonal allergic rhinitis: increases inactivated eosinophils and epithelial mast cells. J Allergy Clin Immunol 1992; 89: 877-83.
16
Merad M, Sathe P, Helft J, Miller J, Mortha A. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol 2013; 31: 563-604.
17
Reinartz SM, van Tongeren J, van Egmond D, de Groot EJJ, Fokkens WJ, van Drunen CM. Dendritic cells in nasal mucosa of subjects with different allergic sensitizations. J Allergy Clin Immunol 2011; 128:887-90.
18
Blander JM, Medzhitov R. Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature 2006; 440: 808-12.
19
Akdis CA, Akdis M. Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs. J Clin Invest 2014; 124: 4678-80.
20
Salib RJ, Kumar S, Wilson SJ, Howarth PH. Nasal mucosal immunoexpression of the mast cell chemoattractants TGF-beta, eotaxin and stem cell factor and their receptors in allergic rhinitis. J Allergy Clin Immunol 2004; 114: 799-806.
21
Cazzoletti L, Ferrari M, Olivieri M, Verlato G, Antonicelli L, Bono R, et al. The gender, age and risk factor distribution differs in self-reported allergic andnon-allergic rhinitis: a cross-sectional population-based study. Allergy Asthma Clin Immunol 2015; 4; 11-36.
22
Akdis M, Burgler S, Crameri R, Eiwegger T, Fujita H, Gomez E et al. Interleukins, from 1 to 37, and interferon- gamma: receptors, functions and roles in diseases. J Allergy Clin Immunol 2011; 127: 701-21.
23
Rondón C, Campo P, Togias A, Fokkens WJ, Durham SR, Powe DG, et al. Local allergic rhinitis: concept, pathophysiology, and management. J Allergy Clin Immunol 2012; 129: 1460-7.
24
Simon HU, Yousefi S, Schranz C, Schapowal A, Bachert C, Blaser K. Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia. J Immunol 1997;158:3902-8.
25
Shahab R, Phillips DE, Jones AS. Prostaglandins, leukotrienes and perennial rhinitis. J Laryngol Otol 2004; 118: 500-7.
26
Kojima T, Go M, Takano K, Kurose M, Ohkuni T, Koizumi J, et al. Regulation of tight junctions in upper airway epithelium. Biomed Res Int 2013; 2013: 947072.
27
Aryan Z, Rezaei N, Camargo CA Jr. Vitamin D status, aeroallergen sensitization, and allergic rhinitis: A systematic review and meta-analysis. Int Rev Immunol 2017; 36: 41-53.
28
Baraniuk JN. Rise of the sensors: nociception and pruritus. Curr Allergy Asthma Rep 2012; 12: 104-14.
29
Gerth van Wijk RG, de Graaf-in ‘t Veld C, Garrelds IM. Nasal hyperreactivity. Rhinology 1999; 37: 50-5.
30
Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, et al. Joint Task Force on Practice; American Academy of Allergy; Asthma & Immunology; American College of Allergy; Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 2008; 122 (2 Suppl): S1-84.
31
Tatar EC. Alerjik rinit: Tanım ve sınıflandırma. Turkiye Klinikleri E.N.T-special topics 2015; 8: 1-3.
32
Rondón C, Doña I, López S, Campo P, Romero JJ, Torres MJ, et al. Seasonal idiopathic rhinitis with local inflammatory response and specific IgE in absence of systemic response. Allergy 2008; 63: 1352-8.
33
Rondón C, Romero JJ, López S, Antúnez C, Martín-Casañez E, Torres MJ, et al. Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis. J Allergy Clin Immunol 2007; 119: 899-905.
34
Wedbäck A, Enbom H, Eriksson NE, Movérare R, Malcus I. Seasonal non-allergic rhinitis (SNAR) a new disease entity? A clinical and immunological comparison between SNAR, seasonal allergic rhinitis and persistent non-allergic rhinitis. Rhinology 2005; 43: 86-92.
35
Rondón C, Fernández J, López S, Campo P, Doña I, Torres MJ, et al. Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis. J Allergy Clin Immunol 2009; 124: 1005-11.e1.
36
Rondón C, Campo P, Herrera R, Blanca-Lopez N, Melendez L, Canto G, et al. Nasal allergen provocation test with multiple aeroallergens detects polysensitization in local allergic rhinitis. J Allergy Clin Immunol 2011 ; 128: 1192-7.
37
Schappert SM, Rechtsteiner EA. Ambulatory medical care utilization estimates for 2006. Natl Health Stat Report 2008; 6: 1-29.
38
Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA²LEN and AllerGen). Allergy 2008; 63: 86: 8-160.
39
Mims JW. Epidemiology of allergic rhinitis. Int Forum Allergy Rhinol 2014; 4 Suppl 2: S18-20.
40
Salo PM, Calatroni A, Gergen PJ, Hoppin JA, Sever ML, Jaramillo R, et al. Allergy related outcomes in relation to serum IgE: results from the National Health and Nutrition Examination Survey 2005-2006. J Allergy Clin Immunol 2011; 127: 1226-35.
41
Cingi C, Topuz B, Songu M, Kara CO, Ural A, Yaz A, et al. Prevalence of allergic rhinitis among the adult population in Turkey. Acta Oto-Laryngologica 2010; 130: 600-6.
42
Aktaş A, Rahman S, Elbi H, Özyurt BC. Üniversite öğrencilerinde alerjik rinit sıklığı ve ilişkili faktörler. CBU-SBED 2015; 2: 36-40.
43
Çobanoğlu HB, Işık AÜ, Topbaş M, Ural A. Prevalence of allergic rhinitis in children in the Trabzon province of the black sea region of Turkey. Turk Arch Otorhinolaryngol 2016; 54: 21-8.
44
Kaiser R, Schindler C, Kunzli N, Ackermann-Liebrich U, Heeb D, Medici TC, et al. Use of transition probabilities to estimate the effect of smoking on the duration of episodes of respiratory symptoms in diary data: the Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA). Am J Epidemiol 1998; 148: 600-8.
45
Okubo K, Kurono Y, Ichimura K, Enomoto T, Okamoto Y, Kawauchi H, et al. Japanese Society of Allergology. Japanese Guideline for allergic rhinitis 2017. Allergol Int 2017; 66 : 205-19.
46
Goronfolah L. Aeroallergens, atopy and allergic rhinitis in the Middle East. Eur Ann Allergy Clin Immunol 2016; 48: 5-21.
47
Kim DH, Park YS, Jang HJ, Kim JH, Lim DH. Prevalence and allergen of allergic rhinitis in Korean children. Am J Rhinol Allergy 2016; 30: 72-8.
48
Duksal F, Akcay A, Becerir T, Ergin A, Becerir C, Guler N. Rising trend of allergic rhinitis prevalence among Turkish schoolchildren. Int J Pediatr Otorhinolaryngol 2013; 77: 1434-9.
49
Tamay Z, Akcay A, Ergin A, Güler N. Dietary habits and prevalence of allergic rhinitis in 6 to 7-year-old schoolchildren in Turkey. Allergol Int 2014; 63: 553-62.
50
Talay F, Kurt B, Tug T, Kurt OK, Goksugur N, Yasar Z. The prevalence of asthma and allergic diseases among adults 30-49 years of age in Bolu, Western Black Sea Region of Turkey. Clin Ter 2014; 165: e59-63.
51
Tamay Z, Akçay A, Ergin A, Güler N. Prevalence of allergic rhinitis and risk factors in 6 to 7 yearold children in İstanbul, Turkey. Turk J Pediatr 2014; 56: 31-40.
52
Yoo B, Park Y, Park K, Kim H. A 9-year Trend in the Prevalence of Allergic Disease Based on National Health Insurance Data. J Prev Med Public Health 2015; 48: 301-9.
53
Pinart M, Keller T, Reich A, Fröhlich M, Cabieses B, Hohmann C, et al. Sex-Related Allergic Rhinitis Prevalence Switch from Childhood to Adulthood: A Systematic Review and Meta-Analysis. Int Arch Allergy Immunol 2017; 172: 224-35.
54
Zheng M, Wang X, Bo M, Wang K, Zhao Y, He F, et al. Prevalence of allergic rhinitis among adults in urban and rural areas of china: a population-based cross-sectional survey. Allergy Asthma Immunol Res 2015; 7: 148-57.
55
Song WJ, Sohn KH, Kang MG, Park HK, Kim MY, Kim SH, et al. Urban-rural differences in the prevalence of allergen sensitization and self-reported rhinitis in the elderly population. Ann Allergy Asthma Immunol 2015; 114: 455-61.
56
Krzych-Fałta E, Furmańczyk K, Piekarska B, Tomaszewska A, Sybilski A, Samoliński BK. Allergies in urban versus countryside settings in Poland as part of the Epidemiology of the Allergic Diseases in Poland (ECAP) study - challengethe early differential diagnosis. Postepy Dermatol Alergol 2016; 33: 359-68.
57
Wronka I, Kliś K, Jarzebak K. Association of Allergic Rhinitis in Female University Students with Socio-economic Factors and Markers of Estrogens Levels. Adv Exp Med Biol 2016; 884: 53-9.
58
Jung CG, Lee JH, Ban GY, Park HS, Shin YS. Prevalence and Clinical Characteristics of Local Allergic Rhinitis to House Dust Mites. Yonsei Med J 2017; 58:1047-50.
59
Peters RL, Koplin JJ, Gurrin LC, Dharmage SC, Wake M, Ponsonby AL, et al. HealthNuts Study. The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up. J Allergy Clin Immunol 2017; 140: 145-53.e8.
60
Stratakis N, Roumeliotaki T, Oken E, Ballester F, Barros H, Basterrechea M, et al. Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: a pooled analysis of 18 Europeanand US birth cohorts. Int J Epidemiol 2017; 46: 1465-77.
61
Pontes MV, Ribeiro TC, Ribeiro H, de Mattos AP, Almeida IR, Leal VM, et al. Cow’s milk-based beverage consumption in 1- to 4-year-olds and allergic manifestations: an RCT. Nutr J 2016; 15: 19.
62
Kim SY, Sim S, Park B, Kim JH, Choi HG. High-fat and low-carbohydrate diets are associated with allergic rhinitis but not asthma or atopic dermatitis in children. PLoS One. 2016; 11: e0150202.
63
Park DY, Kim YS, Kim JH, Kang JW. Association of body mass index and other factors with histamine skin reactivity in adults with allergic nasal symptoms. Am J Rhinol Allergy 2015; 29: e160-3.
64
Waidyatillake NT, Stoney R, Thien F, Lodge CJ, Simpson JA, Allen KJ, et al. Breast milk polyunsaturated fatty acids: associations with adolescent allergic disease and lung function. Allergy 2017; 72: 1193-201.
65
Kim J, Han Y, Seo SC, Lee JY, Choi J, Kim KH, et al. Association of carbon monoxide levels with allergic diseases in children. Allergy Asthma Proc 2016; 37: e1-7.
66
Eriksson J, Ekerljung L, Sundblad BM, Lötvall J, Torén K, Rönmark E, et al. Cigarette smoking is associated with high prevalence of chronic rhinitis and low prevalence of allergic rhinitis in men. Allergy 2013; 68: 347-54.
67
Fazlollahi MR, Souzanch G, Nourizadeh M, Sabetkish N, Tazesh B, Entezari A, et al. The prevalence of allergic rhinitis and it’s relationship with second-hand tobacco smoke among adults in Iran. Acta Med Iran 2017; 55: 712-7.
68
Lombardi C, Passalacqua G; Italian Vitamin D Allergy Group. Vitamin D levels and allergic diseases. An italian cross- sectional multicenter survey. Eur Ann Allergy Clin Immunol 2017; 49: 75-9.
69
Bousquet PJ, Combescure C, Neukirch F, Klossek JM, Méchin H, Daures JP, Bousquet Visual analog scales can assess the severity of rhinitis graded according to ARIA Guideline. J Allergy 2007; 62: 367-72.
70
Bousquet J, Van Cauwenberge P, Bachert C, Canonica GW, Demoly P, Durham SR, et al; European Academy of Allergy and Clinical Immunology (EAACI); Allergic Rhinitis and its Impact on Asthma (ARIA). Requirements for medications commonly used in the treatment of allergic rhinitis. European Academy of Allergy and Clinical Immunology (EAACI), Allergic Rhinitis and its Impact onAsthma (ARIA). Allergy 2003; 58: 192-7.
71
Numminen J, Ahtinen M, Huhtala H, Rautiainen M. Comparison of rhinometricmeasurements methods in intranasal pathology. Rhinology 2003; 41: 65-8.
72
Horst M, Hejjaoui A, Horst V, Michel FB, Bousquet J. Double-blind, placebo-controlled rush immunotherapy with a standardized Alternaria extract. J Allergy Clin Immunol 1990; 85: 460-72.
73
Güvenç IA, Ecevit MC. Kronik Rinit ve Rinosinüzitte Subjektif Değerlendirme Yöntemleri: Yaşam Kalitesi Ölçekleri. Turkish J Rhinology 2016; 5: 38-52.
74
Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36).I. Conceptual framework and item selection. Med Care 1992; 30: 473-83.
75
Bousquet J, Bullinger M, Fayol C, Marquis P, Valentin B, Burtin B. Assessment of quality of life in patients with perennial allergic rhinitis with the French version of the SF-36 Health Status Questionnaire. J Allergy Clin Immunol 1994; 94(2 Pt 1): 182-8.
76
Dutt SN, McDermott AL, Jelbert A, Reid AP, Proops DW. The Glasgow benefit inventory in the evaluation of patient satisfaction with the bone-anchored hearing aid: quality of life issues. J Laryngol Otol Suppl 2002; 28: 7-14.
77
van Oene CM, van Reij EJ, Sprangers MA, Fokkens WJ. Quality-assessment of disease- specific quality of life questionnaires for rhini- tis and rhinosinusitis: a systematic review. Allergy 2007; 62: 1359-71.
78
Juniper EF, Thompson AK, Ferrie PJ, Roberts JN. Validation of the standardized version of the Rhinoconjunctivitis Quality of Life Questionnaire. J Allergy Clin Immunol 1999; 104(2 Pt 1): 364-9.
79
Baiardini I, Pasquali M, Giardini A, Specchia C, Passalacqua G, Venturi S, et al. Rhinasthma: a new specific QoL questionnaire for patients with rhinitis and asthma. Allergy 2003; 58: 289-94.
80
Douglas SA, Marshall AH, Walshaw D, Robson AK, Wilson JA. The development of a General Nasal Patient Inventory. Clin Otolaryngol Allied Sci 2001; 26: 425-9.
81
Stewart MG, Witsell DL, Smith TL, Weaver EM, Yueh B, Hannley MT. Development and validation of the Nasal Obstruction Symptom Evaluation (NOSE) scale. Otolaryngol Head Neck Surg 2004; 130: 157-63.
82
Alobid I, Bernal-Sprekelsen M, Mullol J. Chronic rhinosinusitis and nasal polyps: the role of generic and specific questionnaires on assessing its impact on patient’s quality of life. Allergy 2008; 63: 1267-79.
83
Morley AD, Sharp HR. A review of sinonasal outcome scoring systems - which is best? Clin Otolaryngol 2006; 31: 103-9.
84
Hancı D , Altun H , Şahin E , Altıntoprak N , Cingi C . Turkish translation, cross-cultural adaptation and validation of the SinoNasal Outcome Test (SNOT)-22. ENT Updates. 2016; 5: 51-57.
85
Linneberg A, Dam Petersen K, Hahn-Pedersen J, Hammerby E, Serup-Hansen N, Boxall N. Burden of allergic respiratory disease: a systematic review. Clin Mol Allergy. 2016; 14: 12.
86
Demoly P, Bousquet PJ, Mesbah K, Bousquet J, Devillier P. Visual analogue scale in patients treated for allergic rhinitis: an observational prospective study in primary care: asthma and rhinitis. Clin Exp Allergy 2013; 43: 881-888.
87
Meltzer EO. The prevalence and medical and economic impact of allergic rhinitis in the United States. J Allergy Clin Immunol 1997; 99: S805-28.
88
Schatz M, Meltzer EO, Nathan R, Derebery MJ, Mintz M, Stanford RH, et al. Psychometric validation of the rhinitis control assessment test: a brief patient-completed instrument for evaluating rhinitis symptom control. Ann Allergy Asthma Immunol 2010; 104: 118-24.
89
Meltzer EO, Hamilos DL. Rhinosinusitis diagnosis and management for the clinician: a synopsis of recent consensus Guideline. Mayo Clin Proc 2011; 86: 427-43.
90
Bao Y, Chen J, Cheng L, Guo Y, Hong S, Kong W. Chinese Guideline on allergen immunotherapy for allergic rhinitis. Chinese Society of Allergy (CSA) and Chinese Allergic Rhinitis Collaborative Research Group (C2AR2G). J Thorac Dis 2017; 9: 4607-50.
91
Avinçsal M , Altundağ A , Dizdar D , Dinç M , Ulusoy S , Külekçi M . Assessment of chemosensory disorders in allergic rhinitis. ENT Updates. 2017; 7: 82-6.
92
Cheng X, Sheng H, Ma R, Gao Z, Han Z, Chi F, Cong N, Wang J, Liu X, Luo X, Yu J, Ra Y. Allergic rhinitis and allergy are risk factors for otitis media with effusion: A meta-analysis. Allergol Immunopathol (Madr) 2017; 45: 25-32.
93
Oğuzülgen İK. Öksürük Varyant Astım. Turk Thorac J 2013; 14: 9-10.
94
Kar Kurt Ö, Erkoçoğlu M, Kurt M. Pollen food allergy syndrome. Tuberk Toraks 2017; 65: 138-45.
95
Jaruvongvanich V, Mongkolpathumrat P, Chantaphakul H, Klaewsongkram J. Extranasal symptoms of allergic rhinitis are difficult to treat and affect quality of life. Allergol Int 2016; 65: 199-203.
96
Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, et al. Clinical practice guideline: Allergic rhinitis; Guideline Otolaryngology Development Group. AAO-HNSF. Otolaryngol Head Neck Surg 2015; 152(1 Suppl): S1-43.
97
Segboer CL, Holland CT, Reinartz SM, Terreehorst I, Gevorgyan A, Hellings PW,et al. Nasal hyper-reactivity is a common feature in both allergic and nonallergic rhinitis. Allergy 2013; 68: 1427-34.
98
Köse Ş, Mandıracıoğlu A, Tatar BG, Türken M, Topaloğlu S. The Evaluation Of Allergic Diseases In Occupational Groups. Tepecik Eğit Hast Derg 2012; 22: 147-50
99
Bilge U, Unluoglu I, Son N, Keskin A, Korkut Y, Unalacak M. Occupational allergic diseases in kitchen and health care workers: an underestimated health issue. Biomed Res Int. 2013; 2013: 285420.
100
R, McGrath KG. Chapter 6: Nonallergic rhinitis. Allergy Asthma Proc 2012; 33 (Suppl 1): 19-21.
101
Dharma C, Lefebvre DL, Tran MM, Lou WYW, Subbarao P, Becker AB, et al. Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases. Clin Exp Allergy 2018; 48: 48-59.
102
An SY, Choi HG, Kim SW, Park B, Lee JS, Jang JH, et al. Analysis of various risk factors predisposing subjects to allergic rhinitis. Asian Pac J Allergy Immunol 2015; 33: 143-51.
103
Rönmark EP, Ekerljung L, Mincheva R, Sjölander S, Hagstad S, Wennergren G, et al. Different risk factor patterns for adult asthma, rhinitis and eczema: results from West Sweden Asthma Study. Clin Transl Allergy 2016; 6: 28.
104
Tamay Z, Akcay B, Ones U, Guler N, Kilic G, Zencir M. Int J Pediatr Otorhinolaryngol 2007; 71: 463-71.
105
Saulyte J, Regueira C, Montes-Martinez A, Khudyakov P, Takkouche B. Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta-analysis. PLoS Med 2014; 11: e1001611.
106
Chiang TY, Yuan TH, Shie RH, Chen CF, Chan CC. Increased incidence of allergic rhinitis, bronchitis and asthma, in children living near a petrochemical complex with SO2 pollution. Environ Int 2016; 96: 1-7.
107
Chung HY, Hsieh CJ, Tseng CC, Yiin LM. Association between the first occurrence of allergic rhinitis in preschool children and air pollution in Taiwan. Int J Environ Res Public Health 2016; 13: 268.
108
Deng Q, Lu C, Ou C, Chen L, Yuan H. Preconceptional, prenatal and postnatal exposure to outdoor and indoor environmental factors on allergic diseases/symptoms in preschool children. Chemosphere 2016;152: 459-67.
109
Codispoti CD, LeMasters GK, Levin L, Reponen T, Ryan PH, Biagini Myers JM, et al. Traffic pollution is associated with early childhood aeroallergen sensitization. Ann Allergy Asthma Immunol 2015; 114: 126-33.
110
Fuertes E, Brauer M, MacIntyre E, Bauer M, Bellander T, von Berg A, et al. Childhood allergic rhinitis, trafficrelated air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: results from the TAG Study. J Allergy Clin Immunol 2013; 132: 342-52.
111
Duhme H, Weiland SK, Rudolph P, Wienke A, Kramer A, Keil U. Asthma and allergies among children in West and East Germany: a comparison between Münster and Greifswald using the ISAAC phase I protocol. International Study of Asthma and Allergies in Childhood. Eur Respir J 1998;11: 840-7.
112
Norbäck D, Lampa E, Engvall K. Asthma, allergy and eczema among adults in multifamily houses in Stockholm (3-HE study)--associations with building characteristics, home environment and energy use for heating. PLoS One 2014; 9: e112960.
113
Campbell BE, Lodge CJ, Lowe AJ, Burgess JA, Matheson MC, Dharmage SC. Exposure to ‘farming’ and objective markers of atopy: a systematic review and meta-analysis. Clin Exp Allergy 2015; 45: 744-57
114
Özdemir Ö, Elmas B. Variable prevalence of allergic rhinitis and risk factors affecting the prevalence. Kulak Burun Bogaz Ihtis Derg 2016 ; 26: 371-82.
115
Lodge CJ, Lowe AJ, Gurrin LC, Matheson MC, Balloch A, Axelrad C, et al. Pets at birth do not increase allergic disease in at-risk children. Clin Exp Allergy 2012; 42: 1377-85.
116
Schoos AM, Chawes BL, Jelding-Dannemand E, Elfman LB, Bisgaard H. Early indoor aeroallergen exposure is not associated with development of sensitization or allergic rhinitis in high-risk children. Allergy 2016; 71: 684-91.
117
Lampi J, Canoy D, Jarvis D, Hartikainen AL, Keski-Nisula L, Järvelin MR, et al Farming environment and prevalence of atopy at age 31: prospective birth cohort study in Finland. Clin Exp Allergy 2011; 41: 987-93.
118
Alduraywish SA, Lodge CJ, Campbell B, Allen KJ, Erbas B, Lowe AJ, et al. The march from early life food sensitization to allergic disease: a systematic review and meta-analyses of birth cohort studies. Allergy 2016; 71: 77-89.
119
Li Y, Jiang Y, Li S, Shen X, Liu J, Jiang F. Preand postnatal risk factors in relation to allergic rhinitis in school-aged children in China. PLoS One 2015; 10: 0114022.
120
Hahm MI, Chae Y, Kwon HJ, Kim J, Ahn K, Kim WK, et al. Do newly built homes affect rhinitis in children? The ISAAC phase III study in Korea. Allergy 2014; 69: 479-87.
121
Bornehag CG, Sundell J, Hagerhed-Engman L, Sigsggard T, Janson S, Aberg N; DBH Study Group. ‘Dampness’ at home and its association with airway, nose, and skin symptoms among 10,851 preschool )children in Sweden: a cross-sectional study. Indoor Air 2005; 15 Suppl 10: 48-55.
122
Grabenhenrich LB, Keil T, Reich A, et al. Prediction and prevention of allergic rhinitis: a birth cohort study of 20 years. J Allergy Clin Immunol 2015; 136: 932-940.e12.
123
Ahn JC, Kim JW, Lee CH, Rhee CS. Prevalence and risk factors of chronic rhinosinusitus, allergic rhinitis, and nasal septal deviation: results of the Korean National Health and Nutrition Survey 2008-2012. JAMA Otolaryngol Head Neck Surg 2016; 142: 162-7.
124
Lee KS, Rha YH, Oh IH, Choi YS, Choi SH. Socioeconomic and sociodemographic factors related to allergic diseases in Korean adolescents based on the Seventh Korea Youth Risk Behavior Webbased Survey: a cross- sectional study. BMC Pediatr 2016; 16: 19.
125
Penaranda A, Garcia E, Barragan AM, et al. Factors associated with allergic rhinitis in Colombian subpopulations aged 1 to 17 and 18 to 59. Rhinology 2016; 54: 56-67.
126
Torres-Borrego J, Molina-Terán AB, Montes-Mendoza C. Prevalence and associated factors of allergic rhinitis and atopic dermatitis in children. Allergol Immunopathol (Madr) 2008; 36: 90-100.
127
Amberbir A, Medhin G, Hanlon C, Britton J, Davey G, Venn A. Effects of early life paracetamol use on the incidence of allergic disease and sensitization: 5 year follow-up of an Ethiopian birth cohort. PLoS One 2014; 9: e93869.
128
Maslova E, Strøm M, Olsen SF, Halldorsson TI. Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. PLoS One 2013; 8: 57261.
129
Wjst M, Dharmage S, André E, Norback D, Raherison C, Villani S, et al. Latitude, birth date, and allergy. PLoS Med 2005; 2: 294.
130
Sun HL, Lue KH, Ku MS. Neonatal jaundice is a risk factor for childhood allergic rhinitis: a retrospective cohort study. Am J Rhinol Allergy 2013; 27: 192-6.
131
Lodge CJ, Tan DJ, Lau MX, Dai X, Tham R, Lowe AJ, et al. Breastfeeding and asthma and allergies: a systematic review and meta-analysis. Acta Paediatr 2015; 104: 38-53.
132
Mimouni Bloch A, Mimouni D, Mimouni M, Gdalevich M. Does breastfeeding protect against allergic rhinitis during nchildhood? A meta-analysis of prospective studies. Acta Paediatr 2002; 91: 275-9.
133
Thacher JD, Gruzieva O, Pershagen G, Melén E, Lorentzen JC, Kull I, et al. Mold and dampness exposure and allergic outcomes from birth to adolescence: data from the BAMSE cohort. Allergy 2017; 72: 967-74.
134
Lin Z, Norback D, Wang T, Zhang X, Shi J, Kan H, et al. The first 2-year home environment in relation to the new onset and remission of asthmatic and allergic symptoms in 4246 preschool children. Sci Total Environ 2016; 553: 204-10.
135
Skylogianni E, Triga M, Douros K, Bolis K, Priftis KN, Fouzas S, et al. Small-airway dysfunction precedes the development of asthma in children with allergic rhinitis. Allergol Immunopathol (Madr) 2018; 46: 313-21.
136
Settipane RA, Schwindt C. Chapter 15: Allergic rhinitis. Am J Rhinol Allergy 2013 ; 27 Suppl 1: S52-5.
137
Scadding GK, Scadding GW. Diagnostic allergic rhinitis. Immunol Allergy Clin North Am 2016; 36: 249-60.
138
Mims JW. Allergic rhinitis. Facial Plast Surg Clin North Am 2012; 20: 11-20.
139
Doty RL, Mıshra A. Olfaction and its alteration by nasal obstruction, rhinitis, and rhinosinusitis. Laryngoscope 2011; 111: 409-23.
140
Stuck BA, Hummel T. Olfaction in allergic rhinitis: A systematic review. J Allergy Clin Immunol 2015: 136: 1460-70.
141
Eren E, Aktaş A, Arslanoğlu S, Kopar A, Ciğer E, Özkul Y, et al. Diagnosis of allergic rhinitis: inter- rater reliability and predictive value of nasal endoscopic examination: a prospective observational study. Clin Otolaryngol 2013; 38: 481-6.
142
Lakhani N, North M, Ellis AK. Clinical manifestations of allergic rhinitis. J Aller Ther 2012; S5: 007.
143
Blaiss MS. Pediatric allergic rhinitis: physical and mental complications. Allergy Asthma Proc. 2008; 29: 1-6.
144
Spector SL. Overview of comorbid associations of allergic rhinitis. J Allergy Clin Immunol 1997; 99: 773-80.
145
Lacagnina V, Leto-Barone MS, La Piana S, Seidita A, Pingitore G, Di Lorenzo G. Analysis of a database to predict the result of allergy testing in vivo in patients with chronic nasal symptoms. Am J Rhinol Allergy 2014;28: 414-8.
146
van der Zee JS, de Groot H, van Swieten P. Discrepancies between the skin test and IgE antibody assays: study of histamine release, complement activation in vitro, and occurrence of allergen-specific IgG, J Allergy Clin Immunol 2013; 82: 270-9.
147
Wood RA, Phipatanakul W, Hamilton RG, Eggleston PA. A comparison of skin prick tests, intradermal skin tests, and RASTs in the diagnosis of cat allergy, J Allergy Clin Immunol 2013; 103: 773-81.
148
Rive CM, Bourke J, Phillips EJ. Testing for drug hypersensitivity syndromes. Clin Biochem Rev 2013; 34: 15-38.
149
Erel F, Sarioglu N, Kose M, Kaymakci M, Gokcen M, Kepekci AH, et al. Intradermal Skin Testing in Allergic Rhinitis and Asthma with Negative Skin Prick Tests. Iran J Allergy Asthma Immunol 2017; 16: 193-7.
150
Carter ER, Pulos E, Delaney J, Matheson EJ, Moffitt DR. Allergy history does not predict skin test reactivity in asthmatic children. J Asthma 2010; 37: 685-90.
151
Kowalski ML, Ansotegui I, Aberer W, Al-Ahmad M, Akdis M, Ballmer-Weber BK, et al. Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement. World Allergy Organ J 2016; 9: 33.
152
Rao KS, Menon PK, Hilman BC. Duration of the suppressive effect of tricyclic antidepressants on histamine-induced wheal-and-flare reactions in human skin. J Allergy Clin Immunol 2008: 82: 752-7.
153
Des Roches A, Paradis L, Bougeard YH, Godard P, Bousquet J, Chanez P. Long-term oral corticosteroid therapy does not alter the results of immediate-type allergy skin prick tests. J Allergy Clin Immunol 1996; 98: 522-7.
154
Pipkorn U, Hammarlund A, Enerbäck L. Prolonged treatment with topica glucocorticoids results in an inhibition of the allergen-induced weal-and-flare response and a reduction in skin mast cell numbers and histamine content. Clin Exp Allergy 1989; 19: 19-25.
155
Spergel JM, Nurse N, Taylor P, ParneixSpake A. Effect of topical pimecrolimus on epicutaneous skin testing. J Allergy Clin Immunol 2004; 114: 695-7.
156
Skoner DP, Gentile DA, Angelini B, Doyle WJ. Allergy skin test responses during experimental infection with respiratory syncytial virus. Ann Allergy Asthma Immunol 2006; 96: 834-841.
157
Bernstein DI, Wanner M, Borish L, Liss GM and the Immunotherapy Committee of the American Academy of Allergy, Asthma and Immunology. Twelve-year survey of fatal reactions to allergen injections and skin testing. J Allergy Clin Immunol 2014; 113: 1129-36.
158
Nelson HS, Oppenheimer J, Buchmeier. An assessment of the role of intradermal skin testing in the diagnosis of clinically relevant allergy to timothy grass. J Allergy Clin Immunol 2006; 97: 1193-201.
159
Schwindt CD, Hutcheson PS, Leu S-Y, Dykewicz MS. Role of intradermal skin tests in the evaluation of clinically relevant respiratory allergy assessed using patient history and nasal challenges. Ann Allergy Asthma Immunol 2005; 94: 627-33.
160
Indrajana T, Spieksma FT, Voorhorst R. Comparative study of the intracutaneous, scratch and prick tests in allergy. Ann Allergy 1971; 29: 639-50.
161
Dreborg S (editor). Subcommittee on skin tests of the European Academy of Allergology and Clinical Immunology. Skin tests used in type 1 allergy testing- Position paper. Allergy 2009; Supplement 10:1-59.
162
Golden DB, Kagey-Sobotka A, Norman PS, Hamilton RG, Lichtenstein LM. Insect sting allergy with negative venom skin test responses. J Allergy Clin Immunol 2001; 107: 897-901.
163
Rhodius R, Wickens K, Cheng S, Crane J. A comparison of two skin test methodologies and allergens from two different manufacturers. Ann Allergy Asthma Immunol 2002; 88: 374-9.
164
Carr WW, Martin B, DO, Howard RS, Cox L, Borish L. Comparison of test devices for skin prick testing. J Allergy Clin Immunol 2005; 116: 341-6.
165
Piette V, Bourret E, Bousquet J, Demoly P. Prick tests to aeroallergens: Is it possible simply to wipe the device between tests? Allergy 2002; 57: 940-2.
166
Liccardi G, D’Amato G, Walter Canonica G, Salzillo A, Piccolo A, Passalacqua G. Systemic reactions from skin testing: literature review. J Investig Allergol Clin Immunol 2006; 16: 75-8.
167
Clark AT, Ewan PM. Interpretation of tests for nut allergy in one thousand patients, in relation to allergy or tolerance. Clin Exp Allergy 2003; 33: 1041-5.
168
Bıçakçı A, Altunoğlu MK, Bilişik A, Çelenk S, Canıtez Y, et al. Türkiye’nin atmosferik polenleri. Asthma Allergy Immunol 2009; 7: 11-7.
169
Turkeltaub PC, Gergen PJ. The risk of adverse reactions from percutaneous prick-puncture allergen skin testing, venipuncture, and body measurements: data from the second National Health and Nutrition Examination Survey 1976-80 (NHANES II). J Allergy Clin Immunol 1989; 84: 886-90.
170
Roberts G, Lack G. Diagnosing peanut allergy with skin prick and specific IgE testing. J Allergy Clin Immunol 2005; 115: 1291-6.
171
Valyasevi MA, Maddox DE, Li JT. Systemic reactions to allergy skin tests. Ann Allergy Asthma Immunol 1999; 83: 132-6.
172
Devenney I, Falth-Magnusson K. Skin prick tests may give generalised allergic reactions in infants. Ann Allergy Asthma Immunol 2000; 85: 457-60.
173
Novembre E, Bernardini R, Bertini G, Massai G, Vierucci A. Skin-prick-test-induced anaphylaxis. Allergy 1995; 50: 511-3.
174
Kupczyk M, Kupryś I, Górski P, Kuna P. Not one lancet for multiple SPT. Allergy 2001; 56: 256-7.
175
Bernstein IL, Storms WW. Practice parameters for allergy diagnostic testing. Joint Task Force on Practice Parameters for the Diagnosis and Treatment of Asthma. The American Academy of Allergy, Asthma and Immunology and the American College of Allergy, Asthma and Immunology. Ann Allergy Asthma Immunol 1995; 75: 543-625.
176
Nelson HS, Knoetzer J, Bucher B. Effect of distance between sites and region of the body on results of skin prick tests. J Allergy Clin Immunol 1996; 97: 596-601.
177
Radwanski NE, Morris DO, Boston RC, Cerundolo R, Lee KW. Longitudinal evaluation of immunological responses to allergen-specific immunotherapy in horses with IgE associated dermatological disease, a pilot study. Vet Dermatol 2019; 30: 255-e78.
178
Kanthawatana S, Maturim W, Fooanan S, Trakultivakorn M. Skin prick reaction and nasal provocation response in diagnosis of nasal allergy to the house dust mite. Ann Allergy Asthma Immunol 1997; 79: 427-30.
179
Kelso JM. Application of topical corticosteroids to sites of positive immediate-type allergy skin tests to relieve itching: results of a double-blind, placebo-controlled trial. Ann Allergy Asthma Immunol 2007; 98: 182-4.
180
Barnes ML, Vaidyanathan S, Williamson PA, Lipworth BJ. The minimal clinically important difference in allergic rhinitis. Clin Exp Allergy 2010; 40: 242-50.
181
Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M. Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature 2018; 560: 649-54.
182
Ren HL, Li JD, Miao YH, Xu T. Clinical investigation of basophil activation test as a complementary test for house dust mite allergen. Lin Chung 2018; 32: 365-8.
183
Procopiou PA, Ford AJ, Gore PM, Looker BE, Hodgson ST. Design of Phthalazinone Amide Histamine H(1) Receptor Antagonists for Use in Rhinitis. ACS Med Chem Lett 2017; 8: 577-81.
184
Wölbing F, Kunz J, Kempf WE, Grimmel C, Fischer J. The clinical relevance of birch pollen profilin cross-reactivity in sensitized patients. Allergy 2017; 72: 562-9.
185
Leśniak M, Dyga W, Rusinek B, Mazur M, Czarnobilska E. Comparison of the basophil activation test versus the nasal provocation test in establishing eligibility for specific immunotherapy. Pol Arch Med Wewn 2016; 126: 521-9.
186
Bellinghausen I, Saloga J. Analysis of allergic immune responses in humanized mice. Cell Immunol 2016; 308: 7-12.
187
Gilles-Stein S, Beck I, Chaker A, Bas M, McIntyre M. Pollen derived low molecular compounds enhance the human allergen specific immune response in vivo. Clin Exp Allergy 2016; 46: 1355-65.
188
Tolkki L, Alanko K, Petman L, Skydtsgaard MB, Milvang PG. Clinical characterization and IgE profiling of birch (Betula verrucosa)-allergic individuals suffering from allergic reactions to raw fruits and vegetables. J Allergy Clin Immunol Pract 2013; 1: 623-31.
189
Kleinjan A, van Nimwegen M, Leman K, Hoogsteden HC, Lambrecht BN. Topical treatment targeting sphingosine- 1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model. Allergy 2013; 68: 204-12.
190
García-Gallardo MV, Algorta J, Longo N, Espinel S, Aragones A, et al. Evaluation of the effect of pollution and fungal disease on Pinus radiata pollen allergenicity. Int Arch Allergy Immunol 2013; 160: 241-50.
191
Hussain MM, Mandal J, Bhattacharya K. Airborne load of Cassia pollen in West Bengal, eastern India: its atmospheric variation and health impact. Environ Monit Assess 2013; 185: 2735-44.
192
Di Lorenzo G, Leto-Barone MS, La Piana S, Ditta V, Di Fede G, Rini GB. Clinical course of rhinitis and changes in vivo and in vitro of allergic parameters in elderly patients: a long-term follow-up study. Clin Exp Med 2013; 13: 67-73.
193
Romano A, Caubet JC. Antibiotic allergies in children and adults: from clinical symptoms to skin testing diagnosis. J Allergy Clin Immunol Pract 2014; 2: 3-12.
194
Moed H, Gerth van Wijk R, Hendriks RW, van der Wouden JC. Evaluation of clinical and immunological responses: a 2-year follow-up study in children with allergic rhinitis due to house dust mite. Mediators Inflamm 2013; 2013: 345217.
195
Barberini S, Della Rocca G, Danti R, Zanoni D, Mori B, Ariano R, et al. Different allergenicity of pollen extracts of three Mediterranean cypress species accounted for cytological observations. Eur Ann Allergy Clin Immunol 2015; 47: 149-55.
196
Campo P, Villalba M, Barrionuevo E, Rondón C, Salas M. Immunologic responses to the major allergen of Olea europaea in local and systemic allergic rhinitis subjects. Clin Exp Allergy 2015; 45: 1703-12.
197
https://www.allergy.org.au/images/ASCIA_HP_SPT_Guide_2020.pdf (cited 2020 December 11)
198
Makhija M, O’Gorman MRG. Chapter 31: Common in vitro tests for allergy and immunology. Allergy Asthma Proc 2012; 33 Suppl 1: 108-11.
199
Stone KD, Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 2010; 125: S73-80.
200
Sharma S, Kathuria PC, Gupta CK, Nordling K, Ghosh B, Singh AB. Total serum immunoglobulin E levels in a case- control study in asthmatic/allergic patients, their family members, and healthy subjects from India. Clin Exp Allergy 2006; 36: 1019-27.
201
Villalta D, Da Re M, Conte M, Martelli P, Uasuf CG, Barrale M, et al. Allergen component specific ige measurement with the Immulite 2000 system: diagnostic accuracy and intermethod comparison. J Clin Lab Anal 2015; 29: 135-41.
202
Cobbaert CM, Jonker GJ. Allergy testing on the IMMULITE 2000 Random-Access immunoanalyzer - a clinical evaluation study. Clin Chem Lab Med 2005; 43: 772-81.
203
Ahlstedt S, Murray CS. In vitro diagnosis of allergy: how to interpret IgE antibody results in clinical practice. Prim Care Respir J 2006; 15: 228-36.
204
Chinoy B, Yee E, Bahna SL. Skin testing versus radioallergosorbent testing for indoor allergens. Clin Mol Allergy 2005; 3: 4.
205
Rossi RE, Monasterolo G. Evaluation of recombinant and native timothy pollen (rPhl p 1, 2, 5, 6, 7, 11, 12 and nPhl p 4)- specific IgG4 antibodies induced by subcutaneous immunotherapy with timothy pollen extract in allergic patients. Int Arch Allergy Immunol 2004; 135: 44-53.
206
Cudowska B, Kaczmarski M. Diagnostic value of birch recombinant allergens (rBet v 1, profilin rBet v 2) in children with pollen-related food allergy. Rocz Akad Med Bialymst 2004; 49: 111-5.
207
Quiralte J, Llanes E, Barral P, Arias de Saavedra JM, Saenz de San Pedro B, Villalba M, et al. Ole e 2 and Ole e 10: new clinical aspects and genetic restrictions in olive pollen allergy. Allergy 2005; 60: 360-5.
208
Simpson A, Soderstrom L, Ahlstedt S, Murray CS, Woodcock A, Custovic A. IgE antibody quantification and the probability of wheeze in preschool children. J Allergy Clin Immunol. 2005; 116: 744-9.
209
Stern A, van Hage-Hamsten M, Sondell K, Johansson SG. Is allergy screening of blood donors necessary? A comparison between questionnaire answers and the presence of circulating IgE antibodies. Vox Sang 1995; 69: 114-9.
210
Ott H, Schroder CM, Stanzel S, Merk HF, Baron JM. Microarray-based IgE detection in capillary blood samples of patients with atopy. Allergy 2006; 61: 1146-7.
211
Treudler R, Simon JC. Overview of component resolved diagnostics. Curr Allergy Asthma Rep 2013; 13: 110-7.
212
Lizaso MT, Garcia BE, Tabar AI, Lasa E, Echechipia S, Alvarez MJ, et al. Comparison of conventional and component-resolved diagnostics by two different methods (Advia-Centaur/Microarray-ISAC) in pollen allergy. Ann Allergy Asthma Immunol 2011; 107: 35-41.
213
Westwood M, Ramaekers B, Lang S, Armstrong N, Noake C, de Kock S, et al. ImmunoCAP(R) ISAC and Microtest for multiplex allergen testing in people with difficult to manage allergic disease: a systematic review and cost analysis. Health Technol Assess 2016; 20: 1-178.
214
Sainte-Laudy J, Boumediene A, Touraine F, Orsel I, Brianchon C, Bonnaud F, et al. Use of both CD63 up regulation and IgE down regulation for the flow cytometric analysis of allergen induced basophil activation. Definition of an activation index. Inflamm Res 2007; 56: 291-6.
215
Ogulur I, Kiykim A, Baris S, Ozen A, Yuce EG, Karakoc-Aydiner E. Basophil activation test for inhalant allergens in pediatric patients with allergic rhinitis. Int J Pediatr Otorhinolaryngol 2017; 97: 197-201.
216
Bochner BS, Sterbinsky SA, Knol EF, Katz BJ, Lichtenstein LM, MacGlashan DW, Jr., et al. Function and expression of adhesion molecules on human basophils. J Allergy Clin Immunol 1994; 94: 1157-62.
217
Nopp A, Johansson SG, Ankerst J, Bylin G, Cardell LO, Gronneberg R, et al. Basophil allergen threshold sensitivity: a useful approach to anti-IgE treatment efficacy evaluation. Allergy 2006; 61: 298-302.
218
Nolte H, Storm K, Schiotz PO. Diagnostic value of a glass fibre-based histamine analysis for allergy testing in children. Allergy 1990; 45: 213-23.
219
Boumiza R, Monneret G, Forissier MF, Savoye J, Gutowski MC, Powell WS, et al. Marked improvement of the basophil activation test by detecting CD203c instead of CD63. Clin Exp Allergy 2003; 33: 259-65.
220
Hamilton RG, Franklin Adkinson N, Jr. In vitro assays for the diagnosis of IgE-mediated disorders. J Allergy Clin Immunol 2004; 114: 213-25
221
Ahn JY, Hong SJ, Choi BS. Clinical Evaluation of Techniques for Measuring Nasal-Specific Immunoglobulin E in Pediatric Patients. J Korean Med Sci 2017; 32: 2005-8.
222
Jang TY, and Kim YH. Nasal provocation test is useful for discriminating allergic, nonallergic, and local allergic rhinitis. Am J Rhinol Allergy 2015; 29: 100-104.
223
Dordal MT, Lıuch-Bernal M, Sanchez MC, Rondon C, Navarro A, Montoro J et al. Allergen- specific nasal provocation testing: Review by the rhinoconjunctivitis comittee of the spanish Society of allergy and clinical immunology. J Investig Allergol Clin Immunol 2011; 21: 1-12.
224
Matsumoto FY, Gonçalves TR, Sole D, Wandalsen GF. Specific nasal provocation test with Dermatophagoides pteronyssinus, monitored by acoustic rhinometry, in children with rhinitis. Am J Rhinol Allergy 2017; 31: 7-11.
225
de Blay F, Doyen V, Lutz C, Godet J, Barnig C, Qi S, Braun JJ. A new, faster, and safe nasal provocation test method for diagnosing mite allergic rhinitis. Ann Allergy Asthma Immunol 2015; 115: 385-390.
226
Gomez F, Rondon C, Salas M, Campo P. Local allergic rhinitis: mechanisms, diagnosis and relevance for occupational rhinitis. Curr Opin Allergy Clin Immunol 2015; 15: 111-6.
227
Van Hage-Hamsten M, Pauli G. Provocation testing with recombinant allergens. Methods 2004; 32: 281-91.
228
Howarth PH, Persson CGA, Metlzer EO, Jacobson MR, Durham SR, Silkoff PE. Objective monitoring of nasal airway inflammation in rhinitis. J Allergy Clin Immunol 2005; 115: 414-41.
229
Caimmi D, Baiz N, Tanno LK, Demoly P, Arnavielhe S, Murray R. Validation of the MASK-rhinitis visual analogue scale on smartphone screens to assess allergic rhinitis control Clin Exp Allergy 2017; 47: 1526-33.
230
Kirtsreesakul V, Somjareonwattana P, Ruttanaphol S. The correlation between nasal symptom and mucociliary clearance in allergic rhinitis. Laryngoscope 2009; 119: 1458-62.
231
Clement PAR, Halewyck S, Gordts F, Michel O. Critical of different objective techniques of nasal airway assessment: A clinical review. Eur Arch Otorhinolaryngol 2014; 271: 2617-25.
232
Hilberg O. Objective measurement of nasal airway dimensions using acoustic rhinometry: methodological and clinical aspects. Allergy 2002; 57: 5-39.
233
Aoishi K, Takahashi H, Hato N, Gyo K, Yokota M, Ozaki S, et al. Treatment of allergic rhinitis with intranasal infusion of botulinum toxin type A in mice. Life Sci 2016; 147: 132-6.
234
Scadding G, Scadding GK. Update on the use of nitric oxide as a noninvasive measure of airways inflammation. Rhinology 2009; 47: 115-20.
235
Autio TJ, Koskenkorva T, Koivunen P, Alho OP. Inflammatory biomakers during bacterial acute rhinosinusitis. Curr Allergy Asthma Rep 2018; 18: 13.
236
Ma Y,Shi L, Zheng C. Microarray analysis of lncRNA mRNA expression profiles in mice with allergic rhinitis. Int J of Pediatr Otorhinolaryngol 2018; 104: 58-65.
237
Bonifazi F, Bilò MB, Antonicelli L, Bonetti MG. Rhinopharyngoscopy, computed tomography and magnetic resonance imaging. Allergy 1997; 52: 28-31.
238
Racette SD, Wijewickrama RC, Jayaprakash V, Sherris DA, Santos C, Kita H, et al. Correlation of Symptoms, Clinical Signs, and Biomarkers of Inflammation in Postsurgical Chronic Rhinosinusitis. Ann Otol Rhinol Laryngol 2017; 126: 455-62.
239
Berrettini S, Carabelli A, Sellari-Franceschini S, Bruschini L, Abruzzese A, Quartieri F, et al. Perenial allergic rhinitis and chronic sinusitis: correlation with rhinologic risk factors. Allergy 1999; 54: 242-8.
240
Benninger MS, Sindwani R, Holy CE, Hopkins C. Early versus delayed endoscopic sinus surgery in patients with chronic rhinosinusitis: Impact on health care utilization. Otolaryngol Head Neck Surg 2015; 152: 546-52.
241
Koskinen A, Numminen J, Markkola A, Karjalainen J, Karstila T, Julkunen A, et al. Diagnostic Accuracy of Symptoms, Endoscopy, and Imaging Signs of Chronic Rhinosinusitis Without Nasal Polyps Compared to Allergic Rhinitis. Am J Rhinol Allergy 2018; 32: 121-31.
242
Jankowski R, Rumeau C, Gallet P, Nguyen DT. Nasal polyposis (or chronic olfactory rhinitis). Eur Ann Otorhinolaryngol Head Neck Dis 2018; 135: 191-6.
243
Pulickal GG, Navaratnam AV, Nguyen T, Dragan AD, Dziedzic M, Lingam RK. Imaging Sinonasal disease with MRI: Providing insight over and above CT. Eur J Radiol 2018; 102: 157-68.
244
Feng CH, Miller MD, Simon RA. The united allergic airway: connections between allergic rhinitis, asthma, and chronic sinusitis. Am J Rhinol Allergy 2012; 26: 187-90.
245
Mhurchu EN, Ospina J, Janjua AS, Shewchuk JR, Vertinsky AT. Fungal Rhinosinusitis: A Radiological Review With Intraoperative Correlation. Can Assoc Radiol J 2017; 68: 178-1.
246
Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, et al. The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 2016; 22: 1-84.
247
Tran NP, Vickery J, Blaiss MS. Management of Rhinitis: Allergic and Non-Allergic. Allergy Asthma Immunol Res 2011; 3: 148-56.
248
Bachert C. Persistent rhinitis - allergic or nonallergic? Allergy 2004; 59: 11-5; discussion 15.
249
Brandt D, Bernstein JA. Questionnaire evaluation and risk factor identification for nonallergic vasomotor rhinitis. Ann Allergy Asthma Immunol 2006; 96: 526-32.
250
Wilson, KF, Spector, ME, Orlandi, RR. Types of rhinitis. Otolaryngol Clin North Am 2011; 44: 549-59.
251
Bernstein JA, Singh U. Neural Abnormalities in Nonallergic Rhinitis. Curr Allergy Asthma Rep 2015; 15: 18.
252
Lung MA. The role of the autonomic nerves in the control of nasal circulation. Biol Signals 1995; 4: 179-85.
253
Greiwe J, Bernstein JA. Nonallergic Rhinitis: Diagnosis. Immunol Allergy Clin North Am 2016; 36: 289-303.
254
Baraniuk JN. Pathogenic Mechanisms of Idiopathic Nonallergic Rhinitis. World Allergy Organ J 2009; 2: 106-14.
255
Baraniuk JN. Neurogenic mechanisms in rhinosinusitis. Curr Allergy Asthma Rep 2001; 1: 252-61.
256
Settipane RA1, Lieberman P. Update on nonallergic rhinitis. Ann Allergy Asthma Immunol 2001; 86: 494-507
257
Rondón C, Doña I, Torres MJ, Campo P, Blanca M. Evolution of patients with nonallergic rhinitis supports conversion to allergic rhinitis. J Allergy Clin Immunol 2009; 123: 1098-102.
258
Kaliner MA. Classification of Nonallergic Rhinitis Syndromes with a Focus on Vasomotor Rhinitis, Proposed to be Known henceforth as Nonallergic Rhinopathy. The World Allergy Organization Journal 2009; 2: 98-101.
259
Settipane RA, Kaliner MA. Nonallergic rhinitis. Am J Rhinol Allergy 2013; 27: S48-51.
260
Kaliner MA. Nonallergic rhinopathy (formerly known as vasomotor rhinitis). Immunol Allergy Clin North Am 2011; 31: 441-55.
261
Leone C, Teodoro C, Pelucchi A, Mastropasqua B, Cavigioli G, Marazzini L, et al. Bronchial responsiveness and airway inflammation in patients with nonallergic rhinitis with eosinophilia syndrome. J Allergy Clin Immunol 1997; 100: 775-80.
262
Scadding GK, Kariyawasam HH, Scadding G, Mirakian R, Buckley RJ, Dixon T, et al. BSACI guideline for the diagnosis and management of allergic and non-allergic rhinitis (Revised Edition 2017; First edition 2007). Clin Exp Allergy 2017; 47: 856-89.
263
Raphael G, Raphael MH, and Kaliner M. Gustatory rhinitis: A syndrome of food-induced rhinorrhea. J Allergy Clin Immunol 1989; 83:110-5.
264
Ellegård E, Hellgren M, Torén K, Karlsson G. The incidence of pregnancy rhinitis. Gynecol Obstet Invest 2000; 49: 98-101.
265
Sobol SE, Frenkiel S, Nachtigal D, Wiener D, Teblum C. Clinical manifestations of sinonasal pathology during pregnancy. J Otolaryngol 2001; 30: 24-8.
266
Moore EJ, Kern EB. Atrophic rhinitis: a review of 242 cases. Am J Rhinol 2001; 15: 355-61.
267
Marshall AH, Jones NS, Robertson IJ. CSF rhinorrhoea: the place of endoscopic sinus surgery. Br J Neurosurg 2001; 15: 8-12.
268
Quillen DM, Feller DB. Diagnosing rhinitis: allergic vs. nonallergic. Am Fam Physician 2006; 73: 1583-90.
269
Di Lorenzo G, Pacor ML, Amodio E, Leto-Barone MS, La Piana S, D’Alcamo A, et al. Differences and similarities between allergic and nonallergic rhinitis in a large sample of adult patients with rhinitis symptoms. Int Arch Allergy Immunol 2011; 155: 263-70.
270
Kaliner MA, Baraniuk JN, Benninger MS, Bernstein JA, Lieberman P, Meltzer EO, et al. Consensus Description of Inclusion and Exclusion Criteria for Clinical Studies of Nonallergic Rhinopathy (NAR), Previously Referred to as Vasomotor Rhinitis (VMR), Nonallergic Rhinitis, and/or Idiopathic Rhinitis. World Allergy Organ J 2009; 2: 180-4.
271
Dion GR, Weitzel EK, McMains KC. Current approaches to diagnosis and management of rhinitis. South Med J 2013; 106: 526-31.
272
Alves A, Martins C, Delgado L, Fonseca J, Moreira A. Exercise-induced rhinitis in competitive swimmers. Am J Rhinol Allergy 2010; 24: e114-7.
273
Beard S. Rhinitis. Prim Care 2014; 41: 33-46.
274
Scadding GK, Scadding GW. Diagnosing Allergic Rhinitis. Immunol Allergy Clin North Am 2016; 36: 249-60.
275
Lieberman P, Pattanaik D. Nonallergic rhinitis. Curr Allergy Asthma Rep 2014; 14: 439.
276
Varghese M, Glaum MC, Lockey RF. Drug-induced rhinitis. Clin Exp Allergy 2010; 40: 381-4.
277
https://www.aid.org.tr/forms/rehberler/1-Allerjik%20Rinit%20Tani%20ve%20Tedavi%20Rehberi%202012.pdf (cited 2020 December 11)
278
Garavello W, Somigliana E, Acaia B, Gaini L, Pignataro L, Gaini RM. Nasal lavage in pregnant women with seasonal allergic rhinitis: a randomized study. Int Arch Allergy Immunol 2010; 151: 137-41.
279
Flovent [package insert]. Philadelphia: GlaxoSmithKline; 2010. http:// www.fda.gov/downloads/ AdvisoryCommittees/CommitteesMeetingMaterials/ PediatricAdvisoryCommittee/UCM235282.pdf. (cited 2020 December 11)
280
Horak F, Zieglmayer UP. Azelastine nasal spray for the treatment of allergic and nonallergic rhinitis. Expert Rev Clin Immunol 2009; 5: 659-69.
281
Wilson KF, Spector ME, Orlandi RR. Types of rhinitis. Otolaryngol Clin North Am 2011; 44: 549-59.
282
Braunstahl GJ. United airways concept: what does it teach us about systemic inflammation in airways disease? Proc Am Thorac Soc 2009; 6: 652-4.
283
Cingi C, Gevaert P, Mösges R, Rondon C, Hox V, Rudenko M. Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force Report. Clin Transl Allergy 2017; 7: 17.
284
Leynaert B, Neukirch C, Kony S, Guénégou A, Bousquet J, Aubier M, et al. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol 2004; 113: 86-93.
285
Kou W, Li X, Yao H, Wei P. Meta-analysis of the comorbidity rate of allergic rhinitis and asthma in Chinese children. Int J Pediatr Otorhinolaryngol 2018; 107: 131-4.
286
Zhang Y, Zhang L. Prevalence of allergic rhinitis in china. Allergy Asthma Immunol Res 2014; 6: 105-13.
287
Di Cara G, Carelli A, Latini A, Panfili E, Bizzarri I, Ciprandi G, et al. Severity of allergic rhinitis and asthma development in children. World Allergy Organ J 2015; 8: 13.
288
Samitas K, Carter A, Kariyawasam HH, Xanthou G. Upper and lower airway remodelling mechanisms in asthma, allergic rhinitis and chronic rhinosinusitis: The one airway concept revisited. Allergy 2017; 00: 1-10.
289
Laitinen A, Laitinen LA. Airway morphology: epithelium/basement membrane. Am J Respir Crit Care Med 1994; 150: S14-7.
290
Beers MF, Morrisey EE. The three R’s of lung health and disease: repair, remodeling, and regeneration. J Clin Invest 2011; 121: 2065-73.
291
Bhimrao SK, Wilson SJ, Howarth PH. Airway inflammation in atopic patients: a comparison of the upper and lower airways. Otolaryngol Head Neck Surg 2011; 145: 396-400.
292
Lim MC, Taylor RM, Naclerio RM. The histology of allergic rhinitis and its comparison to cellular changes in nasal lavage. Am J Respir Crit Care Med 1995; 151: 136-44.
293
Eifan AO, Orban NT, Jacobson MR, Durham SR. Severe Persistent Allergic Rhinitis. Inflammation but No Histologic Features of Structural Upper Airway Remodeling. Am J Respir Crit Care Med 2015; 192: 1431-9.
294
Amin K, Rinne J, Haahtela T, Simola M, Peterson CG, Roomans GM, et al. Inflammatory cell and epithelial characteristics of perennial allergic and nonallergic rhinitis with a symptom history of 1 to 3 years’ duration. J Allergy Clin Immunol 2001; 107: 249-57.
295
Aguilar D, Pinart M, Koppelman GH, Saeys Y, Nawijn MC, Postma DS, et al. Computational analysis of multimorbidity between asthma, eczema and rhinitis. PLoS One 2017; 12: e0179125.
296
Lohia S, Schlosser RJ, Soler ZM. Impact of intranasal corticosteroids on asthma outcomes in allergic rhinitis: a meta-analysis. Allergy 2013; 68: 569-79.
297
Meltzer EO.Role for cysteinyl leukotriene receptor antagonist therapy in asthma and their potential role in allergic rhinitis based on the concept of “one linked airway disease”. Ann Allergy Asthma Immunol 2000; 84: 176-85.
298
Elliott J, Kelly SE, Johnston A, Skidmore B, Gomes T, Wells GA. Allergen immunotherapy for the treatment of allergic rhinitis and/or asthma: an umbrella review. CMAJ Open 2017; 5: E373-E385.
299
Möller C, Dreborg S, Ferdousi HA, Halken S, Høst A, Jacobsen L, Koivikko A et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol 2002; 109: 251-6.
300
Karakoc-Aydiner E, Eifan AO, Baris S, Gunay E, Akturk E, Akkoc T, et al. Long-term effect of sublingual and subcutaneous immunotherapy in dust mite-allergic children with asthma/rhinitis: A 3-Year Prospective Randomized Controlled Trial. J Investig Allergol Clin Immunol 2015; 25: 334-42.
301
Morjaria JB, Caruso M, Emma R, Russo C, Polosa R. Treatment of allergic rhinitis as a strategy for preventing asthma. Curr Allergy Asthma Rep 2018; 18: 23.
302
Fokkens W, Desrosiers M, Harvey R, Hopkins C, Mullol J, Philpott C, et al. EPOS 2020: development strategy and goals for the latest European Position Paper on Rhinosinusitis. Rhinology 2019; 57: 162-8.
303
Halderman AA, Tully LJ. The Role of Allergy in Chronic Rhinosinusitis. Otolaryngol Clin North Am 2017; 50: 1077-90.
304
Ibáñez MD, Valero AL, Montoro J, Jauregui I, Ferrer M, Dávila I, et al. Analysis of comorbidities and therapeutic approach for allergic rhinitis in a pediatric population in Spain. Pediatr Allergy Immunol 2013; 24: 678-84.
305
Hoffmans R, Wagemakers A, van Drunen C, Hellings P, Fokkens W. Acute and chronic rhinosinusitis and allergic rhinitis in relation to comorbidity, ethnicity and environment. PLoS One 2018; 13: e0192330.
306
Yoo KH, Ahn HR, Park JK, Kim JW, Nam GH, Hong SK et al. Burden of Respiratory Disease in Korea: An Observational Study on Allergic Rhinitis, Asthma, COPD, and Rhinosinusitis. Allergy Asthma Immunol Res 2016; 8: 527-34.
307
Furukawa CT. The role of allergy in sinusitis in children. J Allergy Clin Immunol 1992; 90: 515-7.
308
Mbarek C, Akrout A, Khamassi K, Ben Gamra O, Hariga I, Ben Amor M, et al. Recurrent upper respiratory tract infections in children and allergy. A crosssectional study of 100 Cases.Tunis Med 2008; 86: 358-61.
309
Naclerio R, Blair C, Yu X, Won YS, Gabr U, Baroody FM. Allergic rhinitis augments the response to a bacterial sinus infection in mice: A review of an animal model. Am J Rhinol 2006; 20: 524-33.
310
Blair C, Nelson M, Thompson K, Boonlayangoor S, Haney L, Gabr U, et al. Allergic inflammation enhances bacterial sinusitis in mice. J Allergy Clin Immunol 2001; 108: 424-9.
311
Lin SW, Wang YH, Lee MY, Ku MS, Sun HL, Lu KH et al. Clinical spectrum of acute rhinosinusitis among atopic and nonatopic children in Taiwan. Int J Pediatr Otorhinolaryngol 2012; 76: 70-5.
312
Leo G, Incorvaia C, Cazzavillan A, Consonni D, Zuccotti GV. Could seasonal allergy be a risk factor for acute rhinosinusitis in children? J Laryngol Otol 2018; 132: 150-3.
313
Pant H, Ferguson BJ, Macardle PJ. The role of allergy in rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 2009; 17: 232-8.
314
Melvin TA, Lane AP, Nguyen MT, Lin SY. Allergic rhinitis patients with recurrent acute sinusitis have increased sinonasal epithelial cell TLR9 expression. Otolaryngology-head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery 2010; 142: 659-64.
315
Vlastos I, Athanasopoulos I, Mastronikolis NS, Panogeorgou T, Margaritis V, Naxakis S, Goumas PD. Impaired mucociliary clearance in allergic rhinitis patients is related to a predisposition to rhinosinusitis. Ear Nose Throat J 2009; 88: E17-9.
316
Kirtsreesakul V, Ruttanaphol S. The relationship between allergy and rhinosinusitis. Rhinology 2008; 46: 204-8.
317
Ramadan HH, Fornelli R, Ortiz AO, Rodman S. Correlation of allergy and severity of sinus disease. Am J Rhinol 1999; 13: 345-7.
318
Gelincik A, Büyüköztürk S, Aslan I, Aydin S, Ozşeker F, Colakoğlu B, et al. Allergic vs nonallergic rhinitis: which is more predisposing to chronic rhinosinusitis? Ann Allergy Asthma Immunol 2008; 101: 18-22.
319
Sedaghat AR, Phipatanakul W, Cunningham MJ.Atopy and the development of chronic rhinosinusitis in children with allergic rhinitis. J Allergy Clin Immunol Pract 2013; 1: 689-91.
320
Baroody FM, Mucha SM, Detineo M, Naclerio RM. Nasal challenge with allergen leads to maxillary sinus inflammation. The Journal of al- lergy and clinical immunology 2008; 121: 1126-32.
321
DeYoung K, Wentzel JL, Schlosser RJ, Nguyen SA, Soler ZM. Systematic review of immunotherapy for chronic rhinosinusitis. Am J Rhinol Allergy 2014; 28: 145-50.
322
Bachert C, Zhang N, Holtappels G, De Lobel L, van Cauwenberge P, Liu S, et al. Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. J Allergy Clin Immunol 2010; 126: 962-8.
323
Pumhirun P, Limitlaohapanth C, Wasuwat P. Role of allergy in nasal polyps of Thai patients. Asian Pac J Allergy Immunol 1999; 17: 13-5.
324
Settipane GA, Chafee FH. Nasal polyps in asthma and rhinitis. A review of 6,037 patients. J Allergy Clin Immunol 1977; 59: 17-21.
325
Pang YT, Eskici O, Wilson JA. Nasal polyposis: role of subclinical delayed food hypersensitivity. Otolaryngol Head Neck Surg 2000; 122: 298-301.
326
Tan BK, Zirkle W, Chandra R, et al. Atopic profile of patients failing medical therapy for chronic rhinosinusitis. Int Forum Allergy Rhinol 2011; 1: 88-94.
327
Erbek SS, Erbek S, Topal O, Cakmak O. The role of allergy in the severity of nasal polyposis. Am J Rhinol 2007; 21: 686-90.
328
Görgülü O, Ozdemir S, Canbolat EP, Sayar C, Olgun MK, Akbaş Y. Analysis of the roles of smoking and allergy in nasal polyposis. Ann Otol Rhinol Laryngol 2012; 121: 615-9.
329
Bousquet J, Schünemann HJ, Samolinski B, Demoly P, Baena-Caqnani CE, Bachert C, et al. Allergic Rhinitis and its Impact on Astma (ARIA): achievements in 10 years and future needs. J Allergy Clin Immunol 2012; 130: 1049-62.
330
Mantelli F, Lambiase A, Bonini S. A simple and rapid diagnostic algorithm for the detection of ocular allergic diseases. Curr Opin Allergy Clin Immun 2009; 9: 471-6.
331
Bonini S, Gramiccioni C, Bonini M, Bresciani M. Practical approach to diagnosis and treatment of ocular allergy: a 1-year systematic review. Curr Opin Allergy Clin Immunol 2007; 7: 446-9.
332
Friedlaender MH. Ocular allergy. Curr Opin Allergy Immunol 2011; 11: 477-82.
333
Ono SJ, Abelson MB. Jun J, Bielory L, Raizman MB. Vernal conjunctivitis. Immunol Allergy Clin North Am 2008; 28: 59-82.
334
Leonardi A, Motterle L, Bortolotti M. Allergy and the eye. Clin Exp Immunol 2008; 153: S17-21.
335
Jun J, Bielory L, Raizman MB. Vernal conjunctivitis. Immunol Allergy Clin North Am 2008;28: 59-82.
336
Elhers WH, Donshik PC. Giant papillary conjunctivitis. Curr Opin Allergy Clin Immunol 2008; 8: 445-9.
337
Sih T, Mion O. Allergic rhinitis in the child and associated comorbidities. Pediatr Allergy Immunol 2010; 21: e107-13.
338
Lack G, Caulfield H, Penagos M. The link between otitis media with effusion and allergy: a potential role for intranasal corticosteroids. Pediatr Allergy Immunol 2011; 22: 258-66.
339
Rosenfeld RM, Culpepper L, Doyle KJ, Grundfast KM, Hoberman A, Kenn MA et al. Clinical practice guideline: Otitis media with effusion. Otolaryngol Head Neck Surg 2004; 130: S95-118.
340
Nguyen P, Manoukian JJ, Tewfik TL, Sobol SE, Joubert P, Mazer BD et al. Evidence of allergic inflammation in the middle ear and nasopharynx in atopic children with otitis media with effusion. J Otolaryngol 2004; 33: 345-51.
341
Tewfik TL, Mazer B. The links berween allergy and otitis media with effusion. Curr Opin Otolaryngol Head Neck Surg 2006; 14: 187-90.
342
Luong A, Roland PS. The link between allergic rhinitis and chronic otitis media with effusion in atopic patients. Otolaryngol Clin North Am 2008; 41: 311-23.
343
Criscuoli G, D’Amora S, Ripa G, Cinquegrana G, Mansi N, Impagliazzo N, et al. Frequency of surgery among children who have adenotonsillar hypertrophy and improve after treatment with nasal beclomethasone. Pediatrics 2003; 111: e236-8.
344
Meltzer EO, Blaiss MS, Naclerio RM, Stoloff SW, Derebery MJ, Nelson HS et al. Burden of allergic rhinitis: allergies in America, Latin America, and Asia-Pasific adult surveys. Allergy Asthma Proc 2012; 33: S113-41.
345
Flook EP, Kumar BN. Is there evidence to link acid reflux with chronic sinusitis or any nasal symptoms? A review of the evidence. Rhinology 2011; 49: 11-6.
346
Straumann A, Aceves SS, Blanchard C, Collins MH, Furuta GT, Hirano I et al. Pediatric and adult eosinophilic esophagitis: similarities and differences. Allergy 2012; 67: 477-90.
347
Simon D, Marti HP, Heer P, Simon HU, Braathen LR, Straumann A. Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases. J Allergy Clin Immunol 2005; 115: 1090-2.
348
Almansa C, Krishna M, Buchner AM, Ghabril MS, Talley N, DeVault KR et al. Seasonal distribution in newly diagnosed cases of eosinophilic esophagitis in adults. Am J Gastroenterol 2009; 104: 828-33.
349
Newton J, Furuta GT, Atkins D, Spomer K. Eosinophilic esophagitis: recognizing the clues. Gastroenterol Nurs 2011; 34: 147-52.
350
Spergel JM, Brown-Whitehorn TF, Beausoleil JL, Franciosi J, Shuker M, Verma R et al. 14 years of eosinophilic esophagitis: clinical features and prognosis. J Pediatr Gastroenterol Nutr 2009; 48: 30-6.
351
Ali Mel-S. Laryngopharyngeal reflux: diagnosis and treatment of a controversial disease. Curr Opin Allergy Clin Immunol 2008; 8: 28-33.
352
Ozmen S, Yücel OT, Sinici I, Ozmen OA, Süslü AE, Oğretmenoğlu O et al. Nasal pepsin assay and pH monitoring in chronic rhinosinusitis. Laryngoscope 2008; 118: 890-4.
353
Evcimik MF, Dogru M, Cirik AA, Nepesov MI. Adenoid hypertrophy in children with allergic disease and influential factors. Int J Pediatr Otorhinolaryngol 2015; 79: 694-7.
354
Said SA, Mchembe MD, Chalya PL, Rambau P, Gilyoma JM. Allergic rhinitis and its associated co-morbidities at Bugando Medical Centre in Northwestern Tanzania; A prospective review of 190 cases. BMC Ear Nose Throat Disord 2012; 12: 13.
355
Mariño-Sánchez F, Valls-Mateus M, Cardenas-Escalante P, Haag O, Ruiz-Echevarría K, Jiménez-Feijoo R, et al. Influence of nasal septum deformity on nasal obstruction, disease severity, and medical treatment response among children and adolescents with persistent allergic rhinitis. Int J Pediatr Otorhinolaryngol 2017; 95: 145-154.
356
Mariño-Sánchez FS, Valls-Mateus M, Ruiz-Echevarría K, Alobid I, Cardenas-Escalante P, Jiménez-Feijoo R, et al. Nasal obstructive disorders induce medical treatment failure in paediatric persistent allergic rhinitis (The NODPAR Study). Pediatr Allergy Immunol 2017; 28: 176-184.
357
Dogru M, Evcimik MF, Calim OF. Does adenoid hypertrophy affect disease severity in children with allergic rhinitis? Eur Arch Otorhinolaryngol 2017; 274: 209-213.
358
Ameli F, Brocchetti F, Tosca MA, Signori A, Ciprandi G. Adenoidal hypertrophy and allergic rhinitis: is there an inverse relationship? Am J Rhinol Allergy 2013; 27: e5-10.
359
Nuhoglu C, Nuhoglu Y, Bankaoglu M, Ceran O.A retrospective analysis of adenoidal size in children. with allergic rhinitis and nonallergic idiopathic rhinitis. Asian Pac J Allergy Immunol 2010; 28: 136-40.
360
Bozkurt G, Dizdar SK, Korkut AY, Coşkun BU. Adenoid Vegetation in Children with Allergic Rhinitis. Turk Arch Otorhinolaryngol 2015; 53: 168-72.
361
Hellings PW, Fokkens WJ. Allergic rhinitis and its impact on otorhinolaryngology. Allergy 2006; 61: 656-64.
362
Vinke JG, KleinJan A, Severijnen LW, Hoeve LJ, Fokkens WJ. Differences in nasal cellular infiltrates between allergic children and age-matched controls. Eur Respir J 1999; 13: 797-803.
363
Nguyen LH, Manoukian JJ, Sobol SE, Tewfik TL, Mazer BD, Schloss MD, et al. Similar allergic inflammation in the middle ear and the upper airway: evidence linking otitis media with effusion to the united airways concept. J Allergy Clin Immunol 2004; 114: 1110-5.
364
Alaygut D,Ünlü M,Sutay S,Karaman Ö, Anal Ö. Adenoidal tissue expression of CD23 (FceRII): An evaluation with reference to recurrent upper respiratory tract complaints and allergy in children. Journal of Clinical and Experimental Investigations 2013; 4 : 1-7.
365
Chohan A, Lal A, Chohan K, Chakravarti A, Gomber S. Systematic review and meta-analysis of randomized controlled trials on the role of mometasone in adenoid hypertrophy in children. Int J Pediatr Otorhinolaryngol 2015; 79: 1599-608.
366
Chadha NK, Zhang L, Mendoza-Sassi RA, César JA. Using nasal steroids to treat nasal obstruction caused by adenoid hypertrophy: does it work? Otolaryngol Head Neck Surg 2009; 140: 139-47.
367
Tatar M, Plevkova J, Brozmanova M, Pecova R, Kollarik M. Mechanisms of the cough associated with rhinosinusitis. Pulm Pharmacol Ther 2009; 22: 121-6.
368
Pecova R, Vrlic M, Tatar M. Cough sensitivity in allergic rhinitis. J Physiol Pharmacol 2005; 56: 171-8.
369
Pecova R, Zucha J, Pec M, Neuschlova M, Hanzel P, Tatar M. Cough reflex sensivity testing in seasonal allergic rhinitis patients and healthy volunteers. J Physiol Pharmacol 2008; 59: 557-64.
370
Krouse JH, Altman KW. Rhinogenic laryngitis, cough, and the unified airway. Otolaryngol Clin North Am 2010; 43: 111-21.
371
Hadley AJ, Derebery MJ, Marple BF. Comorbidities and allergic rhinitis: not just a runny nose. J Fam Pract 2012; 61: S11-5.
372
Olze H, Zuberbier T. Comorbidities between nose and skin allergy. Curr Opin Allergy Clin Immunol 2011; 11: 457-63.
373
Pols DHS, Bohnen AM, Nielen MMJ, Korevaar JC, Bindels PJE. Risks for comorbidity in children with atopic disorders. An observational study in Dutch general practices. BMJ Open 2017; 12: e018091.
374
Mullol J, Maurer M, Bousquet J. Sleep and allergic rhinitis. J Investig Allergol Clin Immunol 2008; 18: 415-9.
375
Ferguson B. Influences of allergic rhinitis on sleep. Otolaryngol Head Neck Surg 2004; 130: 617-29.
376
Shedden A. Impact of nasal congestion on quality of life and work productivity in allergic rhinitis: Findings from a large online survey. Treat Respir Med 2005; 4: 439-46
377
Craig TJ, Sherkat A, Safaee S. Congestion and sleep-impairment in allergic rhinitis. Curr Allergy Asthma Rep 2010; 10: 113-21.
378
Gonzalez-Nunez V, Valero AL, Mullol J. Impact of sleep as a specific marker of quality of life in allergic rhinitis. Curr Allergy Asthma Rep 2013; 13: 131-41.
379
Leger D, Annesi-Maesano I, Carat F, Rugina M, Chanal I, Pribil C et al. Allergic rhinitis and its consequences on quality of sleep: an unexplored area. Arch Intern Med 2006; 166: 1744-8.
380
Colas C, Galera H, Anibarro B, Soler R, Navarro A, Jauregui I et al. Disease severity impairs sleep quality in allergic rhinitis. Clin Exp Allergy 2012; 42: 1080-7.
381
Lin SY, Melvin TA, Boss EF, Iscman SL. The association between allergic rhinitis and sleep-disordered breathing in children: a systematic review. Int Forum 2013; 3: 504-9.
382
Kalra M, Lemasters G, Bernstein D, Wilson K, Levin L, Cohen A et al. Atopy as a risk factor for habitual snoring at age 1 year. Chest 2006; 129: 942-6.
383
Chng SY, Goh DY, Wang XS, Tan TN, Ong NB. Snoring and atopic disease: a strong association. Pediatr Pulmonol 2004; 38: 210-6.
384
Bunn WB, Pikelny DB, Paralkar S, Slavin T, Borden S, Allen HM. The burden of allergies--and the capacity of medications to reduce this burden-in a heavy manufacturing environment. J Occup Environ Med 2003; 45: 941-55.
385
Benninger MS, Benninger RM. The impact of allergic rhinitis on sexual activity, sleep, and fatigue. Allergy Asthma Proc 2009; 30: 358-65.
386
Kirmaz C, Aydemir O, Bayrak P, Yüksel H, Ozenturk O, Degirmenci S. Sexual dysfunction in patients with allergic rhinoconjunctivities. Ann Allergy Asthma Immunol 2005; 95: 525-9.
387
Ahluwalia SK, Matsui EC. Indoor Environmental Interventions for Furry Pet Allergens, Pest Allergens, and Mold: Looking to the Future. The journal of allergy and clinical immunology In practice 2018; 6: 9-19.
388
Portnoy J, Kennedy K, Sublett J, Phipatanakul W, Matsui E, Barnes C, et al. Environmental assessment and exposure control: a practice parameter--furry animals. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2012; 108: 223 e1-15.
389
Wise SK, Lin SY, Toskala E, Orlandi RR, Akdis CA, Alt JA, et al. International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis. International forum of allergy & rhinology. 2018; 8: 108-352.
390
Matsui EC, Abramson SL, Sandel MT; SECTION ON ALLERGY AND IMMUNOLOGY; COUNCIL ON ENVIRONMENTAL HEALTH. Indoor Environmental Control Practices and Asthma Management. Pediatrics 2016; 138: e20162589.
391
Phipatanakul W, Matsui E, Portnoy J, Williams PB, Barnes C, Kennedy K, et al. Environmental assessment and exposure reduction of rodents: a practice parameter. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2012; 109: 375-87.
392
Sheehan WJ, Rangsithienchai PA, Wood RA, Rivard D, Chinratanapisit S, Perzanowski MS, et al. Pest and allergen exposure and abatement in inner-city asthma: a work group report of the American Academy of Allergy, Asthma & Immunology Indoor Allergy/Air Pollution Committee. The Journal of allergy and clinical immunology 2010; 125: 575-81.
393
Rabito FA, Carlson JC, He H, Werthmann D, Schal C. A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children. The Journal of allergy and clinical immunology 2017; 140: 565-70.
394
Portnoy J, Miller JD, Williams PB, Chew GL, Zaitoun F, Phipatanakul W, et al. Environmental assessment and exposure control of dust mites: a practice parameter. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2013; 111: 465-507.
395
Nurmatov U, van Schayck CP, Hurwitz B, Sheikh A. House dust mite avoidance measures for perennial allergic rhinitis: an updated Cochrane systematic review. Allergy. 2012; 67: 158-65.
396
Sheikh A, Hurwitz B, Nurmatov U, van Schayck CP. House dust mite avoidance measures for perennial allergic rhinitis. Cochrane Database Syst Rev 2010; 2010: CD001563.
397
Arroyave WD, Rabito FA, Carlson JC, Friedman EE, Stinebaugh SJ. Impermeable dust mite covers in the primary and tertiary prevention of allergic disease: a meta-analysis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2014; 112: 237-48.
398
Leas BF, D’Anci KE, Apter AJ, Bryant-Stephens T, Lynch MP, Kaczmarek JL, et al. Effectiveness of indoor allergen reduction in asthma management: A systematic review. J Allergy Clin Immunol 2018; 141: 1854-69.
399
Jaakkola MS, Quansah R, Hugg TT, Heikkinen SA, Jaakkola JJ. Association of indoor dampness and molds with rhinitis risk: a systematic review and meta-analysis. The Journal of allergy and clinical immunology 2013; 132: 1099-110.
400
Baxi SN, Portnoy JM, Larenas-Linnemann D, Phipatanakul W. Exposure and Health Effects of Fungi on Humans. The journal of allergy and clinical immunology In practice 2016; 4: 396-404.
401
Sauni R, Verbeek JH, Uitti J, Jauhiainen M, Kreiss K, Sigsgaard T. Remediating buildings damaged by dampness and mould for preventing or reducing respiratory tract symptoms, infections and asthma. Cochrane Database Syst Rev 2015; 2015: CD007897.
402
Park JH, Cho SJ, White SK, Cox-Ganser JM. Changes in respiratory and non-respiratory symptoms in occupants of a large office building over a period of moisture damage remediation attempts. PloS one 2018; 13: e0191165.
403
Le Cann P, Paulus H, Glorennec P, Le Bot B, Frain S, Gangneux JP. Home Environmental Interventions for the Prevention or Control of Allergic and Respiratory Diseases: What Really Works. The journal of allergy and clinical immunology In practice 2017; 5: 66-79.
404
Baxi SN, Phipatanakul W. The role of allergen exposure and avoidance in asthma. Adolescent medicine: state of the art reviews 2010; 21: 57-71.
405
Reisacher WR. Allergy treatment: environmental control strategies. Otolaryngologic clinics of North America 2011; 44: 711-25.
406
Mims JW, Biddy AC. Efficacy of environmental controls for inhalant allergies. Current opinion in otolaryngology & head and neck surgery 2013; 21: 241-7.
407
Smith M, Cecchi L, Skjoth CA, Karrer G, Sikoparija B. Common ragweed: a threat to environmental health in Europe. Environment international 2013; 61: 115-26.
408
Borchers AT, Chang C, Eric Gershwin M. Mold and Human Health: a Reality Check. Clinical reviews in allergy & immunology 2017; 52: 305-22.
409
Singh M, Hays A. Indoor and Outdoor Allergies. Primary care 2016; 43: 451-63.
410
Bastl K, Berger U, Kmenta M. Evaluation of Pollen Apps Forecasts: The Need for Quality Control in an eHealth Service. Journal of medical Internet research 2017; 19: e152.
411
Wandalsen GF, Miranda C, Ensina LF, Sano F, Amazonas RB, Silva JMD, et al. Association between desloratadine and prednisolone in the treatment of children with acute symptoms of allergic rhinitis: a double-blind, randomized and controlled clinical trial. Braz J Otorhinolaryngol 2017; 83: 633-639.
412
Karatzanis A, Chatzidakis A, Milioni A, Vlaminck S, Kawauchi H, Velegrakis S, et al. Contemporary Use of Corticosteroids in Rhinology. Curr Allergy Asthma Rep 2017; 17: 11.
413
Aasbjerg K, Torp-Pedersen C, Backer V. Specific immunotherapy can greatly reduce the need for systemic steroids in allergic rhinitis. Allergy 2012; 67(: 1423-9.
414
Aasbjerg K, Torp-Pedersen C, Vaag A, Backer V. Treating allergic rhinitis with depot-steroid injections increase risk of osteoporosis and diabetes. Respir Med 2013; 107: 1852-8.
415
Lipworth B, Newton J, Ram B, Small I, Schwarze J. An algorithm recommendation for the pharmacological management of allergic rhinitis in the UK: a consensus statement from an expert panel. NPJ Prim Care Respir Med 2017; 27: 3.
416
Aadal M, Slørdal L. Glucocorticoid injections in the treatment of seasonal allergies Tidsskr Nor Laegeforen 2014; 134: 186-8.
417
Brożek JL, Bousquet J, Agache I, Agarwal A, Bachert C, Bosnic-Anticevich S. Allergic Rhinitis and its Impact on Asthma (ARIA) Guideline-2016 revision. J Allergy Clin Immunol 2017; 140: 950-8.
418
Karaki M, Akiyama K, Mori N. Efficacy of intranasal steroid spray (mometasone furoate) on treatment of patients with seasonal allergic rhinitis: comparison with oral corticosteroids. Auris Nasus Larynx 2013; 40: 277-81.
419
Jang TY, Kim YH. Recent Updates on the Systemic and Local Safety of Intranasal Steroids. Curr Drug Metab 2016; 17: 992-6.
420
Gupta R, Fonacier LS. Adverse Effects of Nonsystemic Steroids (Inhaled, Intranasal, and Cutaneous): a Review of the Literature and Suggested Monitoring Tool. Curr Allergy Asthma Rep 2016; 16: 44.
421
Verkerk MM, Bhatia D, Rimmer J, Earls P, Sacks R, Harvey RJ. Intranasal steroids and the myth of mucosal atrophy: a systematic review of original histological assessments. Am J Rhinol Allergy 2015; 29: 3-18.
422
Schleimer RP. An overview of glucocorticoid anti-inflammatory actions. Eur JClin Pharmacol 1993; 45 Suppl 1: S3-7.
423
Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, et al. Clinical practice guideline: allergic rhinitis. Otolaryngol Head Neck Surg 2015; 152: S1-43.
424
Ezerarslan H. Allergic rhinitis and corticosteroid resistance. Turkish J Rhinology. 2015; 4: 56-64.
425
Rachelefsky G, Farrar JR. A control model to evaluate pharmacotherapy for allergic rhinitis in children. JAMA Pediatr 2013; 167: 380-6.
426
Develioglu ON, Paltura C, Koleli H, Kulekci M. The effect of medical treatment on voice quality in allergic rhinitis. Indian J Otolaryngol Head Neck Surg 2013; 65: 426-30.
427
Sher ER, Ross JA. Intranasal corticosteroids: the role of patient preference and satisfaction. Allergy Asthma Proc 2014; 35: 24-33.
428
Wang X, Zhu Y, Ni D, Lv W, Gao Z, Qi F. Intranasal application of glucocorticoid alleviates olfactory dysfunction in mice with allergic rhinitis. Exp Ther Med 2017; 14: 3971-8.
429
Dalgic A, Dinc ME, Ulusoy S, Dizdar D, Is A, Topak M. Comparison of the effects of nasal steroids and montelukast on olfactory functions in patients with allergic rhinitis. Eur Ann Otorhinolaryngol Head Neck Dis 2017; 134: 213-6.
430
Özdemir O, Elmas B. Correlation between prevalence of allergic rhinitis and certain diseases. MOJ Immunol 2015; 2: 00042.
431
Hoyte FC, Meltzer EO, Ostrom NK, Nelson HS, Bensch GW, Spangler DL, et al. Recommendations for the pharmacologic management of allergic rhinitis. Allergy Asthma Proc 2014; 35: S20-7.
432
Khan DA. Allergic rhinitis and asthma: epidemiology and common pathophysiology. Allergy Asthma Proc 2014; 35: 357-61.
433
Bozkurt G, Kurt Dizdar S, Korkut AY, Coşkun BU. Adenoid vegetation in children with allergic rhinitis. Turk Arch Otorhinolaryngol 2015; 53: 168-72.
434
Yasar M, Uysal OI, Altuntaş EE, Cevit O, Müderris S. Effects of topical sprays on allergy-induced nasal obstruction in children. Kulak Burun Bogaz Ihtis Derg 2013; 23: 217-24.
435
Liu W, Zhou L, Zeng Q, Luo R. Combination of mometasone furoate and oxymetazoline for the treatment of adenoid hypertrophy concomitant with allergic rhinitis: A randomized controlled trial. Sci Rep 2017; 7: 404-25.
436
Durham SR, Creticos PS, Nelson HS, Li Z, Kaur A, Meltzer EO, Nolte H. Treatment effect of sublingual immunotherapy tablets and pharmacotherapies for seasonal and perennial allergic rhinitis: Pooled analyses. J Allergy Clin Immunol 2016; 138: 1081-1088.e4.
437
Carr WW. New therapeutic options for allergic rhinitis: back to the future with intranasal corticosteroid aerosols. Am J Rhinol Allergy 2013; 27: 309-13.
438
Aneeza WH, Husain S, Rahman RA, Van Dort D, Abdullah A, Gendeh BS. Efficacy of mometasone furoate and fluticasone furoate on persistent allergic rhinoconjunctivitis. Allergy Rhinol (Providence) 2013; 4: e120-6.
439
Yanez A, Dimitroff A, Bremner P, Rhee CS, Luscombe G, Prillaman BA, Johnson N. A patient preference study that evaluated fluticasone furoate and mometasone furoate nasal sprays for allergic rhinitis. Allergy Rhinol (Providence) 2016; 7: 183-92.
440
Yonezaki M, Akiyama K, Karaki M, Goto R, Inamoto R, Samukawa Y, Kobayashi R, Kobayashi E, Hoshikawa H. Preference evaluation and perceived sensory comparison of fluticasone furoate and mometasone furoate intranasal sprays in allergic rhinitis. Auris Nasus Larynx 2016; 43: 292-7.
441
Bensch GW. Safety of intranasal corticosteroids. Ann Allergy Asthma Immunol 2016; 117: 601-5.
442
Trybus E, Krol T, Obarzanowski T, Trybus W, Kopacz-Bednarska A, Obarzanowski M. Cytological assessment of the epithelial cells of the nasal mucous membrane after local fluticasone therapy. J Physiol Pharmacol 2015; 66: 139-47.
443
Elbay A , Yenigün A , Özdemir H , Çalım Ö , Ekinci C, Çetinkaya R . Does the use of corticosteroid nasal spray play a role in the development of central serous chorioretinopathy?. Anadolu Klin 2017; 22: 163-8.
444
Şimşek A, Bayraktar C, Doğan S, Karataş M, Sarıkaya Y. The effect of long-term use of intranasal steroids on intraocular pressure. Clin Ophthalmol 2016; 10: 1079-82.
445
Lee LA, Sterling R, Máspero J, Clements D, Ellsworth A, Pedersen S. Growth velocity reduced with once-daily fluticasone furoate nasal spray in prepubescent children with perennial allergic rhinitis. J Allergy Clin Immunol Pract 2014; 2: 421-7.
446
Mener DJ, Shargorodsky J, Varadhan R, Lin SY. Topical intranasal corticosteroids and growth velocity in children: a meta-analysis. Int Forum Allergy Rhinol 2015; 5: 95-103.
447
Özdemir Ö, Elmas B. New Developments in the Diagnosis and Therapy of Allergic Rhinitis. Asthma Allergy Immunol 2016; 14: 1-16.
448
Mansfield LE, Mendoza CP. Medium and long-term growth in children receiving intranasal beclomethasone dipropionate: a clinical experience. South Med J 2002; 95: 334-40.
449
Hampel FC Jr, Nayak NA, Segall N, Small CJ, Li J, No hypothalamic-pituitary-adrenal function effect with beclomethasone dipropionate nasal aerosol, based on 24-hour serum cortisol in pediatric allergic rhinitis. Tantry SK4.Ann Allergy Asthma Immunol 2015; 115: 137-42.
450
Georges G, Kim KT, Ratner P, Segall N, Qiu C. Effect of intranasal triamcinolone acetonide on basal hypothalamic- pituitary-adrenal axis function in children with allergic rhinitis. Allergy Asthma Proc 2014; 35: 163-70.
451
Rodríguez-Martínez CE, Sossa-Briceño MP, Vladimir Lemos E. Cost-effectiveness analysis of mometasone furoate versus beclomethasone dipropionate for the treatment of pediatric allergic rhinitis in Colombia. Adv Ther 2015; 32: 254-69.
452
Martino BJ, Church CA, Seiberling KA. Effect of intranasal dexamethasone on endogenous cortisol level and intraocular pressure. Int Forum Allergy Rhinol 2015; 5: 605-9.
453
Raphael GD, Berger WE, Prenner BM, Finn AF Jr, Kelley L, Tantry SK. Efficacy, safety, and optimal dose selection of beclomethasone dipropionate nasal aerosol for seasonal allergic rhinitis in adolescents and adults. Curr Med Res Opin 2013; 29: 1329-40.
454
Storms WW, Segall N, Mansfield LE, Amar NJ, Kelley L, Ding Y, et al. Efficacy and safety of beclomethasone dipropionate nasal aerosol in pediatric patients with seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2013; 111: 408-414.e1.
455
Sonnemann U, Möller M, Bilstein A. Noninterventional open-label trial investigating the efficacy and safety of ectoine containing nasal spray in comparison with beclomethasone nasal spray in patients with allergic rhinitis. J Allergy (Cairo) 2014;2 014: 297203.
456
Weinstein SF, Andrews CP, Shah SR, Chylack LT Jr, Tankelevich A, Ding Y, et al. Long-term efficacy and safety of once-daily treatment with beclomethasone dipropionate nasal aerosol. Allergy Asthma Proc 2014; 35: 323-31.
457
Berger WE, Meltzer EO. Intranasal spray medications for maintenance therapy of allergic rhinitis. Am J Rhinol Allergy 2015; 29: 273-82.
458
Mansfield LE. Beclomethasone HFA for the treatment of allergic rhinitis. Expert Opin Pharmacother. 2015; 16: 2849-57.
459
Ferrante G, Montalbano L, Cilluffo G, Malizia V, Marchese D, La Grutta S. Beclomethasone dipropionate hydrofluoroalkane for the treatment of allergic rhinitis. Expert Rev Clin Immunol 2016; 12: 279-88.
460
Bukstein D, Parikh R, Eid S, Ferro T, Morello JP. Beclomethasone Dipropionate Nasal Aerosol in Patients with Perennial Allergic Rhinitis(BALANCE) study: 6-month results. Allergy Asthma Proc 2016; 37: 121-30.
461
Brown K, Lane J, Silva MP, DeTineo M, Naclerio RM, Baroody FM. A pilot study of the effects of intranasal budesonide delivered by NasoNeb® on patients with perennial allergic rhinitis. Int Forum Allergy Rhinol 2014; 4: 43-8.
462
Zicari AM, Occasi F, Montanari G, Indinnimeo L, De Castro G, Tancredi G, et al. Intranasal budesonide in children affected by persistent allergic rhinitis and its effect on nasal patency and Nasal Obstruction Symptom Evaluation (NOSE) score. Curr Med Res Opin 2015; 31: 391-6.
463
Li Z, Geng M. [Effect of budesonide on the expression of IL-12 in animal model of minimal persistent inflammation of allergic rhinitis in rats]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2015; 29: 270-4.
464
Meltzer EO, Bensch GW, Storms WW. New intranasal formulations for the treatment of allergic rhinitis. Allergy Asthma Proc 2014; 35: S11-9.
465
Emanuel IA, Blaiss MS, Meltzer EO, Evans P, Connor A. Nasal deposition of ciclesonide nasal aerosol and mometasone aqueous nasal spray in allergic rhinitis patients. Am J Rhinol Allergy 2014; 28: 117-21.
466
Berger WE, Prenner B, Turner R, Meltzer EO. A patient preference and satisfaction study of ciclesonide nasal aerosol and mometasone furoateaqueous nasal spray in patients with perennial allergic rhinitis. Allergy Asthma Proc 2013; 34: 542-50.
467
Wu W1, Walters RD, Nadeau GA, Botnick W, Broughton N. An integrated analysis of the efficacy of fluticasone furoate nasal spray versus placebo on the nasal symptoms of perennial allergic rhinitis. Allergy Asthma Proc 2013; 34: 283-91.
468
Okubo K, Okamasa A, Honma G, Komatsubara M. Efficacy and safety of fluticasone furoate nasal spray in Japanese children with perennial allergic rhinitis: a multicentre, randomized, double-blind, placebo-controlled trial. Allergol Int 2014; 63: 543-51.
469
Okubo K, Okamasa A, Honma G, Komatsubara M. Safety and efficacy of fluticasone furoate nasal spray in Japanese children 2 to <15 years of age with perennial allergic rhinitis: a multicentre, open-label trial. Allergol Int 2015; 64: 60-5.
470
Špadijer Mirković C, Perić A, Vukomanović Đurđević B, Vojvodić D. Effects of Fluticasone Furoate Nasal Spray on Parameters of Eosinophilic Inflammation in Patients With Nasal Polyposis and Perennial Allergic Rhinitis. Ann Otol Rhinol Laryngol 2017; 126: 573-80.
471
Ratner P, Van Bavel J, Mohar D, Jacobs RL, Hampel F, Howland W, Karwal R. Efficacy of daily intranasal fluticasone propionate on ocular symptoms associated with seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2015; 114: 141-7.
472
Ford LB, Matz J, Hankinson T, Prillaman B, Georges G. A comparison of fluticasone propionate nasal spray and cetirizine in ragweed fall seasonal allergic rhinitis. Allergy Asthma Proc 2015; 36: 313-9.
473
Jindal A, Suriyan S, Sagadevan S, Narasimhan M, Shanmuganathan A, Vallabhaneni V, et al. Comparison of Oral Montelukast and Intranasal Fluticasone in Patients with Asthma and Allergic Rhinitis. J Clin Diagn Res 2016; 10: OC06-10.
474
Muganurmath CS, Curry AL, Schindzielorz AH. Causality Assessment of Olfactory and Gustatory Dysfunction Associated with Intranasal Fluticasone Propionate: Application of the Bradford Hill Criteria. Adv Ther 2018; 35: 173-90.
475
Baccioglu Kavut A, Kalpaklıoğlu F. Efficacy and safety of once daily triamcinolone acetonide aqueous nasal spray in adults with non-allergic and allergic rhinitis. Allergol Immunopathol (Madr) 2013; 41: 374-80.
476
Schenkel E, Newman KB. Therapeutic equivalence of triamcinolone acetonide hydrofluoroalkane and chlorofluorocarbon nasal inhalers in patients with seasonal allergic rhinitis. Am J Rhinol Allergy 2013; 27: 109-12.
477
Mak KK, Ku MS, Lu KH, Sun HL, Lue KH. Comparison of mometasone furoate monohydrate (Nasonex) and fluticasone propionate (Flixonase) nasal sprays in the treatment of dust mite-sensitive children with perennial allergic rhinitis. Pediatr Neonatol 2013; 54: 239-45.
478
Meltzer EO, Baena-Cagnani CE, Gates D, Teper A. Relieving nasal congestion in children with seasonal and perennial allergic rhinitis: efficacy and safety studies of mometasone furoate nasal spray. World Allergy Organ J 2013; 6: 5.
479
Kujundzić M, Babarović E, Petković M, Pavlović-Ruzić I, Coklo M, Zamolo G. Mometasone furoate and nasal vascularisation in allergic patients. Coll Antropol 2013; 37: 127-30.
480
Kuna P, Wasiak W, Jones S, Kreft KZ. Comparative safety and efficacy of two formulations of mometasone nasal spray in adult seasonal allergic rhinitis. Allergy Asthma Proc 2014; 35: 332-7.
481
Passali D, Spinosi MC, Crisanti A, Bellussi LM. Mometasone furoate nasal spray: a systematic review. Multidiscip Respir Med 2016; 11: 18.
482
Antila MA, Castro FM, Sano F, Machado A, Fernandes F, Rosário Filho NA,et al. Mometasone furoate in the treatment of mild, moderate, or severe persistent allergic rhinitis: a non-inferiority study (PUMA). Braz J Otorhinolaryngol 2016; 82: 580-8.
483
Samoliński B, Nowicka A, Wojas O, Lipiec A, Krzych-Fałta E, Tomaszewska A. Intranasal glucocorticosteroids - not only in allergic rhinitis In the 40th anniversary of intranasal glucocorticosteroids’ introduction. Otolaryngol Pol 2014; 68: 51-64.
484
Daley-Yates PT, Price AC, Sisson JR, Pereira A, Dallow N. Beclomethasone dipropionate: absolute bioavailability, pharmacokinetics and metabolism following intravenous, oral, intranasal and inhaled administration in man. Br J Clin Pharmacol 2001; 51: 400-9.
485
Rapiejko P, Sosnowski TR, Sova J, Jurkiewicz D. Deposition of intranasal glucocorticoids--preliminary study. Otolaryngol Pol 2015; 69: 30-8.
486
Alhussien AH, Alhedaithy RA, Alsaleh SA. Safety of intranasal corticosteroid sprays during pregnancy: an updated review. Eur Arch Otorhinolaryngol 2018; 275: 325-33.
487
Leach CL, Kuehl PJ, Chand R, McDonald JD. Nasal Deposition of HFA-Beclomethasone, Aqueous Fluticasone Propionate and Aqueous Mometasone Furoate in Allergic Rhinitis Patients. J Aerosol Med Pulm Drug Deliv 2015; 28: 334-40.
488
Ganesh V, Banigo A, MucMurran AEL, Shakeel M, Ram B. Does intranasal steroid spray technique affect side effects and compliance? Results of a patient survey. J Laryngol Otol 2017; 131: 991-996.
489
Ecevit MC. Allerjik Rinitte Medikal Tedavi. Turkiye Klinikleri Journal of Ear Nose and Throat-Special Topics 2015; 8: 43-8.
490
Koca Kalkan I, Baccioglu Kavut A, Kalpaklioglu AF. Allergic rhinitis: can we identify nonadherence to therapy and its predictors easily in daily practice? J Investig Allergol Clin Immunol 2013; 23: 315-22.
491
Ocak E, Kocaoz D, Acar B. How can we improve medical adherence to intranasal corticosteroids in children? Int J Pediatr Otorhinolaryngol 2017; 100: 194-197.
492
May JR, Dolen WK. Management of Allergic Rhinitis: A Review for the Community Pharmacist. Clin Ther 2017; 39: 2410-19.
493
Kuna P, Jurkiewicz D, Czarnecka-Operacz MM, Pawliczak R, Woroń J, Moniuszko M, et al. The role and choice criteria of antihistamines in allergy management - expert opinion. Postepy Dermatol Alergol 2016; 33: 397-410.
494
Seidman MD, Gurgel RK, Lin SY, Schwartz SR, Baroody FM, Bonner JR, et al. Clinical practice guideline: allergic rhinitis executive summary. Otolaryngol Head Neck Surg 2015; 152: 197-206.
495
Klimek L, Mullol J, Hellings P, Gevaert P, Mösges R, Fokkens W. Recent pharmacological developments in the treatment of perennial and persistent allergic rhinitis. Expert Opin Pharmacother 2016; 17: 657-69.
496
Hu Y, Sieck DE, Hsu WH. Why are second-generation H1-antihistamines minimally sedating? Eur J Pharmacol 2015; 765: 100-6.
497
Anagnostou K, Swan KE, Brough H . The use of antihistamines in children. Paediatrics and Child Health 2016; 26: 310-3.
498
Leceta A, Sologuren A, Valiente R, Campo C, Labeaga L. Bilastine in allergic rhinoconjunctivitis and urticaria: a practical approach to treatment decisions based on queries received by the medical information department. Drugs Context 2017; 6: 212500.
499
Valk PJ, Van Roon DB, Simons RM, Rikken G. Desloratadine shows no effect on performance during 6 h at 8,000 ft simulated cabin altitude. Aviat Space Environ Med 2004; 75: 433-8.
500
Skoner DP, LaForce CF, Nathan RA, Urdaneta ER, Zielinski MA, Sacavage SD, Franklin KB, Wu MM. Effect of cetirizine on symptom severity and quality of life in perennial allergic rhinitis. Allergy Asthma Proc 2014; 35: 338-45.
501
Mösges R, König V, Köberlein J. The effectiveness of modern antihistamines for treatment of allergic rhinitis - an IPD meta-analysis of 140,853 patients. Allergol Int 2013; 62: 215-22.
502
Poluzzi E, Diemberger I, De Ridder M, Koci A, Clo M, Oteri A, at al. Use of antihistamines and risk of ventricular tachyarrhythmia: a nested case-control study in five European countries from the ARITMO project. Eur J Clin Pharmacol 2017; 73: 1499-510.
503
Pecoraro L, Paiola G, Pietrobelli A. Ebastine overdose in a child. Clin Case Rep 2017; 5: 403-5.
504
Bousquet J, Ansótegui I, Canonica GW, Zuberbier T, Baena-Cagnani CE, Bachert C, et al. Establishing the place in therapy of bilastine in the treatment of allergic rhinitis according to ARIA: evidence review. Curr Med Res Opin 2012; 28: 131-9.
505
Anna Olasińska-Wiśniewska, Jerzy Olasiński, Stefan Grajek .Cardiovascular safety of antihistamines. Postep Derm Alergol 2014; 3: 182-6.
506
Mullol J, Bousquet J, Bachert C, Canonica GW, Giménez-Arnau A, Kowalski ML, et al. Update on rupatadine in the management of allergic disorders. Allergy 2015; 70: 1-24.
507
Munoz-Cano R, Ainsua-Enrich E, Torres-Atencio I, Martin M, Sánchez-Lopez J, Bartra J,et al. A. Effects of Rupatadine on Platelet- Activating Factor-Induced Human Mast Cell Degranulation Compared With Desloratadine and Levocetirizine (The MASPAF Study). J Investig Allergol Clin Immunol 2017; 27: 161-8.
508
Keam SJ1, Plosker GL. Rupatadine: a review of its use in the management of allergic disorders. Drugs 2007; 67: 457-74.
509
Dávila I, del Cuvillo A, Mullol J, Jáuregui I, Bartra J, Ferrer M, et al. Use of second generation H1 antihistamines in special situations. J Investig Allergol Clin Immunol 2013; 23: 1-16.
510
Endo S, Yamamoto Y, Minami Y, Okumura S, Sasaki T, Ohsaki Y. Histamine H1 antagonist levocetirizine as a potential cause of lung injury. Respirol Case Rep 2015; 3: 64-7.
511
Guillermina E, Budiño D. Evaluation of caridotoxicity of rupatadine, and antihistamine, as recommendeded by ICH E14. Universitat Autònoma de Barcelona, Doctoral Thesis. 2016. Esther 2016.
512
Church MK. Safety and efficacy of bilastine: a new H(1)-antihistamine for the treatment of allergic rhinoconjunctivitis and urticaria. Expert Opin Drug Saf 2011; 10: 779-93.
513
Kuna P, Bachert C, Nowacki Z, van Cauwenberge P, Agache I, Fouquert L, at al; Bilastine International Working Group. Efficacy and safety of bilastine 20 mg compared with cetirizine 10 mg and placebo for the symptomatic treatment of seasonal allergic rhinitis: a randomized, double-blind, parallel-group study. Clin Exp Allergy 2009; 39: 1338-47.
514
Jung MC, Kim JK, Cho JY, Song JW, Lee B, Park JW, et al. A case of levocetirizine-induced liver injury. Clin Mol Hepatol 2016; 22: 495-8.
515
Kim MY, Jo EJ, Chang YS, Cho SH, Min KU, Kim SH. A case of levocetirizine-induced fixed drug eruption and cross-reaction with piperazine derivatives. Asia Pac Allergy 2013 ; 3: 281-4.
516
Johnson M1, Kwatra G1, Badyal DK1, Thomas EA2. Levocetirizine and rupatadine in chronic idiopathic urticaria. Int J Dermatol. 2015; 54: 1199-204.
517
Lieberman P. Intranasal antihistamines for allergic rhinitis: mechanism of action. Allergy Asthma Proc 2009; 30: 345- 8.
518
Broide DH. Pathophysiology of allergic rhinitis. Allergy Asthma Proc 2007; 28: 398-403.
519
Yamauchi Y, Fujikura T, Shimosawa T. The effect of H1 antagonists carebastine and olopatadine on histamine nduced expression of CC chemokines in cultured human nasal epithelial cells. AllergolInt 2007; 56: 171-7.
520
Kishimoto K, Kaneko S, Ohmori K, et al. Olopatadine suppresses themigration of THP-1 monocytesinducedby S100A12 protein. Mediators Inflamm 2006; 2006: 42726.
521
Rosenwasser L. New insightsintothepathophysiology of allergic rhinitis. Allergy Asthma Proc 2007; 28: 10-5.
522
Sarin S, Undem B, Sanico A, et al. The role of the nervous system in rhinitis. J Allergy ClinImmunol 2006; 118: 999-1016.
523
Chalastras T, Nicolopoulou-Stamati P, Patsouris E, Eleftheriadou A, Kandiloros D, Yiotakis I, et al. Expression of substance P, vasoactive intestinal peptide and heat shock protein 70 in nasal mucosal smears of patients with allergic rhinitis: investigation using a liquid-based method. J Laryngol Otol 2008; 122: 700-6.
524
Tamura T, Komai M. Effect of olopatadine hydrochloride, an anti-histamine drug, on rhinitis induced by intranasal instillation of toluene-2,4-diisocyanate in rats. Int Immunopharmacol 2008; 8: 916-21.
525
Sheahan P, Walsh RM, Walsh MA, et al. Hyperresponsiveness of congestivenasalreflexes in allergicrhinitis. Rhinology 2006; 44: 68-73.
526
Tang HB, Nakata Y. Olopatadine attenuates the enhancement of capsaicin-evoked substance P release by bradykinin from cultured dorsal root ganglion neurons. Eur J Pharmacol 2006; 552: 78-82.
527
Kaliner MA. Thetreatment of vasomotor nonallergicrhinitis. Clin Allergy Immunol 2007; 19: 351-62.
528
Astelin. Somerset, NJ: Med Pointe Pharmaceuticals Inc; 2007. Astelin 2007.
529
Astepro. Somerset, NJ: MedaPharmaceuticalsInc; 2009. Astelin 2009.
530
Bernstein JA. Azelastine hydrochloride: a review of pharmacology, pharmacokinetics, clinical efficacy and tolerability. Curr Med Res Opin 2007; 23: 2441-52.
531
Horak F, Zieglmayer UP, Zieglmayer R, Kavina A, Marschall K, Munzel U, et al. Azelastine nasal spray and desloratadine tablets in pollen-induced seasonal allergic rhinitis: a pharmacodynamic study of onset of action and efficacy. Curr Med Res Opin 2006; 22: 151-7.
532
Patel P, D’Andrea C, Sacks HJ. Onset of action of azelastine nasal spray compared with mometasone nasal spray and placebo in subjects with seasonal allergic rhinitis evaluated in an environmental exposure chamber. Am J Rhinol 2007; 21: 499-503.
533
Bernstein JA, Prenner B, Ferguson BJ, Portnoy J, Wheeler WJ, Sacks HJ. Double-blind, placebo-controlledtrial of reformulatedazelastinenasalspray in patients with seasonalallergicrhinitis. Am J Rhinol Allergy 2009; 23: 512-7.
534
vanBavel J, Howland WC, Amar NJ, Wheeler W, Sacks H. Efficacy and safety of azelastine 0.15% nasal spray administered once daily in subjects with seasonal allergic rhinitis. Allergy Asthma Proc 2009; 30: 512-8.
535
Pipkorn P, Costantini C, Reynolds C, et al. The effects of the nasal antihistamines olopatadine and azelastine in nasal allergen provocation. Ann Allergy Asthma Immunol 2008;101: 82-9.
536
Fairchild CJ, Meltzer EO, Roland PS, Wells D, Drake M, Wall GM. Comprehensivereport of theefficacy, safety, quality of life, andworkimpact of olopatadine 0.6% andolopatadine 0.4% treatment in patients with seasonal allergic rhinitis. Allergy Asthma Proc 2007; 28: 716-23.
537
Hampel FC Jr, Ratner PH, Amar NJ, et al. Improved quality of life among seasonal allergic rhinitis patients treated with olopatadine HCL nasalspray 0.4% and olopatadine HCl nasalspray 0.6% compared with vehicle placebo. Allergy Asthma Proc 2006; 27: 202-7.
538
Patel D, Garadi R, Brubaker M, Conroy JP, Kaji Y, Crenshaw K, Whitling A, Wall GM. Onset and duration of action of nasal sprays in seasonal allergic rhinitis patients: olopatadine hydrochloride versus mometasone furoate monohydrate. Allergy Asthma Proc 2007; 28: 592-9.
539
Patanase (olopatadinehydrochloride) 665 mcgNasalSpray. Fort Worth, TX: AlconLaboratories; 2009. PAtanase 2009.
540
Shah SR, Nayak A, Ratner P, Roland P, Michael Wall G. Effects of olopatadinehydrochloride nasal spray 0.6% in thetreatment of seasonal allergic rhinitis: a phase III, multicenter, randomized, double-blind, active- and placebo- controlled study in adolescents and adults. Clin Ther 2009; 31: 99 -107.
541
Berger WE, White MV; Rhinitis Study Group. Efficacy of azelastine nasal spray in patients with an unsatisfactory response to loratadine. Ann Allergy Asthma Immunol 2003; 91:2005-11.
542
LaForce CF, Corren J, Wheeler WJ, Berger WE; Rhinitis Study Group. Efficacy of azelastine nasal spray in seasonal allergic rhinitis patients who remain symptomatic after treatment with fexofenadine. Ann Allergy Asthma Immunol 2004; 93: 154-9.
543
Corren J, Storms WW, Bernstein J, et al. Effectiveness of azelastine nasal spray compared to oral cetirizine in patients with seasonal allergic rhinitis. ClinTher 2005; 27: 543-53.
544
Berger W, Hampel F Jr, Bernstein J, Shah S, Sacks H, Meltzer EO. Impact of azelastine nasal spray on symptoms and quality of life compared with cetirizine oral tablets in patients with seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2006; 97: 375-81.
545
Yanez A, Rodrigo GJ. Intranasal corticosteroids versus topical H1 receptor antagonists for the treatment of allergic rhinitis: a systematic review with meta-analysis. Ann Allergy Asthma Immunol. 2002; 89: 479-84.
546
Berger WE, Fineman SM, Lieberman P, Mile RM; RhinitisStudyGroups. Double-blindtrials of azelastine nasal spray monotherapy versus combination therapy with loratadine tablets and beclomethasone nasal spray in patients with seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 1999; 82: 535-41.
547
Kaliner MA, Storms W, Tilles S, Spector S, Tan R, LaForce C, et al. Comparison of olopatadine 0.6% nasal spray versus fluticasone propionate 50 microg in the treatment of seasonal allergic rhinitis. Allergy Asthma Proc 2009; 30: 255-62.
548
Ratner PH, Hampel F, Van Bavel J, Amar NJ, Daftary P, Wheeler W, Sacks H. Combination therapy with azelastine hydrochloride nasal spray and fluticasone propionate nasal spray in the treatment of patients with seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2008; 100: 74-81.
549
Barnes ML, Ward JH, Fardon TC, Lipworth BJ. Effects of levocetirizine as add-on therapy to fluticasone in seasonal allergic rhinitis. Clin Exp Allergy 2006; 36: 676-84.
550
Di Lorenzo G, Pacor ML, Pellitteri ME, Morici G, Di Gregoli A, Lo Bianco C, et al. Randomized placebo-controlled trial comparing fluticasone aqueous nasal spray in mono-therapy, fluticasone plus cetirizine, fluticasone plus montelukast and cetirizine plus montelukast for seasonal allergic rhinitis. Clin Exp Allergy 2004; 34: 259-67.
551
Kaliner MA. A novel and effective approach to treating rhinitis with nasal antihistamines. Ann Allergy Asthma Immunol 2007; 99: 383-92.
552
Cobanoğlu B, Toskala E, Ural A, Cingi C. Role of leukotriene antagonists and antihistamines in the treatment. Curr Allergy Asthma Rep 2013; 13: 203-8.
553
Peters-Golden M, Henderson WR Jr. The role of leukotrienes in allergic rhinitis. Ann Allergy Asthma Immunol 2005; 94: 609-18.
554
Ciebiada MG, Barylski M, Ciebiada M. Wheal and flare reactions in skin prick tests of patients treated with montelukast alone or in combination with antihistamines. Inflamm Res 2014; 63: 191-5.
555
Grainger J, Drake-Lee A. Montelukast in allergic rhinitis: a systematic review and metaanalysis. Clin Otolaryngol 2006; 31: 360-7.
556
Rodrigo GJ, Yanez A. The role of antileukotriene therapy in seasonal allergic rhinitis: A systematic review of randomized trials. Ann Allergy Asthma Immunol 2006; 96: 779-86.
557
Wilson AM, O’Byrne PM, Parameswaran K. Leukotriene receptor antagonists for allergic rhinitis: a systematic review and meta-analysis. Am J Med 2004; 116: 338-44.
558
Xu Y, Zhang J, Wang J. The efficacy and safety of selective H1-antihistamine versus leukotriene receptor antagonist for seasonal allergic rhinitis: a meta-analysis. PLoS One 2014; 9: e112815.
559
Philip G, Nayak AS, Berger WE, Leynadier F, Vrijens F, Dass SB, et al. The effect of montelukast on rhinitis symptoms in patients with asthma and seasonal allergic rhinitis. Curr Med Res Opin 2004; 20: 1549-58.
560
Rudmik L, Soler ZM. Medical Therapies for Adult Chronic Sinusitis: A Systematic Review. JAMA 2015; 314: 926-39.
561
Gane J, Buckley R. Leukotriene receptor antagonists in allergic eye disease: a systematic review and meta-analysis. J Allergy Clin Immunol Pract 2013; 1: 65-74.
562
Goh BS, Ismail MI, Husain S. Quality of life assessment in patients with moderate to severe allergic rhinitis treated with montelukast and/or intranasal steroids: a randomised, double-blind, placebo- controlled study. J Laryngol Otol 2014; 128: 242-8.
563
Hara H, Sugahara K, Hashimoto M, Mikuriya T, Tahara S, Yamashita H. Effectiveness of the leukotriene receptor antagonist pranlukast hydrate for the treatment of sleep disorder in patients with perennial allergic rhinitis. Acta Otolaryngol 2014; 134: 307-13.
564
Erdoğan BA, Sanlı A, Paksoy M, Altın G, Aydın S. Quality of life in patients with persistent allergic rhinitis treated with desloratadine monotherapy or desloratadine plus montelucast combination. Kulak Burun Bogaz Ihtis Derg 2014; 24: 217-24.
565
Yarıktaş M, Ünlü M, Döner F, Şahin Ü. Comparison of leukotriene receptor rntagonist and antihistamine therapy in seasonal allergic rhinitis. Türk Otolarengoloji Arşivi 2002; 40: 252-6.
566
Karabıçak H. Alerjik rinitli hastalarda flutikazon propiyonatın tek başına, levosetrizin veya montelukast ile birlikte kullanımlarının tedavi üzerine etkinliklerinin karşılaştırılması. Kırıkkale Üniversitesi Tıp Fakültesi Kulak, Burun ve Boğaz Hastalıkları Anabilim Dalı, Tıpta Uzmanlık Tezi, 2011.
567
Bozkurt MK, Tülek B, Akyürek N, Öz M, Kıyıcı A. Comparison of the efficy of prednisolone, montelukast, and omalizumab in an experimental allergic rhinitis model. Turk J Med Sci 2014; 44: 439-47.
568
Brozek JL, Bousquet J, Baena-Cagnani CE, Bonini S, Canonica GW, Casale TB, et al; Global Allergy and Asthma European Network; Grading of Recommendations Assessment, Development and Evaluation Working Group. Allergic Rhinitis and its Impact on Asthma (ARIA) Guideline: 2010 revision. J Allergy Clin Immunol 2010; 126: 466- 76.
569
Arnold DH, Bowman N, Reiss TF, Hartert TV, Seger DL. Adverse events are rare after single-dose montelukast exposures in children. Clin Toxicol (Phila) 2018; 56: 25-29.
570
Calapai G, Casciaro M, Miroddi M, Calapai F, Navarra M, Gangemi S. Montelukast-induced adverse drug reactions: a review of case reports in the literature. Pharmacology 2014; 94: 60-70.
571
Kocyigit A, Gulcan Oksuz B, Yarar F, Uzun F, Igde M, Islek I. Hallucination development with montelukast in a child with asthma: case presentation. Iran J Allergy Asthma Immunol 2013; 12: 397-9.
572
Rx Media Pharma 2018 İnteraktif İlaç Bilgi Kaynağı [Internet]. GEMAŞ A.Ş. 2018 [cited 2020 20 December]. Available from: www.rxmediapharma.com.
573
Liu G, Zhou X, Chen J, Liu F. Oral antihistamines alone vs in combination with leukotriene receptor antagonists for allergic rhinitis: A meta-analysis. Otolaryngol Head Neck Surg 2018; 158: 450-458.
574
Cingi C, Toros SZ, Ince I, Ertugay CK, Gurbuz MK, Cakli H, et al. Does desloratadine alter the serum levels of montelukast when administered in a fixed-dose combination? Laryngoscope 2013; 123: 2610-4.
575
Cingi C, Oghan F, Eskiizmir G, Yaz A, Ural A, Erdogmus N. Desloratadine-montelukast combination improves quality of life and decreases nasal obstruction in patients with perennial allergic rhinitis. Int Forum Allergy Rhinol 2013; 3: 801-6.
576
Badorrek P, Dick M, Schauerte A, Hecker H, Murdoch R, Luettig B, et al. A combination of cetirizine and pseudoephedrine has therapeutic benefits when compared to single drug treatment in allergic rhinitis. International journal of clinical pharmacology and therapeutics 2009; 47: 71-7.
577
Klimek L, Poletti SC, Sperl A, Spielhaupter M, Bardenhewer C, Mullol J, et al. Olfaction in patients with allergic rhinitis: an indicatorof successful MP-AzeFlu therapy. Int Forum Allergy Rhinol 2017; 7: 287-92.
578
Grubbe RE, Lumry WR, Anolik R. Efficacy and safety of desloratadine/pseudoephedrine combination vs its components in seasonal allergic rhinitis. Journal of investigational allergology & clinical immunology 2009; 19: 117-24.
579
Wolthers OD. New patents of fixed combinations of nasal antihistamines and corticosteroids in allergic rhinitis. Recent patents on inflammation & allergy drug discovery 2013; 7: 223-8.
580
Klimek L, Bousquet J, Price D. Safety evaluation of MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate) for allergic rhinitis. Expert Opin Drug Saf 2016; 15: 117-29.
581
Guo L, Sun X, Yang J, Liu J, Wang D. [Clinical study of the combination therapy with intranasal antihistamine and nasal corticosteroids in the treatment of nasal obstruction of persistent non-allergic rhinitis]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 2015; 29: 243-5.
582
Klimek L, Bachert C, Mosges R, Munzel U, Price D, Virchow JC, et al. Effectiveness of MP29-02 for the treatment of allergic rhinitis in real-life: results from a noninterventional study. Allergy and asthma proceedings 2015; 36: 40-7.
583
Berger W, Bousquet J, Fox AT, Just J, Muraro A, Nieto A, et al. MP-AzeFlu is more effective than fluticasone propionate for the treatment of allergic rhinitis in children. Allergy 2016; 71: 1219-22.
584
Dollner R, Lorentz Larsen P, Dheyauldeen S, Steinsvag S. A multicenter, prospective, noninterventional study in a Norwegian cohort of patients with moderate-to-severe allergic rhinitis treated with MP-AzeFlu. Allergy & rhinology (Providence, RI) 2017; 8: 148-56.
585
Devillier P, Dreyfus JF, Demoly P, Calderon MA. A meta-analysis of sublingual allergen immunotherapy and pharmacotherapy in pollen-induced seasonal allergic rhinoconjunctivitis. BMC medicine 2014; 12: 71.
586
Greiwe JC, Bernstein JA. Combination therapy in allergic rhinitis: What works and what does not work. Am J Rhinol Allergy 2016; 30: 391-6.
587
Prenner BM. A review of the clinical efficacy and safety of MP-AzeFlu, a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate, in clinical studies conducted during different allergy seasons in the US. Journal of asthma and allergy 2016; 9: 135-43.
588
Meltzer EO, Bernstein DI, Prenner BM, Berger WE, Shekar T, Teper AA. Mometasone furoate nasal spray plus oxymetazoline nasal spray: short-term efficacy and safety in seasonal allergic rhinitis. Am J Rhinol Allergy 2013; 27: 102-8.
589
Baena-Cagnani CE, Gómez RM. Current status of therapy with omalizumab in children. Curr Opin Allergy Clin Immunol 2014; 14: 149-54.
590
Tsabouri S, Tseretopoulou X, Priftis K, Ntzani EE. Omalizumab for the treatment of inadequately controlled allergic rhinitis: a systematic review and meta-analysis of randomized clinical trials. J Allergy Clin Immunol Pract 2014; 2: 332-40.e1.
591
Kuehr J, Brauburger J, Zielen S, Schauer U, Kamin W, Von Berg A, et al. Efficacy of combination treatment with anti-IgE plus specific immunotherapy in polysensitized children and adolescents with seasonal allergic rhinitis. J Allergy Clin Immunol 2002; 109: 274-80.
592
Casale TB, Busse WW, Kline JN, Ballas ZK, Moss MH, Townley RG, et al; Immune Tolerance Network Group. Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis. J Allergy Clin Immunol 2006; 117: 134-40.
593
Ciprandi G, Marseglia GL, Castagnoli R, Valsecchi C, Tagliacarne C, Caimmi S, et al. From IgE to clinical trials of allergic rhinitis. Expert Rev Clin Immunol 2015; 11: 1321-33.
594
Kopp MV, Hamelmann E, Bendiks M, Zielen S, Kamin W, Bergmann KC, et al; DUAL study group. Transient impact of omalizumab in pollen allergic patients undergoing specific immunotherapy. Pediatr Allergy Immunol 2013; 24: 427-33.
595
Vashisht P, Casale T. Omalizumab for treatment of allergic rhinitis. Expert Opin Biol Ther 2013; 13: 933-45.
596
Bekçibaşı M, Barutçu S, Çelen MK, Dayan S, Hoşoğlu S. Churg-Strauss syndrome occurring during omalizumab treatment. European Journal of Rheumatology 2015; 2: 129-30.
597
Platt M. Pharmacotherapy for allergic rhinitis. Int Forum Allergy Rhinol 2014; 4: S35-40.
598
Ratner PH, Ehrlich PM, Fineman SM, Meltzer EO, Skoner DP. Use of intranasal cromolyn sodium for allergic rhinitis. Mayo Clin Proc 2002; 77: 350-4.
599
Meltzer EO; NasalCrom Study Group. Efficacy and patient satisfaction with cromolyn sodium nasal solution in the treatment of seasonal allergic rhinitis: a placebo-controlled study. Clin Ther 2002; 24: 942-52.
600
Long A, McFadden C, DeVine D, Chew P, Kupelnick B, Lau J. Management of Allergic and Nonallergic Rhinitis. Evidence Report/Technology Assessment No. 54 (Prepared by New England Medical Center Evidence-based Practice Center under Contract No. 290-97-0019). Rockville, MD: Agency for Healthcare Research and Quality. U.S. Department of Health and Human Services; 2002.
601
Lange B. Wirksamkeit, Kosten-Wirksamkeit und Verträglichkeit topischer intranasaler Arzneimittel zur Behandlung der allergischen Rhinitis. Systematische Review mit Metaanalysen (Teil A) und klinische Studie (Teil B). Düsseldorf: Heinrich-Heine-Universität; 2004.
602
Lejeune M, Lefebvre PP, Delvenne P, El-Shazly AE. Nasal sodium cromoglycate (Lomusol) modulates the early phase reaction of mild to moderate persistent allergic rhinitis in patients mono- sensitized to house dust mite: a preliminary study. Int Immunopharmacol 2015; 26: 272-6.
603
Lange B, Lukat KF, Rettig K, Holtappels G, Bachert C. Efficacy, cost- effectiveness, and tolerability of mometasone furoate, levocabastine, and disodium cromoglycate nasal sprays in the treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2005; 95: 272-82.
604
IG, Campbell LM, Harrison JM, Fell PJ, Ellers-Lenz B, Petzold U. Comparison of the efficacy and tolerability of topically administered azelastine, sodium cromoglycate and placebo in the treatment of seasonal allergic conjunctivitis and rhino-conjunctivitis. Curr Med Res Opin 2003; 19: 313-20.
605
Keleş N. Treatment of allergic rhinitis during pregnancy. Am J Rhinol 2004; 18: 23-8.
606
Deveci İ,Deveci HS, Güneş P. Sodyum Kromoglikatın Sağlıklı Sıçan Nazal Mukozası Üzerinde Yarattığı Histopatolojik Değişikliklerin Işık Mikroskobu ile İncelenmesi. Türk Otolarengoloji Arşivi 2013; 51: 45-48.
607
Corboz MR, Rivelli MA, Mingo GG, McLeod RL, Varty L, Jia Y, et al. Mechanism of decongestant activity of alpha 2-adrenoceptor agonists. Pulm Pharmacol Ther 2008; 21: 449-54.
608
Laccourreye O, Werner A, Giroud JP, Couloigner V, Bonfils P, Bondon-Guitton B. Benefits, limits and danger of ephedrine and pseudoephedrine as nasal decongestants. Eur Ann Otorhinolaryngol Head Neck Dis 2015; 132: 31- 4.
609
Johnson DA, Hrick JG. The pharmacology of alpha-adrenergic decongestants. Pharmacotherapy 1993; 13: 110-5.
610
Yoon BW, Bae HJ, Hong KS, Lee SM, Park BJ, Yu KH, et al. Phenylpropanolamine contained in cold remedies and risk of hemorrhagic stroke. Neurology 2007; 68: 146-9.
611
Salerno SM, Jackson JL, Berbano EP. The impact of oral phenylpropanolamine on blood pressure: a meta-analysis and review of the literature. J Hum Hypertens 2005; 19: 643-52.
612
Horak F, Zieglmayer P, Zieglmayer R, Lemell P, Yao R, Staudinger H, et al. A placebo-controlled study of the nasal decongestant effect of phenylephrine and pseudoephedrine in the Vienna Challenge Chamber. Ann Allergy Asthma Immunol 2009; 102: 116-20.
613
Meltzer EO, Ratner PH, McGraw T. Oral phenylephrine HCl for nasal congestion in seasonal allergic rhinitis: a randomized, open-label, placebocontrolled study. J Allergy Clin Immunol Pract 2015; 3: 702-8.
614
Meltzer EO, Ratner PH, McGraw T. Phenylephrine hydrochloride modified-release tablets for nasal congestion: a randomized, placebo-controlled trial in allergic rhinitis patients. Ann Allergy Asthma Immunol 2016; 116: 66-71.
615
Salerno SM, Jackson JL, Berbano EP. Effect of oral pseudoephedrine on blood pressure and heart rate: a meta- analysis. Arch Intern Med 2005; 165: 1686-94.
616
Licari A, Castagnoli R, Bottino C, Marseglia A, Marseglia G, Ciprandi G. Emerging drugs for the treatment of perennial allergic rhinitis. Expert Opin Emerg Drugs 2016; 21: 57-67.
617
Mortuaire G, de Gabory L, François M, Massé G, Bloch F, Brion N, et al. Rebound congestion and rhinitis medicamentosa: nasal decongestants in clinical practice. Critical review of the literature by a medical panel. Eur Ann Otorhinolaryngol Head Neck Dis 2013; 130: 137-44.
618
Ridolo E, Caminati M, Martignago I, Melli V, Salvottini C, Rossi O, et al. Allergic rhinitis: pharmacotherapy in pregnancy and old age. Expert Rev Clin Pharmacol 2016; 9: 1081-1089.
619
Naclerio R. Anticholinergic drugs in nonallergic rhinitis. World Allergy Organ J 2009; 2: 162-5.
620
Dockhorn R, Aaronson D, Bronsky E, Chervinsky P, Cohen R, Ehtessabian R,et al. Ipratropium bromide nasal spray 0.03% and beclomethasone nasal spray alone and in combination for the treatment of rhinorrhea in perennial rhinitis. Ann Allergy Asthma Immunol 1999; 82: 349-59.
621
dMilgrom H, Biondi R, Georgitis JW, Meltzer EO, Munk ZM, Drda K, et al. Comparison of ipratropium bromide 0.03% with beclomethasone dipropionate in the treatment of perennial rhinitis in children. Ann Allergy Asthma Immunol 1999; 83: 105-11.
622
Kim KT, Kerwin E, Landwehr L, Bernstein JA, Bruner D, Harris D, et al; Pediatric Atrovent Nasal Spray Study Group. Use of 0.06% ipratropium bromide nasal spray in children aged 2 to 5 years with rhinorrhea due to a common cold or allergies. Ann Allergy Asthma Immunol 2005; 94: 73-9. [
623
Hanci D, Şahin E, Muluk NB, Cingi C. Immunotherapy in all aspects. Eur Arch Oto-Rhino-Laryngology 2016; 273: 1347-55.
624
Varez-Cuesta E, Bousquet J, Canonica GW, Durham SR, Malling HJ, Valovirta E. Standards for practical allergen- specific immunotherapy 2078. Allergy 2006; 61: 1-20.
625
Kucuksezer UC, Ozdemir C, Akdis M, Akdis CA. Mechanisms of immune tolerance to allergens in children. Korean J Pediatr 2013; 56: 505-13.
626
Passalacqua G, Canonica GW. Allergen Immunotherapy: History and Future Developments. Immunol Allergy Clin North Am 2016; 36: 1-12.
627
Çanakçioğlu S. İmmünoterapi. Türkiye Klinikleri J Allergy-Special Topics 2010; 3: 43-7.
628
Roberts G, Pfaar O, Akdis CA, Ansotegui IJ, Durham SR, Gerth van Wijk R, et al. EAACI Guideline on Allergen Immunotherapy: Allergic rhinoconjunctivitis. Allergy 2018; 73: 765-98.
629
Cox L, Nelson H, Lockey R, Calabria C, Chacko T, Finegold I, et al. Allergen immunotherapy: A practice parameter third update. J Allergy Clin Immunol 2011; 127: S1-55.
630
Canonica GW, Bousquet J, Casale T, Lockey RF, Baena-Cagnani CE, Pawankar R, et al. Sublingual immunotherapy: World Allergy Organization Position Paper 2009. Allergy 2009; 64: 1-59.
631
Canonica GW, Cox L, Pawankar R, Baena-Cagnani CE, Blaiss M, Bonini S, et al. Sublingual immunotherapy: World Allergy Organization position paper 2013 update. World Allergy Organ J 2014; 7: 6.
632
Burks AW, Calderon MA, Casale T, Cox L, Demoly P, Jutel M, et al. Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/ European Academy of Allergy and Clinical Immunology/PRACTALL consensus report. J Allergy Clin Immunol 2013; 131: 1288-96.e3.
633
Wilson DR, Lima MT, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta- analysis. Allergy 2005; 60: 4-12.
634
Malling HJ, Bousquet J. Subcutaneous immunotherapy for allergic rhinoconjunctivitis, allergic asthma, and prevention of allergic diseases. Clin Allergy Immunol 2008; 21: 343-58.
635
Bousquet J, Schünemann HJ, Samolinski B, et al. World Health Organization Collaborating Center for Asthma and Rhinitis. Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. J Allergy Clin Immunol 2012; 130: 1049-62.
636
Durham SR, Walker SM, Varga EM, Jacobson MR, O’Brien F, Noble W, et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 1999; 341: 468-75.
637
Des Roches A, Paradis L, Knani J, Hejjaoui A, Dhivert H, Chanez P, et al. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. V. Duration of the efficacy of immunotherapy after its cessation. Allergy 1996; 51: 30-3
638
Ebner C, Kraft D, Ebner H. Booster immunotherapy (BIT). Allergy 1994; 49: 38-42.
639
Ciprandi G, Klersy C, Cirillo I, Marseglia GL. Quality of life in allergic rhinitis: relationship with clinical, immunological, and functional aspects. Clin Exp Allergy 2007; 37: 1528-35.
640
Guideline on the clinical development of products for specific immunotherapy for the treatment of allergic diseases: European Medicines Agency (EMEA). Committee for Medicinal Products of Human Use; 2008. Report No: CHMP/ EWP/18504/2006.
641
Canonica GW, Baena-Cagnani CE, Bousquet J, Bousquet PJ, Lockey RF, Malling HJ, et al. Recommendations for standardization of clinical trials with allergen specific immunotherapy for respiratory allergy: a statement of a World Allergy Organization (WAO) taskforce. Allergy 2007; 62: 317-24.
642
MarognaM, Spadolini I, Massolo A, Canonica GW, Passalacqua G. Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study. J Allergy Clin Immunol (Internet) 2010; 126: 969-75.
643
Scadding GW, Calderon MA, Shamji MH, Eifan AO, Penagos M, Dumitru F, et al. Effect of 2 years of treatment with sublingual grasspollen immunotherapy on nasal response to allergen challenge at 3 years among patients with moderate to severe seasonal allergic rhinitis. Jama (Internet) 2017; 317: 615.
644
Stelmach I, Sobocinska A, Majak P, Smejda K, Jerzynska J, Stelmach W. Comparison of the long-term efficacy of 3- and 5-year house dust mite allergen immunotherapy. Ann Allergy Asthma Immunol 2012; 109: 274-8.
645
Gupta K, Kumar S, Das M, et al. Peptide based immunotherapy: a pivotal tool for allergy treatment. Intl Immunopharmacol 2014; 19: 391-8.
646
Couroux P, Patel D, Armstrong K, Larché M, Hafner RP, et al. Fel d 1-derived synthetic peptide immuno-regulatory epitopes show a long-term treatment effect in cat allergic subjects. Clin Exp Allergy 2015; 45: 974-81.
647
Valenta R, Niespondziana K, Focke-Tejkl M, Marth K, Huber H, Neubauer A, et al. Recombinant allergens: what does the future hold? J Allergy Clin Immunol 2011; 127: 860-4.
648
Scheiblhofer S, Thaalhamer J, Weiss R. Novel vaccines for type I allergy. Molec Vacc 2014; 2: 490-9.
649
Reisacher W, Liotta D, Yazdi S, Putnam D. Desensitizing mice to ovalbumin through subcutaneous microsphere immunotherapy (SMITH). Int Forum Allergy Rhinol 2011; 1: 390-5.
650
Scholl I, Weissenbock A, Forster-Waldl E, Untersmayr E, Walter F, Willheim M, et al. Allergen-loaded biodegradable poly(D,L-lactic-co-glycolic) acid nanoparticles down-regulate an ongoing Th2 esponse in the BALB/c mouse model. Clin Exp Allergy 2004; 34: 315-21.
651
Roxbury CR, Lin SY. Efficacy and Safety of Subcutaneous and Sublingual Immunotherapy for Allergic Rhinoconjunctivitis and Asthma. Otolaryngologic Clinics of North America 2017; 50: 1111-9.
652
Nelson HS. Injection Immunotherapy for Inhalant Allergens. Middleton’s Allergy. 8th ed. 2014. p.1416-37.
653
Özdemir Ö, Elmas B. Allerjik Rinit Tanı ve Tedavisindeki Yenilikler. Astım Allerji İmmünoloji Dergisi 2017; 15: 1-16.
654
Onbaşı K. Sublingual İmmünoterapi. A Ünitesi. 2017; 2: 8-17.
655
Cekic S, Sapan N. Alerjen Spesifik İmmünoterapi. Güncel Pediatri 2015; 13: 46-55.
656
Göksel Ö. Alerjen spesifik immünoterapi: uzun dönem etkinlik sonuçlarımız. A.Ü Tıp Fakültesi Göğüs Hastalıkları Anabilim Dalı Allerji Bilim Dalı, Yan Dal Uzmanlık Tezi. 2008.
657
Mısırlıgil Z, Sin BA, İkincioğulları A, Güloğlu D, Özdemir K S. Polene duyarlı allerjik rinitli hastalarda mevsim öncesi allergoid immünoterapinin klinik ve immünolojik etkileri: spesifik Ig E ve Ig G4’ün Klinik Etkinlikteki Rolü, Ankara Üniversitesi Bilimsel Araştırma Projesi Kesin Raporu. 2012.
658
Dursun AB, Sin BA, Öner F, Mısırlıgil Z. The safety of allergen immunotherapy (IT) in Turkey. J Investig Allergol Clin Immunol 2006; 16: 123-128.
659
Pasaoglu G, Sin BA, Misirligil Z. Rush Hymenoptera Venom Immunotherapy is Efficacious and Safe. J Investing Allergol Clin Immunol 2006; 16: 232-8
660
Keleş N, Ilıcalı C. Ö, Değer K. İmmünoterapinin allerjik rinit üzerindeki etkinliği: klinik değerlendirme ve rinomanometrik ölçüm. K.B.B.ve Baş Boyun Cerrahisi Dergisi 1997; 5 : 141-4.
661
Polosa R, Gotti Li F, Mangano G, Paolıno G, Mastruzzo C, Vancherıc C ve ark. Allerjik rinitte, astım gelisimi, bronsiyal asırı duyarlılık ve balgam eozinofilisi üzerine immünoterapinin etkisi. Türkiye Klinikleri J Allergy-Asthma 2004; 6: 117-22.
662
Cox L, Linnemann DL, Lockey RF, Passalacqua G. Speaking the same language: The World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System. J Allergy Clin. Immunol 2010; 125: 569-74.
663
Song Y, Long J, Wang T, Xie J, Wang M, Tan G. Long-term efficacy of standardised specific subcutaneous immunotherapy in children with persistent allergic rhinitis due to multiple allergens including house dust mites. J Laryngol Otol 2018; 132: 230-5.
664
Jutel M, Agache I, Bonini S, Burks AW, Calderon M, Canonica W, et al. International consensus on allergy immunotherapy. J Allergy Clin Immunol 2015; 136: 556-68.
665
Dursun AB, Sin BA, Öner F, Mısırlıgil Z. The Safety of Allergen Immunotherapy (IT) in Turkey. J Investig Allergol Clin Immunol 2006; 16: 123-8.
666
Yonekura S, Okamoto Y, Sakurai D, Okubo K, Gotoh M, Kaneko S, et al. An analysis of factors related to the effect of sublingual immunotherapy on Japanese cedar pollen induced allergic rhinitis. Allergol Int 2018;67: 201-8.
667
Incorvaia C, Di Rienzo A, Celani C, Makrì E, Frati F. Treating allergic rhinitis by sublingual immunotherapy: a review. Ann Ist Super Sanita 2012; 48: 172-6.
668
Vadlamudi A, Shaker M. New developments in allergen immunotherapy. Curr Opin Pediatr 2015; 27: 649-55.
669
Lin SY.Sublingual immunotherapy: currentconcepts for the U.S. practitioner. Int Forum Allergy Rhinol 2014; 4: S55-9.
670
Passalacqua G, Compalati E, Canonica GW. Sublingual immunotherapy for allergic rhinitis: an update. Curr Opin Otolaryngol Head Neck Surg 2011; 19: 43-7.
671
Passalacqua G, Canonica GW. Allergen Immunotherapy: History and Future Developments. Immunol Allergy Clin North Am 2016; 36: 1-12.
672
Calderón MA, Simons FE, Malling HJ, Lockey RF, Moingeon P, Demoly P. Sublingual allergen immunotherapy: mode of action and its relationship with the safety profile. Allergy 2012; 67: 302-11.
673
Demoly P, Calderon MA. Dosing and efficacy in specific immunotherapy. Allergy 2011; 66: 38-40.
674
Demoly P, Passalacqua G, Calderon MA, Yalaoui T. Choosing the optimaldose in sublingual immunotherapy: Rationale for the 300 index of reactivity dose. Clin Transl Allergy 2015; 5: 44.
675
Gunel C, Basak HS. Sublingual immunotherapy in treatment of allergic rhinitis. Turkish J Rhinology 2014; 3: 9.
676
Moingeon P, Batard T, Fadel R, Frati F, Sieber J, Van Overtvelt L. Immunemechanisms of allergen-specificsublingual immunotherapy. Allergy 2006; 61: 151-65.
677
Allam JP, Peng WM, Appel T, Wenghoefer M, Niederhagen B, Bieber T, et al. Toll-like receptor 4ligationenforcestolerogenicproperties of oral mucosalLangerhans cells. J Allergy Clin Immunol 2008; 121: 368-74.
678
Özdemir C, Bahçeciler N, Barlan İ. Sublingual İmmünoterapi. Güncel Pediatri 2006; 4: 137-9.
679
Allam JP, Niederhagen B, Bücheler M, Appel T, Betten H, Bieber T, et al. Comparative analysis of nasal and oral mucosa dendritic cells. Allergy 2006; 61: 166-72.
680
Meiler F, Zumkehr J, Klunker S, Rückert B, Akdis CA, Akdis M. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med 2008; 205: 2887-98.
681
Jutel M, Akdis M, Budak F, Aebischer-Casaulta C, Wrzyszcz M, Blaser K, et al. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003; 33: 1205-14.
682
Zuberier T, Bachert C, Bousquet PJ, Passalacqua G, Walter Canonica G, Merk H, et al. GA2LEN/EAACI pocket guide for allergen-specific immunotherapy for allergic rhinitis and asthma. Allergy 2010; 65: 1525-30.
683
Milani M. Allergen-specificimmunotherapy for allergicrhinitis in the elderly: is it nevertoolate? Immunotherapy 2013; 5: 699-702.
684
Cingi C, Birdane L. Apractical approach to sublingual immunotherapy. Current manegment in otorhinolaryngology head and neck surgery 2007; 3: 62-64.
685
Bousquet PJ, Demoly P, Passalacqua G, Canonica GW, Bousquet J. Immunotherapy: clinical trials-optimal trial and clinical outcomes. Curr Opin Allergy Clin Immunol 2007; 7: 561-6.
686
Eifan AO, Keles S, Bahceciler NN, Barlan IB. Anaphylaxis to multiple pollen allergen sublingual immunotherapy. Allergy 2007; 62: 56-78.
687
Didier A, Campo P, Moreno F, Durand-Perdriel F, Marin A, Chartier A. Dose-DependentImmunologicalResponsesaf ter a 6-MonthCourse of SublingualHouseDustMiteImmunotherapy in Patients with AllergicRhinitis. Int Arch Allergy Immunol 2015; 168: 182-92.
688
Antico A, Pagani M, Crema A. Anaphylaxis by latex sublingual immunotherapy. Allergy 2006; 61: 1236-7.
689
Blazowski L. Anaphylactic shock because of sublingual immunotherapy overdose during third year of maintenance dose. Allergy 2008; 63: 374.
690
Dunsky EH, Goldstein MF, Dvorin DJ, Belecanech GA. Anaphylaxis to sublingual immunotherapy. Allergy 2006; 61: 1235.
691
Mosbech H, Canonica GW, Becker V, de Blay F, Klimek L, Broge L, et al. SQ house dust mite sublingually administered immunotherapy tablet (ALK) improves allergic rhinitis in patients with house dust mite allergic asthma and rhinitis symptoms. Ann Allergy Asthma Immunol 2015; 114: 134-40.
692
Li JT, Bernstein DI, Calderon MA, Casale TB, Cox L, Passalacqua G, et al. Sublingual grass and rag- weed immunotherapy: clinical considerations - a PRACTALL con- sensus report. J Allergy Clin Immunol 2016; 137: 369-76.
693
Durham SR, Emminger W, Kapp A, de Monchy JG, Rak S, Scadding GK, et al. SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial. J Allergy Clin Immunol 2012; 129: 717-25.
694
Dahl R, Roberts G, de Blic J, Canonica GW, Kleine-Tebbe J, Nolte H, et al. SQ grass sublingual allergy immunotherapy tablet for disease-modifying treatment of grass pollen allergic rhinoconjunctivitis. Allergy Asthma Proc 2016; 37: 92-104.
695
Nelson HS. Oral/sublingual Phleum pretense grass tablet (Grazax/ Grastek) to treat allergic rhinitis in the USA. Expert Rev Clin Immunol 2014; 10: 1437-51.
696
Cox LS, Linneman DL, Nolte H, Weldon D, Finegold I, Nelson HS. Sublingual immunotherapy: a comprehensive review. J Allergy Clin Immunol 2006; 117: 1021-35.
697
Antico A, Fante R. Esophageal hypereosinophilia induced by grass sublingual immunotherapy. J Allergy Clin Immunol 2014; 133: 1482-84.
698
Creticos PS, Esch RE, Couroux P, Gentile D, D’Angelo P, Whitlow B, et al. Randomized, double-blind, placebo- controlled trial of standardized ragweed sublingual-liquid immunotherapy for allergic rhinoconjunctivitis. J Allergy Clin Immunol 2014; 133: 751-58.
699
Reid MJ, Lockey RF, Turkeltaub PC, Platts-Mills TA. Survey of fatalities from skin testing and immunotherapy 1985- 1989.J Allergy Clin Immunol 1993; 92: 6-15.
700
Bousquet J, Demoly P, Michel FB. Specific immunotherapy in rhinitis and asthma.Ann Allergy Asthma Immunol 2001; 87: 38-42.
701
Reisacher W, Rudner S, Kotik V. Oral mucosal immunotherapy using a toothpaste delivery system for the treatment of allergic rhinitis. Int J Pharm Compd 2014; 18: 287-90.
702
Calderon MA, Alves B, Jacobson M, Hurwitz B, Sheikh A, Durham S. Allergen injection immunotherapy for seasonal allergic rhinitis. Cochrane Database Syst Rev 2007; 2007: CD001936.
703
Didier A, Worm M, Horak F, Sussman G, de Beaumont O, Le Gall M, Melac M, Malling HJ. Sustained 3-year efficacy of pre- and coseasonal 5-grass-pollen sublingual immunotherapy tablets in patients with grass pollen-induced rhinoconjunctivitis J Allergy Clin Immunol 2011; 128: 559-66.
704
Ant K, Pearce N, Anderson HR, Ellwood P, Montefort S, Shah J. Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood ISAAC Phase Three. Allergy 2009; 64: 123-48.
705
Hill DA, Grundmeier RW, Ram G, Spergel JM The epidemiologic characteristics of healthcare provider-diagnosed eczema, asthma, allergic rhinitis, and food allergy in children: a retrospective cohort study. BMC Pediatr 2016; 16: 133.
706
Belgrave DC, Granell R, Simpson A, Guiver J, Bishop C, Buchan I, Henderson AJ, Custovic A. Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies. PLoS Med 2014; 11: e1001748.
707
Westman M, Stjärne P, Asarnoj A, Kull I, van Hage M, Wickman M, et al. Natural course and comorbidities of allergic and nonallergic rhinitis in children. J Allergy Clin Immunol 2012; 129: 403-8.
708
Matheson MC, Dharmage SC, Abramson MJ, Walters EH, Sunyer J, de Marco R, et al. Early-life risk factors and incidence of rhinitis: results from the European Community Respiratory Health Study--an international population-based cohort study. J Allergy Clin Immunol 2011; 128: 816-23.
709
Beckhaus AA, Garcia-Marcos L, Forno E, Pacheco-Gonzalez RM, Celedon JC, Castro-Rodriguez JA. Maternal nutrition during pregnancy and risk of asthma, wheeze, and atopic diseases during childhood: a systematic review and meta-analysis. Allergy 2015; 70: 1588-604.
710
Zhang G-Q, Liu B, Li J, Luo CQ, Zhang Q, Chen JL, Sinha A, Li ZY Fish intake during pregnancy or infancy and allergic outcomes in children: A systematic review and meta-analysis Pediatr Allergy Immunol 2017; 28: 152-61.
711
Kim YH, Kim KW, Kim MJ, Sol IS, Yoon SH, Ahn HS, Kim HJ, Sohn MH, Kim K-E. Vitamin D levels in allergic rhinitis: a systematic review and meta-analysis. Pediatr Allergy Immunol 2016: 27: 580-90.
712
Ahmadizar F, Vijverberg SJH, Arets HGM, de Boer A, Lang JE, Garssen J, et al. Early-life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta-analysis. Allergy 2018; 73: 971-86.
713
Vázquez-Nava F, Quezada-Castillo JA, Oviedo-Treviño S, Saldivar-González AH, Sánchez-Nuncio HR, Beltrán- Guzmán FJ, et al. Association between allergic rhinitis, bottle feeding, non-nutritive sucking habits, and malocclusion in the primary dentition. Arch Dis Child 2006; 91: 836-40.
714
Bachert C, Vignola AM, Gevaert P, Leynaert B, Van Cauwenberge P, Bousquet J.Allergic rhinitis, rhinosinusitis, and asthma: one airway disease. Immunol Allergy Clin North Am 2004; 24: 19-43.
715
Bertelsen RJ, Carlsen KC, Carlsen KH. Rhinitis in children: co-morbidities and phenotypes Pediatr Allergy Immunol 2010; 21: 612-22.
716
Roberts G, Xatzipsalti M, Borrego LM, Custovic A, Halken S, Hellings PW, et al. Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy 2013; 68: 1102-16.
717
Fokkens WJ, Lund VJ, Mullol J, Bachert C, Alobid I, Baroody F et.al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. Rhinology 2012; 50: 1-12.
718
Tharpe AC, Kemp SF. Pediatric allergic rhinitis. Immunol Allergy Clin North Am 2015; 35: 185-98.
719
Brawley A, Silverman B, Kearney S, Guanzon D, Owens M, Bennett H, Schneider A. Allergic rhinitis in children with attention-deficit/hyperactivity disorder. Ann Allergy Asthma Immunol 2004; 92: 663-7.
720
Marshall PS, O’Hara C, Steinberg P. Effects of seasonal allergic rhinitis on fatigue levels and mood. Psychosom Med 2002; 64: 684-91.
721
Walker S, Khan-Wasti S, Fletcher M, Cullinan P, Harris J, Sheikh A. Seasonal allergic rhinitis is associated with a detrimental effect on examination performance in United Kingdom teenagers: case-control study. J Allergy Clin Immunol 2007; 120: 381-7.
722
Vuurman EF, van Veggel LM, Uiterwijk MM, Leutner D, O’Hanlon JF. Seasonal allergic rhinitis and antihistamine effects on children’s learning. Ann Allergy 1993; 71: 121-6.
723
Jáuregui I, Mullol J, Dávila I, Ferrer M, Bartra J, del Cuvillo A, Montoro J, Sastre J, Valero A. Allergic rhinitis and school performance. J Investig Allergol Clin Immunol 2009; 19: 32-9.
724
Schans JV, Çiçek R, de Vries TW, Hak E, Hoekstra PJ. Association of atopic diseases and attention-deficit/ hyperactivity disorder: A systematic review and meta-analyses. Neurosci Biobehav Rev 2017; 74: 139-48.
725
Trikojat K, Buske-Kirschbaum A, Schmitt J, Plessow F. Altered performance in attention tasks in patients with seasonal allergic rhinitis: seasonal dependency and association with disease characteristics. Psychol Med 2015; 45: 1289-99.
726
Melamed I, Heffron M. Attention Deficit Disorder and Allergic Rhinitis: Are They Related? J Immunol Res. 2016; 2016: 1596828.
727
Cheng H, Deighton J, Wolpert M, Chapman BP, Kornilaki EN, Treglown L, Furnham A. Hay fever in childhood, traits Neuroticism and Conscientiousness as independent predictors of the occurrence of hay fever in adulthood. J Health Psychol 2016; 21: 2367-75.
728
Miyazaki C, Koyama M, Ota E, Swa T, Mlunde LB, Amiya RM, et al. Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis. BMC Psychiatry 2017; 17: 120.
729
Arroyave WD, Rabito FA, Carlson JC, Friedman EE, Stinebaugh SJ. Impermeable dust mite covers in the primary and tertiary prevention of allergic disease: a meta-analysis. Ann Allergy Asthma Immunol 2014; 112: 237-48.
730
Bielory L Ocular symptom reduction in patients with seasonal allergic rhinitis treated with the intranasal corticosteroid mometasone furoate. Ann Allergy Asthma Immunol 2008; 100: 272-9.
731
Mansfield LE, Diaz G, Posey CR, Flores-Neder J Sleep disordered breathing and daytime quality of life in children with allergic rhinitis during treatment with intranasal budesonide. Ann Allergy Asthma Immunol 2004; 92: 240- 4.
732
Van Cauwenberge P, Bachert C, Passalacqua G, Bousquet J, Canonica GW, Durham SR, Consensus statement on the treatment of allergic rhinitis. Allergy 2000; 55: 116-34.
733
Schenkel EJ, Skoner DP, Bronsky EA, Miller SD, Pearlman DS, Rooklin A et.al. Absence of growth retardation in children with perennial allergic rhinitis after one year of treatment with mometasone furoate aqueous nasal spray. Pediatrics 2000; 105: E22.
734
Galant SP, Melamed IR, Nayak AS, Blake KV, Prillaman BA, Reed KD, Lack of effect of fluticasone propionate aqueous nasal spray on the hypothalamic-pituitary-adrenal axis in 2- and 3-year-old patients. Pediatrics 2003; 112: 96-100.
735
Skoner DP, Gentile D, Angelini B , Kane R, Birdsall D, Banerji D The effects of intranasal triamcinolone acetonide and intranasal fluticasone propionate on short-term bone growth and HPA axis in children with allergic rhinitis. Ann Allergy Asthma Immunol 2003; 90: 56-62.
736
Church MK, Maurer M, Simons FER, Bindslev-Jensen C, Van Cauwenberge P, Bousquet J et al. Risk of first- generation H1-antihistamines: a GA2LEN position paper. Allergy 2010; 65: 459-66.
737
Ng KH, Chong D, Wong CK, Ong HT, Lee CY, Lee BW et al. Central nervous system side effects of first- and second-generation antihistamines in school children with perennial allergic rhinitis: a randomized, doubleblind, placebo-controlled comparative study. Pediatrics 2004; 113: e116-e121
738
Gupta SK, Kantesaria B, Banfield C, Wang Z. Desloratadine dose selection in children aged 6 months to 2 years: comparison of population pharmacokinetics between children and adults. Br J Clin Pharmacol 2007; 64: 174- 84.
739
Hampel FC, Kittner B, van Bavel JH. Safety and tolerability of fexofenadine hydrochloride, 15 and 30 mg, twice daily in children aged 6 months to 2 years with allergic rhinitis Ann Allergy Asthma Immunol 2007; 99: 549-54.
740
Grossman J, Halverson PC, Meltzer EO, Shoenwetter WF, van Bavel JH, Woehler TR Double-blind assessment of azelastine in the treatment of perennial allergic rhinitis. Ann Allergy 1994; 73: 141-6.
741
Conde Hernández DJ, Palma Aqilar JL, Delgado Romero J. Comparison of azelastine nasal spray and oral ebastine in treating seasonal allergic rhinitis. Curr Med Res Opin 1995; 13: 299-304.
742
Berlin JM, Golden SJ, Teets S, Lehman EB, Lucas T, Craig TJ. Efficacy of a steroid nasal spray compared with an antihistamine nasal spray in the treatment of perennial allergic rhinitis. J Am Osteopath Assoc 2000; 100: S8-13.
743
Li AM, Abdullah VJ, Tsen CS, Au CT, Lam HS, So HK Leukotriene receptor antagonist in the treatment of childhood allergic rhinitis--a randomized placebo-controlled study. Pediatr Pulmonol 2009; 44: 1085-92.
744
Razi C, Bakirtas A, Harmanci K, Turktas I, Erbas D. Effect of montelukast on symptoms and exhaled nitric oxide levels in 7- to 14-year-old children with seasonal allergic rhinitis. Ann Allergy Asthma Immunol 2006; 97: 767- 74.
745
Philip G, Hustad CM, Malice MP, Noonan G, Ezekowitz A, Reiss TF et. al. Analysis of behavior-related adverse experiences in clinical trials of montelukast. J Allergy Clin Immunol 2009; 124: 699-706.e8.
746
Law SWY, Wong AYS, Anand S, Wong ICK, Chan EW. Neuropsychiatric Events Associated with Leukotriene- Modifying Agents: A Systematic Review. Drug Saf 2018; 41: 253-265.
747
Satdhabudha A, Poachanukoon O Efficacy of buffered hypertonic saline nasal irrigation in children with symptomatic allergic rhinitis: a randomized double-blind study. Int J Pediatr Otorhinolaryngol 2012; 76: 583-8.
748
Garavello W, Romagnoli M, Sordo L, Gaini RM, Di Berardino C, Angrisano A. Hypersaline nasal irrigation in children with symptomatic seasonal allergic rhinitis: a randomized study. Pediatr Allergy Immunol 2003; 14: 140-3.
749
Chen JR, Jin L, Li XY The effectiveness of nasal saline irrigation (seawater) in treatment of allergic rhinitis in children..Int J Pediatr Otorhinolaryngol 2014; 78: 1115-8.
750
Hermelingmeier KE, Weber RK, Hellmich M, Heubach CP, Mösges R. Nasal irrigation as an adjunctive treatment in allergic rhinitis: a systematic review and meta-analysis. Am J Rhinol Allergy 2012; 26: e119-25.
751
Kamin W, Kopp MV, Erdnuess F, Schauer U, Zielen S, Wahn U. Safety of anti-IgE treatment with omalizumab in children with seasonal allergic rhinitis undergoing specific immunotherapy simultaneously.Pediatr Allergy Immunol 2010; 21: e160-5.
752
Rienzo VD, Minelli M, Musarra A, Sambugaro R, Pecora S, Canonica WG, Passalacqua G. Post-marketing survey on the safety of sublingual immunotherapy in children below the age of 5 years. Clin Exp Allergy 2005; 35: 560-4.
753
Canonica GW, Cox L, Pawankar R, Baena-Cagnani CE, Blaiss M, Bonini S, et al. Sublingual immunotherapy: World Allergy Organization position paper 2013 update. World Allergy Organ J 2014; 7: 6.
754
Kristiansen M, Dhami S, Netuveli G, Halken S, Muraro A, Roberts G, Larenas-Linnemann D, et.al. Allergen immunotherapy for the prevention of allergy: A systematic review and meta-analysis. Pediatr Allergy Immunol 2017: 28: 18-29.
755
Larenas-Linnemann D, Blaiss M, Van Bever HP, Compalati E, Baena-Cagnani CE. Pediatric sublingual immunotherapy efficacy: evidence analysis, 2009-2012 Ann Allergy Asthma Immunol 2013; 110: 402-415.e9.
756
Feng B, Wu J, Chen B, Xiang H, Chen R, Li B, et al. Efficacy and safety of sublingual immunotherapy for allergic rhinitis in pediatric patients: A meta-analysis of randomized controlled trials. Am J Rhinol Allergy 2017; 31: 27-35.
757
Khinchi M. S, Poulsen L. K, Carat F, André C, Hansen A. B, Malling H, et.al. Clinical efficacy of sublingual and subcutaneous birch pollen allergen-specific immunotherapy: a randomized, placebo-controlled, double-blind, double-dummy study. Hum Vaccin Immunother 2012 ; 8: 1544-7.
758
Durham SR, Penagos M.Sublingual or subcutaneous immunotherapy for allergic rhinitis? J Allergy Clin Immunol 2016; 137: 339-349.
759
Bohai Feng, Jueting Wu, Bobei Chen, Haijie Xiang, Ruru Chen, Bangliang Li, et.al. Efficacy and safety of sublingual immunotherapy for allergic rhinitis in pediatric patients: A meta-analysis of randomized controlled trials Am J Rhinol Allergy 2017; 31: 27-35.
760
Bousquet J, Agache I, Aliberti MR, Angles R, Annesi-Maesano I, Anto JM et al. Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - EIP on AHA Twinning Reference Site (GARD research demonstration project). Allergy 2018; 73: 77-92.
761
Calderon MA, Demoly P, Casale T, Akdis CA, Bachert C, Bewick M et al. Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies: An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project. Clin Transl Allergy 2016; 6: 41.
762
Ventura MT, Scichilone N, Gelardi M, Patella V, Ridolo E. Management of allergic disease in the elderly: key considerations, recommendations and emerging therapies. Expert Rev Clin Immunol 2015; 11: 1219-28.
763
Pinto JM, Jeswani S. Rhinitis in the geriatric population. Allergy Asthma Clin Immunol 2010; 6: 10.
764
Ventura MT, Scichilone N, Paganelli R, Minciullo PL, Patella V, Bonini M et al. Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms. Clin Mol Allergy 2017; 15: 2.
765
Moro-García MA, Alonso-Arias R, López-Larrea C. Molecular mechanisms involved in the aging of the T-cell immune response. Curr Genomics 2012; 13: 589-602.
766
Ventura MT, Gelardi M, D’Amato A, Buquicchio R, Tummolo R, Misciagna G et al. Clinical and cytologic characteristics of allergic rhinitis in elderly patients. Ann Allergy Asthma Immunol 2012; 108: 141-4.
767
Bozek A, Ignasiak B, Kasperska-Zajac A, Scierski W, Grzanka A, Jarzab J. Local allergic rhinitis in elderly patients. Ann Allergy Asthma Immunol 2015; 114: 199-202.
768
Lombardi C, Raffetti E, Caminati M, Liccardi G, Passalacqua G, Reccardini F et al. Phenotyping asthma in the elderly: allergic sensitization profile and upper airways comorbidity in patients older than 65 years. Ann Allergy Asthma Immunol 2016; 116: 206-11.
769
Bozek A, Jarzab J. Epidemiology of IgE-dependent allergic diseases in elderly patients in Poland.Am J Rhinol Allergy 2013; 27: e140-5.
770
Milgrom H, Huang H. Allergic disorders at a venerable age: a mini-review. Gerontology 2014; 60: 99-107.
771
Nyenhuis SM, Mathur SK. Rhinitis in older adults.Curr Allergy Asthma Rep 2013; 13: 171-7.
772
Bozek A. Pharmacological Management of Allergic Rhinitis in the Elderly. Drugs Aging 2017; 34: 21-28.
773
Karabulut H, Baysal S, Acar B, Babademez MA, Karasen RM. Allergic rhinitis (AR) in geriatric patients. Arch Gerontol Geriatr 2011; 53: 270-3.
774
Baptist AP, Nyenhuis S. Rhinitis in the Elderly.Immunol Allergy Clin North Am 2016; 36: 343-57.
775
Simola M, Holopainene E, Malmberg H. Changes in skin and nasal sensitivity to allergens and the course of rhinitis; a long-term follow-up study. Ann Allergy Asthma Immunol 1999; 82: 152-6.
776
Leurs R, Church MK, Taglialatela M. H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects. Clin Exp Allergy 2002; 32: 489-98.
777
Hansen J, Klimek L, Hörmann K. Pharmacological management of allergic rhinitis in the elderly: safety issues with oral antihistamines. Drugs Aging 2005; 22: 289-96.
778
Affrime M, Gupta S, Banfield C, Cohen A. A pharmacokinetic profile of desloratadine in healthy adults, including elderly. Clin Pharmacokinet 2002; 41: 13-9.
779
Kaliner MA. H1-antihistamines in the elderly. Clin Allergy Immunol 2002; 17: 465-81.
780
Jáuregui I, García-Lirio E, Soriano AM, Gamboa PM, Antépara I. An overview of the novel H1-antihistamine bilastine in allergic rhinitis and urticaria. Expert Rev Clin Immunol 2012; 8: 33-41.
781
Estelle F, Simons R. H1-receptor antagonists: safety issues. Ann Allergy Asthma Immunol 1999; 83: 481-8.
782
Luo X, Ma R, Wu X, Xian D, Li J, Mou Z, et al. Azelastine enhances the clinical efficacy of glucocorticoid by modulating MKP-1 expression in allergic rhinitis. Eur Arch Otorhinolaryngol 2015; 272: 1165-73.
783
Sahin Yilmaz AA, Corey JP. Rhinitis in the elderly. Curr Allergy Asthma Rep 2006; 6: 125-31.
784
Slavin RG. Special considerations in treatment of allergic rhinitis in the elderly: role of intranasal corticosteroids. Allergy Asthma Proc 2010; 31: 179-84.
785
Slavin RG. Treating rhinitis in the older population: special considerations. Allergy Asthma Clin Immunol 2009; 5: 9.
786
Graf P, Juto JE. Decongestion effect and rebound swelling of the nasal mucosa during 4-week use of oxymetazoline. ORL J Otorhinolaryngol Relat Spec 1994; 56: 157-60.
787
Nayak A, Langdon RB. Montelukast in the treatment of allergic rhinitis: an evidence-based review. Drugs 2007; 67: 887-901.
788
Virchow JC, Bachert C. Efficacy and safety of montelukast in adults with asthma and allergic rhinitis. Respir Med 2006; 100: 1952-9.
789
Ciftci Z, Catli T, Hanci D, Cingi C, Erdogan G. Rhinorrhoea in the elderly. Eur Arch Otorhinolaryngol 2015; 272: 2587-92.
790
Bozek A, Kolodziejczyk K, Warkocka-Szoltysek B, Jarzab J.Grass pollen sublingual immunotherapy: a double- blind, placebo-controlled study in elderly patients with seasonal allergic rhinitis.Am J Rhinol Allergy 2014; 28: 423-7.
791
Bozek A, Kolodziejczyk K, Krajewska-Wojtys A, Jarzab J. Ann Allergy Asthma Immunol 2016; 116: 156-61.
792
Bożek A, Kołodziejczyk K, Kozłowska R, Canonica GW. Evidence of the efficacy and safety of house dust mite subcutaneous immunotherapy in elderly allergic rhinitis patients: a randomized, double-blind placebo-controlled trial. Clin Transl Allergy 2017; 7: 43.
793
Pitsios C, Demoly P, Bilò MB, Gerth van Wijk R, Pfaar O, Sturm GJ, et al. Clinical contraindications to allergen immunotherapy: an EAACI position paper. Allergy 2015; 70: 897-909.
794
Gonzalez-Estrada A, Geraci SA. Allergy Medications During Pregnancy. Am J Med Sci 2016; 352: 326-31.
795
Sato K. Treatment of allergic rhinitis during pregnancy. Clin Exp Allergy Rev, 2012 12: 31-36.
796
Schatz M, Zeiger RS. Diagnosis and management of rhinitis during pregnancy. Allergy Proc 1988; 9: 545-54.
797
Pali-Schöll I, Namazy J, Jensen-Jarolim E. Allergic diseases and asthma in pregnancy, a secondary publication. The World Allergy Organization Journal 2017; 10: 10.
798
Ellegård EK. Clinical and pathogenetic characteristics of pregnancy rhinitis. Clin Rev Allergy Immunol 2004; 26: 149-59.
799
Ellegård EK. Pregnancy rhinitis. Immunol Allergy Clin North Am 2006; 26: 119-35.
800
Namazy JA, Schatz M. Diagnosing rhinitis during pregnancy. Curr Allergy Asthma Rep 2014; 14: 458.
801
Schatz M, Zeiger RS. Asthma and allergy in pregnancy. Clin Perinatol 1997; 24: 407-32.
802
Oykhman P, Kim HL, Ellis AK. Allergen immunotherapy in pregnancy. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and. Clin Immunol 2015; 11: 31.
803
Demoly P, Piette V, Daures JP. Treatment of allergic rhinitis during pregnancy. Drugs 2003; 63: 1813-20.
804
Incaudo GA. Diagnosis and treatment of allergic rhinitis and sinusitis during pregnancy and lactation. Clin Rev Allergy Immunol 2004; 27: 159-77.
805
Odedra KM. Treatment of rhinitis in pregnancy. Nurs Stand. 2014 Oct 28;29(8):37-41. doi: 10.7748/ns.29.8.37.e9089. 794. Namazy J, Schatz M. The Treatment of Allergic Respiratory Disease During Pregnancy. J Investig Allergol Clin Immunol 2016; 26: 1-7.
806
Namazy JA, Schatz M. Diagnosing rhinitis during pregnancy. Curr Allergy Asthma Rep 2014;14: 458.
807
Ellegård EK, Hellgren M, Karlsson NG. Fluticasone propionate aqueous nasal spray in pregnancy rhinitis. Clin Otolaryngol Allied Sci 2001; 26: 394-400.
808
Källén BAJ, Otterblad Olausson P. Maternal drug use in early pregnancy and infant cardiovascular defect. Reprod Toxicol 2003; 17: 255-261.
809
Bérard A, Sheehy O, Kurzinger M-L, Juhaeri J. Intranasal triamcinolone use during pregnancy and the risk of adverse pregnancy outcomes. J Allergy Clin Immunol 2016; 138: 97-104.e7
810
NAEPP expert panel report. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. J Allergy Clin Immunol 2005; 115: 34-46.
811
Rodriguez-Pinilla E, Martinez-Frias ML. Corticosteroids during pregnancy and oral clefts: a case control study. Teratology 1998; 58: 2-5.
812
Yawn B, Knudtson M. Treating Asthma and Comorbid Allergic Rhinitis in Pregnancy. J Am Board Fam Med 2007; 20: 289-98.
813
Bandoli G, Palmsten K, Forbess Smith CJ, Chambers CD. A Review of Systemic Corticosteroid Use in Pregnancy and the Risk of Select Pregnancy and Birth Outcomes. Rheum Dis Clin North Am 2017; 43: 489-502.
814
Incaudo GA, Takach P. The diagnosis and treatment of allergic rhinitis during pregnancy and lactation. Immunol Allergy Clin North Am 2006; 26: 137-54.
815
Etwel F, Faught LH, Rieder MJ, Koren G. The Risk of Adverse Pregnancy Outcome After First Trimester Exposure to H1 Antihistamines: A Systematic Review and Meta-Analysis. Drug Saf 2017; 40: 121-32.
816
Gilbert C, Mazzotta P, Loebstein R, Koren G. Fetal safety of drugs used in the treatment of allergic rhinitis: a critical review. Drug Saf 2005; 28: 707-19.
817
Einarson A, Levichek Z, Einarson TR, Koren G. The antiemetic effect of cetirizine during pregnancy. Ann Pharmacother 2000; 34: 1486-7.
818
Scadding GK, Durham SR, Mirakian R, Jones NS, Leech SC, Farooque S, Ryan D, et all. BSACI Guideline for the management of allergic and non-allergic rhinitis. Clin Exp Allergy 2008; 38: 19-42.
819
Werler MM, Mitchell AA, Shapiro S. First trimester maternal medication use in relation to gastroschisis. Teratology 1992; 45: 361-7.
820
Torfs CP, Katz EA, Bateson TF, Lam PK, Curry CJ. Maternal medications and environmental exposures as risk factors for gastroschisis. Teratology 1996; 54: 84-92.
821
Werler MM, Sheehan JE, Mitchell AA. Association of vasoconstrictive exposures with risks of gastroschisis and small intestinal atresia. Epidemiology 2003; 14: 349-54.
822
Werler MM. Teratogen update: pseudoephedrine. Birth Defects Res A Clin Mol Teratol 2006; 76: 445-52.
823
Werler MM, Sheehan JE, Mitchell AA. Maternal medication use and risks of gastroschisis and small intestinal atresia. Am J Epidemiol 2002; 155: 26-31.
824
Rothman KJ, Fyler DC, Goldblatt A, Kreidberg MB. Exogenous hormones and other drug exposures of children with congenital heart disease. Am J Epidemiol 1979; 109: 433-9.
825
Heinonen OP, Slone D, Shapiro S. Drugs affecting the autonomic nervous system. In: Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group, Inc.; 1977:345-356.
826
Källén BA, Olausson PO. Use of oral decongestants during pregnancy and delivery outcome. Am J Obstet Gynecol 2006; 194: 480-5.
827
Yau WP, Mitchell AA, Lin KJ, Werler MM, Hernández-Díaz S. Use of decongestants during pregnancy and the risk of birth defects. Am J Epidemiol 2013; 178: 198-208.
828
Bakhireva LN, Jones KL, Schatz M, Klonoff-Cohen HS, Johnson D, Slymen DJ, et all. Safety of leukotriene receptor antagonists in pregnancy. J Allergy Clin Immunol 2007; 119: 618-25.
829
Källén B, Otterblad Olausson P. Use of anti-asthmatic drugs during pregnancy. 3. Congenital malformations in the infants. Eur J Clin Pharmacol 2007; 63: 383-8.
830
Koren G, Sarkar M, Einarson A. Safety of using montelukast during pregnancy. Can Fam Physician 2010; 56: 881-2.
831
Sarkar M, Koren G, Kalra S, Ying A, Smorlesi C, De Santis M, et all. Montelukast use during pregnancy: a multicentre, prospective, comparative study of infant outcomes. Eur J Clin Pharmacol 2009; 65: 1259-64.
832
Metzger WJ, Turner E, Patterson R. The safety of immunotherapy during pregnancy. J Allergy Clin Immunol 1978; 61: 268-72.
833
Shaikh WA. A retrospective study on the safety of immunotherapy in pregnancy. Clin Exp Allergy 1993; 23: 857-60.
834
Shaikh WA, Shaikh SW. A prospective study on the safety of sublingual immunotherapy in pregnancy. Allergy 2012; 67: 741-3.
835
Glovsky MM, Ghekiere L, Rejzek E. Effect of maternal immunotherapy on immediate skin test reactivity, specific rye I IgG and IgE antibody, and total IgE of the children. Ann Allergy 1991; 67: 21-4.
836
Flicker S, Marth K, Kofler H, Valenta R. Placental transfer of allergen-specific IgG but not IgE from a specific immunotherapy-treated mother. J Allergy Clin Immunol 2009; 124: 1358-60.
837
Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am 2013; 60: 275-94.
838
Datta P, Rewers-Felkins K, Baker T, Hale TW. Transfer of Montelukast into Human Milk During Lactation. Breastfeed Med 2017; 12: 54-57.
839
Hill R.M., Tennyson L.M. The lactating allergic patient: which drugs cause concern for the infant? Immunol Allergy Prac 1984; 6: 221-7.
840
Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol 1993; 168: 1393-9.
841
Hilbert J, Radwanski E, Affrime MB, Perentesis G, Symchowicz S, Zampaglione N. Excretion of loratadine in human breast milk. J Clin Pharmacol 1988; 28: 234-9.
842
Aljazaf K, Hale TW, Ilett KF, Hartmann PE, Mitoulas LR, Kristensen JH et al. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol 2003; 56: 18-24.
843
Silva D, Moreira A., Allergic Rhinitis and Sports, Allergic Rhinitis. InTech, 2012.
844
Katelaris CH., Carrozzi FM., Burke TV., Byth K., Patterns of allergic reactivity and disease in Olympic athletes. Clinical Journal of Sport Medicine 2006; 16: 401-405.
845
Helbling A., Jenoure P., and Müller U., The incidence of hay fever in leading Swiss athletes. 1990, Schweizerische medizinische Wochenschrift 120.7: 231-236.
846
Silva D, Moreira A., The role of sports and exercise in allergic disease: drawbacks and benefits., Expert review of clinical immunology 2015; 11: 993-1003.
847
Katelaris CH, Carrozzi FM, Burke TV. Allergic rhinoconjunctivitis in elite athletes: optimal management for quality of life and performance. Sports Med 2003; 33: 401-6.
848
Katelaris CH, Carrozzi FM, Burke TV, Byth K. A springtime olympics demands special consideration for allergic athletes. J Allergy Clin Immunol 2000; 106: 260-6.
849
Katelaris CH, Carrozzi FM, Burke TV, Byth K. Effects of intranasal budesonide on symptoms, quality of life, and performance in elite athletes with allergic rhinoconjunctivitis. Clin J Sport Med 2002; 12: 296-300.
850
Dijkstra HP., Robson-Ansley P., The prevalence and current opinion of treatment of allergic rhinitis in elite athletes. Current opinion in allergy and clinical immunology 2011; 11: 103-8.
851
Nieman DC., Pedersen BK., Exercise and immune function. Sports Medicine 1999; 27: 73-80.
852
Steensberg A. et al., Strenuous exercise decreases the percentage of type 1 T cells in the circulation. Journal of applied physiology 2001; 91: 1708-12.
853
Smith LL., Overtraining, excessive exercise, and altered immunity. Sports Medicine 2003; 33: 347-64.
854
Lapucci G, Rasi G, Bonini S, Aloe L, Ambrosini B, Berlutti G, et al. Allergy and infectious diseases in athletes. Journal of Allergy and Clinical Immunology 2003; 111: S142.
855
Nieman DC. et al., Influence of pistachios on performance and exercise-induced inflammation, oxidative stress, immune dysfunction, and metabolite shifts in cyclists: A randomized, crossover trial. PloS one 2014; 9: e113725.
856
Mygind N. and Ronald D., Anatomy, physiology and function of the nasal cavities in health and disease. Advanced drug delivery reviews 1998; 29: 3-12.
857
Dallimore NS. and Eccles R., Changes in human nasal resistance associated with exercise, hyperventilation and rebreathing.Acta oto-laryngologica 1977; 84: 416-421
858
Fisher LH., Michael JD., and Timothy JC., Nasal obstruction, the airway, and the athlete. Clinical reviews in allergy & immunology 2005; 29: 151-158.
859
Helenius I. And Tari H., Allergy and asthma in elite summer sport athletes. Journal of Allergy and Clinical Immunology 2000; 106: 444-52.
860
Bonini S. et al., Rhinitis and asthma in athletes: an ARIA document in collaboration with GA2LEN. Allergy 2006; 61: 681-692.
861
Li J. et al., Chinese response to allergy and asthma in Olympic athletes. Allergy 2008; 63: 962-8.
862
Koskela HO., Cold air-provoked respiratory symptoms: the mechanisms and management. International journal of circumpolar health 2007; 66: 91-100.
863
Alaranta A, Alaranta H, Heliövaara M, Alha P, Palmu P, Helenius I. Allergic rhinitis and pharmacological management in elite athletes. Med Sci Sports Exerc 2005; 37: 707-11.
864
Zwick H, Popp W, Budik G, Wanke T, Rauscher H. Increased sensitization to aeroallergens in competitive swimmers. Lung 1990; 168: 111-5.
865
Bougault V., Turmel J. And Boulet LP., Effect of intense swimming training on rhinitis in high⁰level competitive swimmers. Clinical & Experimental Allergy 2010; 40: 1238-46.
866
Gelardi M, Ventura MT, Fiorella R, Fiorella ML, Russo C, Candreva T, et al. Allergic and non-allergic rhinitis in swimmers: clinical and cytological aspects. Br J Sports Med 2012; 46: 54-8.
867
Carbonnelle S, Francaux M, Doyle I, Dumont X, de Burbure C, Morel G, Michel O, Bernard A. Changes in serum pneumoproteins caused by short-term exposures to nitrogen trichloride in indoor chlorinated swimming pools. Biomarkers 2002; 7: 464-78.
868
Barroso O, Goudreault D, Carbó Banús ML, Ayotte C, Mazzoni I, Boghosian T, et al. Determination of urinary concentrations of pseudoephedrine and cathine after therapeutic administration of pseudoephedrine-containing medications to healthy subjects: implications for doping control analysis of these stimulants banned in sport. Drug Test Anal 2012; 4: 320-9.
869
Weiner JM, Abramson MJ, Puy RM. Intranasal corticosteroids versus oral H1 receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials. BMJ 1998; 317: 1624-9.
870
Robson-Ansley PJ, de Milander L, Collins M, Noakes TD. Acute interleukin-6 administration impairs athletic performance in healthy, trained male runners. Can J Appl Physiol 2004; 29: 411-8.
871
International Consensus Report on the diagnosis and management of rhinitis. International Rhinitis Management Working Group. Allergy 1994; 49: 1-34.
872
Villa-Nova H, Spinola-Castro AM, Garcia FE, Solé D. Prevalence of allergic diseases and/or allergic sensitisation in children and adolescents with type 1 diabetes mellitus. Allergol Immunopathol (Madr) 2015; 43: 157-61.
873
Kowalczyk A, Szalecki M. Allergic diseases in children with type 1 diabetes. Pediatr Endocrinol Diabetes Metab 2013; 19: 100-5.
874
Mizrachi A, Bachar G, Yaniv E, Hadar T, Vinker S. Effect of intranasal steroids on glucose and hemoglobin A1c levels in diabetic patients. Am J Rhinol Allergy 2012; 26: 395-7. [
875
Akkaş İ, Toptaş O, Özan F. Ağız kuruluğu. Acta Odontol Turc 2014; 31: 54-60.
876
Degirmenci PB, Kirmaz C, Oz D, Bilgir F, Ozmen B, Degirmenci M, Colak H, Yılmaz H, Ozyurt B. Allergic rhinitis and its relationship with autoimmune thyroid diseases. Am J Rhinol Allergy 2015; 29: 257-61.
877
Hidaka Y, Amino N, Iwatani Y, Itoh E, Matsunaga M, Tamaki H.Recurrence of thyrotoxicosis after attack of allergic rhinitis in patients with Graves’ disease. J Clin Endocrinol Metab 1993; 77: 1667-70.
878
Gamzatova AA, Gadzhimirzaev GA, Abusuev SA, Gamzatova EG. Treatment of allergic rhinitis associated with hypothyroidism. Vestn Otorinolaringol 2006; 6: 34-7.
879
Chaudhry HS, Bhimji SS. Cushing Syndrome. Stat Pearls . Treasure Island (FL): StatPearls Publishing; 2017- 2017 Dec 18.
880
Raveendran AV. Inhalational Steroids and Iatrogenic Cushing’s Syndrome. Open Respir Med J 2014; 8: 74-84.
881
Siracusa A, Desrosiers M, Marabini A. Epidemiology of occupational rhinitis: prevalence, aetiology and determinants. Clin Exp Allergy 2000; 30: 1519-34.
882
Mazurek J M, Paul K. Henneberger Lifetime allergic rhinitis prevalence among US primary farm operators: findings from the 2011 Farm and Ranch Safety survey. Int Arch Occup Environ Health 2017; 90: 507-15.
883
Jonaid BS, Rooyackers J, Stigter E, Portengen L, Krop E, Heederik D. Predicting occupational asthma and rhinitis in bakery workers referred for clinical evaluation. Occup Environ Med 2017; 74: 564-72.
884
Mazurek JM, Weissman DN. Occupational Respiratory Allergic Diseases in Healthcare Workers. Curr Allergy Asthma Rep 2016; 16: 77.
885
Hindmarch I, Shamsi Z. Antihistamines: models to assess sedative properties, assessment of sedation, safety and other side-effects. Clin Exp Allergy 1999; 29: 133-42.
886
Dobashi K, Akiyama K, Usami A, Yokozeki H, Ikezawa Z, Tsurikisawa N, et al. Japanese Guideline for occupational allergic diseases 2017. Allergol Int 2017; 66: 265-80.
887
Cusack BJ. Pharmacokinetics in older persons. Am J Geriatr Pharmacother 2004; 2: 274-302.
888
King MJ, Tamulis T, Lockey RF. Prick puncture skin tests and serum specific IgE as predictors of nasal challenge response to Dermatophagoides pteronyssinus in older adults. Ann Allergy Asthma Immunol 2008; 101: 12-7.
889
Moghadam-Kia S, Werth VP. Prevention and treatment of systemic glucocorticoid side effects. Int J Dermatol 2010; 49: 239-48.
890
Hernandez-Trujillo V. Antihistamines treatment for allergic rhinitis: different routes, different mechanisms? Allergy Asthma Proc 2009; 30: 584-8.
891
Townley RG. Antiallergic properties of the second-generation H1 antihistamines during the early and late reactions to antigen. J Allergy Clin Immunol 1992; 90: 720-5.
892
Carter NJ. Bilastine. Drugs 2012; 72:1257-69.
893
Simons FER. The antiallergic effects of antihistamines (H1-receptor antagonists). J Allergy Clin Immunol 1992; 90: 705-15.
894
Jones AW. Perspectives in drug development and clinical pharmacology: the discovery of histamine H1 and H2 antagonists. Clin Pharmacol Drug Dev 2016; 5: 5-12.
895
Wang XY, Lim-Jurado M, Prepageran N, Tantilipikorn P, Wang DY. Treatment of allergic rhinitis and urticaria: a review of the newest antihistamine drug bilastine. Ther Clin Risk Manag 2016; 12: 585-97.
896
Chhabra N, Houser SM. Surgery for allergic rhinitis. Int Forum Allergy Rhinol 2014; 4: S79-83.
897
Millas I, Liquidato BM, Dolci JE, Fregnani JH, Macéa JR. Histological analysis of the distribution pattern of glandular tissue in normal inferior nasal turbinates. Braz J Otorhinolaryngol 2009 ; 75: 507-10.
898
Schmelzer B, Katz S, Vidts G. Long-term efficacy of our surgical approach to turbinate hypertrophy. Am J Rhinol 1999; 13: 357-61.
899
Mabry RL. Surgery of the inferior turbinates: how much and when? Otolaryngol Head Neck Surg 1984; 92: 571-6.
900
Lippert BM, Werner JA. CO2 laser surgery of hypertrophied inferior turbinates. Rhinology 1997; 35: 33-6.
901
Hol MK, Huizing EH. Treatment of inferior turbinate pathology: a review and critical evaluation of the different techniques. Rhinology 2000; 38: 157-66.
902
K Kim YH, Kim BJ, Bang KH, Hwang Y, Jang TY. Septoplasty improves life quality related to allergy in patients with septal deviation and allergic rhinitis. Otolaryngol Head Neck Surg 2011; 145: 910-4.
903
Fettallah UC., Alt Konka Hipertrofilerinde Radyofrekans Termal Ablasyon Sonuçlarının Manyetik Rezonans Görüntülemesi İle Değerlendirilmesi, 2005, İstanbul, Uzmanlık tezi.
904
Hamerschmidt R, Hamerschmidt R, Moreira AT, Tenório SB, Timi JR. Comparison of turbinoplasty surgery efficacy in patients with and without allergic rhinitis. Braz J Otorhinolaryngol 2016; 82: 131-9.
905
Mabry RL. Visual loss after intranasal corticosteroid injection. Incidence, causes, and prevention. Arch Otolaryngol 1981; 107: 484-6.
906
Houser SM. Surgical treatment for empty nose syndrome. Arch Otolaryngol Head Neck Surg 2007; 133: 858-63.
907
Passàli D, Lauriello M, Anselmi M, Bellussi L. Treatment of hypertrophy of the inferior turbinate: long-term results in 382 patients randomly assigned to therapy. Ann Otol Rhinol Laryngol 1999; 108: 569-75.
908
O’Flynn PE, Milford CA, Mackay IS. Multiple submucosal out-fractures of interior turbinates. J Laryngol Otol 1990; 104: 239-40.
909
Lin HC, Lin PW, Su CY, Chang HW. Radiofrequency for the treatment of allergic rhinitis refractory to medical therapy. Laryngoscope 2003; 113: 673-8.
910
Mori S, Fujieda S, Yamada T, Kimura Y, Takahashi N, Saito H. Long-term effect of submucous turbinectomy in patients with perennial allergic rhinitis. Laryngoscope 2002; 112: 865-9.
911
Chen YL, Tan CT, Huang HM. Long-term efficacy of microdebrider-assisted inferior turbinoplasty with lateralization for hypertrophic inferior turbinates in patients with perennial allergic rhinitis. Laryngoscope 2008; 118: 1270-4.
912
El Henawi Del D, Ahmed MR, Madian YT. Comparison between power-assisted turbinoplasty and submucosal resection in the treatment of inferior turbinate hypertrophy. ORL J Otorhinolaryngol Relat Spec 2011; 73: 151-5.
913
Elwany S, Abel Salaam S. Laser surgery for allergic rhinitis: the effect on seromucinous glands. Otolaryngol Head Neck Surg 1999; 120: 742-4.
914
Caffier PP, Scherer H, Neumann K, Lück S, Enzmann H, Haisch A. Diode laser treatment in therapy-resistant allergic rhinitis: impact on nasal obstruction and associated symptoms. Lasers Med Sci 2011; 26: 57-67.
915
Lin HC, Lin PW, Friedman M, Chang HW, Su YY, Chen YJ, Pulver TM. Long-term results of radiofrequency turbinoplasty for allergic rhinitis refractory to medical therapy. Arch Otolaryngol Head Neck Surg 2010; 136: 892-5.
916
Aksoy F., Alt konka hipertrofisinde radyofrekans uygulaması, Göztepe Tıp Dergisi 2010; 25: 29-33.
917
Siméon R, Soufflet B, Souchal Delacour I. Coblation turbinate reduction in childhood allergic rhinitis. Eur Ann Otorhinolaryngol Head Neck Dis 2010; 127: 77-82.
918
Jalowayski AA, Yuh YS, Koziol JA, Davidson TM. Surgery for nasal obstruction--evaluation by rhinomanometry. Laryngoscope 1983; 93: 341-5.
919
Karatzanis AD, Fragiadakis G, Moshandrea J, Zenk J, Iro H, Velegrakis GA. Septoplasty outcome in patients with and without allergic rhinitis. Rhinology 2009; 47: 444-9.
920
Stoksted P, Gutierrez C. The nasal passage following rhinoplastic surgery. J Laryngol Otol 1983; 97: 49-54.
921
Pedersen Fjermedal O, Saunte C, Pedersen S. Septoplasty and/or submucous resection? 5 years nasal septum operations. J Laryngol Otol 1988; 102: 796-8.
922
Cervin A, Andersson M. Intranasal steroids and septum perforation--an overlooked complication? A description of the course of events and a discussion of the causes. Rhinology 1998; 36: 128-32.
923
Topal O, Celik SB, Erbek S, Erbek SS. Risk of nasal septal perforation following septoplasty in patients with allergic rhinitis. Eur Arch Otorhinolaryngol 2011; 268: 231-3.
924
Marshak T, Yun WK, Hazout C, Sacks R, Harvey RJ. A systematic review of the evidence base for vidian neurectomy in managing rhinitis. J Laryngol Otol 2016; 130: S7-S28.
925
Golding-Wood PH. Observations on petrosal and vidian neurectomy in chronic vasomotor rhinitis. J Laryngol Otol 1961; 75: 232-47.
926
Lee JC, Lin YS. Endoscopic vidian neurectomy: update on techniques and evidence. Curr Opin Otolaryngol Head Neck Surg 2012; 20: 66-72.
927
Kamel R, Zaher S. Endoscopic transnasal vidian neurectomy. Laryngoscope 1991; 101: 316-319.
928
El Shazly M. Endoscopic surgery of the vidian nerve: preliminary report. Ann Otol Rhinol Laryngol 1991; 100: 536-9.
929
El-Guindy A. Endoscopic transseptal vidian neurectomy. Arch Otolaryngol Head Neck Surg 1994; 120: 1347-1351.
930
Robinson SR, Wormald PJ. Endoscopic vidian neurectomy. Am J Rhinol 2006; 20: 197-202.
931
Lee JC, Hsu CH, Kao CH, Lin YS. Endoscopic intrasphenoidal vidian neurectomy: how we do it. Clin Otolaryngol 2009; 34: 568-571.
932
Liu SC, Wang HW, Su WF. Endoscopic vidian neurectomy: the value of preoperative computed tomographic guidance. Arch Otolaryngol Head Neck Surg 2010; 136: 595-602.
933
Jang TY, Kim YH, Shin SH. Long-term effectiveness and safety of endoscopic vidian neurectomy for the treatment of intractable rhinitis. Clin Exp Otorhinolarygol 2010; 4: 212-216.
934
Melzack R, Stillwell DM, Fox EJ. Trigger points and acupuncture points for pain: correlations and implications. Pain 1977; 3: 3-23.
935
Asher GN, Jonas DE, Coeytaux RR, Reilly AC, Loh YL, Motsinger- Reif AA, Winham SJ. Auriculotherapy for pain management: a systematic review and meta-analysis of randomized controlled trials. J Altern Complement Med 2010; 16: 1097-108.
936
Molsberger A. Acupuncture in orthopedics. Orthopade 2012; 41: 100-5.
937
Stör W, Irnich D. Acupuncture: basics, practice, and evidence. Schmerz 2009; 23: 405-17.
938
Kim SK, Bae H. Acupuncture and immune modulation. Auton Neurosci 2010; 157: 38-41.
939
Petti F, Bangrazi A, Liguori A, Reale G, Ippoliti F. Effects of acupuncture on immune response related to opioid-like peptides. J Tradit Chin Med 1998; 18: 55-63.
940
Arranz L, Guayerbas N, Siboni L, Fuente M de la. Effect of acupuncture treatment on the immune function impairment found in anxious women. Am J Chin Med 2007; 35: 35-51.
941
Kim CK, Choi GS, Oh SD, Han JB, Kim SK, Ahn HJ, Bae H, Min BI. Electroacupuncture up-regulates natural killer cell activity: identification of genes altering their expressions in electroacupuncture induced up-regulation of natural killer cell activity. J Neuroimmunol 2005; 168: 144-53.
942
Lau BH, Wong DS, Slater JM. Effect of acupuncture on allergic rhinitis: clinical and laboratory evaluations. Am J Chin Med 1975; 3: 263-70.
943
Carneiro ER, Xavier RA, De Castro MA, Do Nascimento CM, Silveira VL. Electroacupuncture promotes a decrease in inflammatory response associated with Th1/Th2 cytokines, nitric oxide and leukotriene B4 modulation in experimental asthma. Cytokine 2010; 50: 335-40.
944
Jeong HJ, Kim BS, Oh JG, Kim KS, Kim HM. Regulatory effect of cytokine production in asthma patients by SOOJI CHIM (Koryo Hand Acupuncture Therapy). Immunopharmacol Immunotoxicol 2002; 24: 265-74.
945
Joos, S, Schott C, Zou H, Daniel V, Martin E. Immunomodulatory effects of acupuncture in the treatment of allergic asthma. J Altern Complement 2000; 6: 519-25.
946
Petti FB, Liguori A, Ippoliti F. Study on cytokines IL-2, IL-6, IL-10 in patients of chronic allergic rhinitis treated with acupuncture. J Tradit Chin Med 2002; 22: 104-11.
947
Rao YQ, Han NY. Therapeutic effect of acupuncture on allergic rhinitis and its eff ects on immunologic function. Zhongguo Zhen Jiu 2006; 26: 557-60
948
Christensen PA, Lauren LC, Taudorf E, Sørensen SC, Weeke B. Acupuncture and bronchial asthma. Allergy 1984; 39: 379-85.
949
Jianli CJ. The effect of acupuncture on serum IgE level in patients with chronic urticaria. Tradit Chin Med 2006; 26: 189-90.
950
Brinkhaus B, Witt CM, Jena S, Liecker B, Wegscheider K, Willich SN. Acupuncture in patients with allergic rhinitis: a pragmatic randomized trial. Ann Allergy Asthma Immunol 2008; 101: 535-43.
951
Ng DK, Chow PY, Ming Ng DK, Chow PY, Ming SP, Hong SH, et al. A double-blind, randomized, placebo-controlled trial of acupuncture for the treatment of childhood persistent allergic rhinitis. Pediatrics 2004; 114: 1242-7.
952
Williamson L, Yudkin P, Livingstone R, Prasad K, Fuller A, Lawrence M. Hay fever treatment in general practice: a randomised controlled trial comparing stan-dardised Western acupuncture with sham acupuncture. Acupunct Med 1996; 14: 6-10.
953
Pfab F, Kirchner MT, Huss-Marp J, Schuster T, Schalock PC, Fuqin J, et al. Acupuncture compared with oral antihistamine for type I hypersensitivity itch and skin response in adults with atopic dermatitis: a patient- and examiner-blinded, randomized, placebo-controlled, crossover trial. Allergy 2012; 67: 566-73. d
954
Lee MS, Pittler MH, Shin BC, Kim JI, Ernst E. Acupuncture for allergic rhinitis: a systematic review. Ann Allergy Asthma Immunol 2009; 102: 269-79.
955
Roberts J. A systematic review of the clinical effectiveness of acupuncture for allergic rhinitis. BMC Complement Altern Med 2008; 8: 13.
956
Brinkhaus B, Ortiz M, Witt CM, Roll S, Linde K, Pfab F, et al. Acupuncture in patients with seasonal allergic rhinitis: a randomized trial. Ann Intern Med 2013; 158: 225-34.
957
Kim JI, Lee MS, Jung SY, Choi JY, Lee S, Ko JM, et al. Acupuncture for persistent allergic rhinitis: a multi-centre, randomised, controlled trial protocol. Trials 2009; 10: 54.
958
Kim JI, Choi JY, Lee MS, Kim TH, Kim AR, Jung SY, et al. Acupuncture for improving chronic rhinosinusitis complicated with persistent allergic rhinitis. A prospective observational study. Forsch Komplementmed 2010; 17: 333-5.
959
Michael D. Seidman, MD, Richard K. Gurgel, MD, Sandra Y. Lin, MD et al. Clinical Practice Guideline: Allergic Rhinitis Executive Summary Otolaryngology Head and Neck Surgery 2015;152:197-206.
960
Sanders ME, Guarner F, Guerrant R, Holt PR, Quigley EM, Sartor RB et al. An update on the use and investigation of probiotics in health and disease. Gut 2013; 62: 787-96.
961
Zuccotti G, Meneghin F, Aceti A, Barone G, Callegari ML, Di Mauro A. Probiotics for prevention of atopic diseases in infants: systematic review and meta-analysis. Allergy. 2015; 70: 1356-71.
962
Sepp E, Julge K, Mikelsaar M, Björkstén B. Intestinal microbiota and immunoglobulin E responses in 5-year-old Estonian children. Clin Exp Allergy 2005 ; 35: 1141-6.
963
Björkstén B, Sepp E, Julge K, Voor T, Mikelsaar M. Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol 2001; 108: 516-20.
964
Penders J, Stobberingh EE, Thijs C, Adams H, Vink C, van Ree R et al. Molecular fingerprinting of the intestinal microbiota of infants in whom atopic eczema was or was not developing. Clin Exp Allergy 2006; 36: 1602-8.
965
Masuda S, Yamaguchi H, Kurokawa T, Shirakami T, Tsuji RF, Nishimura I. Immunomodulatory effect of halophilic lactic acid bacterium Tetragenococcus halophilus Th221 from soy sauce moromi grown in high-salt medium. Int J Food Microbiol 2008; 121: 245-52.
966
Torii A, Torii S, Fujiwara S, Tanaka H, Inagaki N, Nagai H. Lactobacillus Acidophilus strain L-92 regulates the production of Th1 cytokine as well as Th2 cytokines. Allergol Int 2007; 56: 293-301.
967
Batchelor JM, Grindlay DJ, Williams HC. What’s new in atopic eczema? An analysis of systematic reviews published in 2008 and 2009. Clin Exp Dermatol 2010; 35: 823-7.
968
Zajac AE, Adams AS, Turner JH. A systematic review and meta-analysis of probiotics for the treatment of allergic rhinitis. Int Forum Allergy Rhinol 2015; 5: 524-32.
969
Güvenç IA, Muluk NB, Mutlu FŞ, Eşki E, Altıntoprak N, Oktemer T,et al. Do probiotics have a role in the treatment of allergic rhinitis? A comprehensive systematic review and meta-analysis. Am J Rhinol Allergy 2016; 30: 157-75.
970
Miraglia Del Giudice M, Indolfi C, Capasso M, Maiello N, Decimo F, Ciprandi G et al. Bifidobacterium mixture (B longum BB536, B infantis M-63, B breve M-16V) treatment in children with seasonal allergic rhinitis and intermittent asthma. Ital J Pediatr 2017; 43: 25.
971
Dennis-Wall JC, Culpepper T, Nieves C Jr, Rowe CC, Burns AM, Rusch CTü et al. Probiotics (Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2) improve rhinoconjunctivitis-specific quality of life in individuals with seasonal allergies: a double-blind, placebo-controlled, randomized trial. Am J Clin Nutr 2017; 105: 758-67.
972
Tang ML, Ponsonby AL, Orsini F, Tey D, Robinson M, Su EL, et al. Administration of a probiotic with peanut oral immunotherapy: A randomized trial. J Allergy Clin Immunol 2015; 135: 737-44.e8.
973
Jerzynska J, Stelmach W, Balcerak J, Woicka-Kolejwa K, Rychlik B, Blauz A, et al. Effect of Lactobacillus rhamnosus GG and vitamin D supplementation on the immunologic effectiveness of grass-specific sublingual immunotherapy in children with allergy. Allergy Asthma Proc 2016; 37: 324-34.
974
Simpson MR, Dotterud CK, Storrø O, Johnsen R, Øien T. Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial. BMC Dermatol 2015; 15: 13.
975
Costa DJ, Marteau P, Amouyal M, Poulsen LK, Hamelmann E, Cazaubiel M, et al. Efficacy and safety of the probiotic Lactobacillus paracasei LP-33 in allergic rhinitis: a double-blind, randomized, placebo-controlled trial (GA2LEN Study). Eur J Clin Nutr 2014; 68: 602-7.
976
Lin WY, Fu LS, Lin HK, Shen CY, Chen YJ. Evaluation of the effect of Lactobacillus paracasei (HF.A00232) in children (6-13 years old) with perennial allergic rhinitis: a 12-week, double-blind, randomized, placebo-controlled study. Pediatr Neonatol 2014; 55: 181-8.
977
Ivory K, Wilson AM, Sankaran P, Westwood M, McCarville J, Brockwell C, et al. Oral delivery of a probiotic induced changes at the nasal mucosa of seasonal allergic rhinitis subjects after local allergen challenge: a randomised clinical trial. PLoS One 2013; 8: e78650.
978
Dölle S, Berg J, Rasche C, Worm M. Tolerability and clinical outcome of coseasonal treatment with Escherichia coli strain Nissle 1917 in grass pollen-allergic subjects. Int Arch Allergy Immunol 2014; 163: 29-35.
979
Cho HK, Jeong YM, Lee HS, Lee YJ, Hwang SH. Efficacy of endonasal phototherapy for relieving the symptoms of allergic rhinitis: Meta-analysis. Am J Rhinol Allergy 2015; 29: 283-91.
980
Bella Z, Kiricsi Á, Viharosné ÉD, Dallos A, Perényi Á, Kiss M et.al. Rhinophototherapy in persistent allergic rhinitis. Eur Arch Otorhinolaryngol 2017; 274: 1543-50.
981
Alyasin S, Nabavizadeh SH, Houshmand H, Esmaeilzadeh H, Jelodar S, Amin R. Short Time Efficiency of Rhinophototherapy in Management of Patients with Allergic Rhinitis Resistant to Medical TherapyIran J Allergy Asthma Immunol 2016; 15: 317-27.
982
Tatar EÇ, Korkmaz H, Sürenoğlu UA, Saylam G, Ozdek A, Clin Exp Otorhinolaryngol 2013; 6: 73-7.
983
Weichenthal M, Schwarz T. Phototherapy: how does UV work? Photodermatol Photoimmunol Photomed 2005; 21: 260-6.
984
Yurttaş V, Şereflican M, Erkoçoğlu M, Terzi EH, Kükner A, Oral M. Histopathological effects of intranasal phototherapy and nasal corticosteroids in allergic rhinitis in a rabbit model. J Photochem Photobiol B 2015; 149: 289-91.
985
Kitamura Y, Mizuguchi H, Okamoto K, Kitayama M, Fujii T, Fujioka A et.al. Irradiation with narrowband-ultraviolet B suppresses phorbol ester-induced up-regulation of H1 receptor mRNA in HeLa cells. Acta Otolaryngol 2016; 136: 409-13.
986
Yıldırım YS, Apuhan T, Koçoğlu E Effects of intranasal phototherapy on nasal microbial flora in patients with allergic rhinitis. Iran J Allergy Asthma Immunol 2013; 12: 281-6.
987
Demirbaş D, Aksoy E, Polat S, Serin G, Unal OF, Tanyeri H. Endonasal phototherapy in the treatment of allergic rhinitis. Kulak Burun Bogaz Ihtis Derg 2011;21: 198-203.
988
Yaz, A, Cingi C, Gürbüz M, Bal C. The long-term results of the impact of rhinophototherapy on quality of life in cases with allergic rhinitis. J Med Updates 2012; 2: 63-9.
989
Akdağ M, Bakır S, Agüloğlu B, Demir H, Topçu İ. Tedaviye dirençli alerjik rinitli olgularda intranazal fototerapinin erken dönem sonuçları. Turkish J Rhinology 2014; 3: 2.
990
Wen, W.-D., Yuan, F., Wang, J.-L., Hou, Y.-P. Botulinum toxin therapy in the ovalbumin-sensitized rat. Neuroimmunomodulation 2006; 14: 78-83.
991
Zhu, Z., Stone, H.F., Thach, T.Q., Garcia, L., Ruegg, C.L. A novel botulinum neurotoxin topical gel: Treatment of allergic rhinitis in rats and comparative safety profile. Am. J. Rhinol Allergy 2012 ; 26: 450-4.
992
Ozcan C, Ismi O .Botulinum Toxin for Rhinitis. Curr Allergy Asthma Rep 2016;16: 58.
993
Zhang EZ, an S, Loh I. Botolinum toxin in rhinitis: Literature review and posterior nasal injection in allergic rhinitis. Laryngoscope 2017; 127: 2447-54.
994
Güneş MS, Külahlı I, Kökoğlu K, Vural A, Avcı D, Güleç S, et al. Evaluation of the effect of intranasal infiltrated botulinum toxin-A on a model of allergic rhinitis in rabbits: An Experimental Study. Int J Pediatr Otorhinolaryngol 2016; 83: 51-6.
